{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:54:31Z","timestamp":1790747671434,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pancreatitis in patients with hematologic malignancies, particularly lymphoma, is a challenging complication with heterogeneous etiologies. Large studies with systematic etiological classification and prognostic models are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study (2020\u20132025) included patients with hematologic malignancies who developed acute pancreatitis. Etiologies were adjudicated using predefined criteria. A nomogram-based prediction model was developed with internal bootstrap validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1,705 patients, 31 (1.82%) developed pancreatitis: 19 lymphoma (61.3%), 9 leukemia (29.0%), and 3 plasma cell disorders (9.7%). In the lymphoma cohort (median age 59 years, 57.9% male), diffuse large B-cell lymphoma (47.4%) and peripheral T-cell lymphoma (PTCL) (21.1%) were most common. Etiology distribution: treatment-related (36.8%), direct pancreatic infiltration (31.6%), conventional (15.8%), multifactorial (10.5%), and infection-related (5.3%). Endoscopic ultrasound (EUS)-guided tissue acquisition had 83.3% diagnostic sensitivity for direct infiltration; positron emission tomography\/computed tomography (PET-CT) showed a \u201ctetrad sign\u201d in 5\/6 cases. Severe pancreatitis occurred in 21.1% of lymphoma-associated pancreatitis. The nomogram (incorporating time to pancreatitis \u226430 days, recent L-asparaginase (LAsp)\/immune checkpoint inhibitors (ICIs) exposure, and absence of pancreatic mass) discriminated treatment-related from non-treatment-related etiologies with AUC 0.84 (95% CI 0.71\u20130.96). PTCL subtype (HR 3.12, 95% CI 1.28\u20137.61, p=0.012), multifactorial etiology (HR 2.56, 95% CI 1.02\u20136.42, p=0.045), and age \u226565 years (HR 2.01, 95% CI 0.95\u20134.25, p=0.07) predicted 1-year mortality (C-index 0.79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Lymphoma-associated pancreatitis is rare (1.8% of hematologic malignancies). Treatment-related causes slightly outnumber direct infiltration. EUS-guided tissue acquisition and PET-CT are valuable for differential diagnosis. The nomogram may assist etiological classification and risk stratification, but prospective validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1853848","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:55:14Z","timestamp":1790744114000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphoma-associated pancreatitis: a multicenter retrospective cohort study with a prediction model"],"prefix":"10.3389","volume":"16","author":[{"given":"Juju","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Spleen and Stomach Disease, Yulin Traditional Chinese Medicine Hospital","place":["Yulin, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Health Science Center, Yangtze University","place":["Jingzhou, Hubei, 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Xi\u2019an Jiao Tong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Jiao Tong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Jiao Tong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2022.0223","article-title":"Clinical practice guideline\u2014acute and chronic pancreatitis","volume":"119","author":"Beyer","year":"2022","journal-title":"Dtsch Arztebl 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