{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:04:42Z","timestamp":1780031082535,"version":"3.53.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>We report a rare case of a collision tumor in a patient concurrently diagnosed with lymphoepithelioma-like carcinoma (LELC) and T-cell non-Hodgkin lymphoma (NHL-T). The patient was a 61-year-old male presenting with a one-week history of low back pain. Positron emission tomography\u2013computed tomography (PET-CT) revealed hypermetabolic masses in the anterior mediastinum, adjacent to right cardiophrenic angle, in the retroperitoneum, and adjacent to the left iliac vessels in the pelvis. The puncture biopsy of the mass adjacent to the cardiophrenic angle suggested LELC coexisting with NHL-T. The patient was treated with a combination regimen of a PD-1 inhibitor and platinum-based chemotherapy, but disease progression was observed. Subsequent biopsy of the pelvic mass confirmed the presence of NHL-T. The treatment regimen was then modified to include a PD-1 inhibitor, bortezomib, and ICE (ifosfamide, carboplatin, etoposide) chemotherapy. After two cycles, the response was assessed as partial remission. The patient remains on ongoing therapy. This case highlights diagnostic challenges and provides insights into the management of such rare collision tumors.<\/jats:p>","DOI":"10.3389\/fonc.2026.1855118","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:45:28Z","timestamp":1780029928000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare collision tumor of lymphoepithelioma-like carcinoma and t-cell lymphoma: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Mengping","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Hematology, Lishui Municipal Central Hospital","place":["Lishui, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lishui Municipal Central Hospital","place":["Lishui, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2021.045","article-title":"Epstein-Barr virus-associated mixed lymphoepithelioma-like carcinoma and adenocarcinoma of the gall bladder: an unusual entity","volume":"78","author":"Jain","year":"2021","journal-title":"Korean J Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11899-024-00727-w","article-title":"Update on T-cell lymphoma epidemiology","volume":"19","author":"Chen","year":"2024","journal-title":"Curr Hematol Malig Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1792_19","article-title":"Cutaneous T-cell lymphoma","volume":"152","author":"Arora","year":"2020","journal-title":"Indian J Med Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2024.05.012","article-title":"Cutaneous T-cell lymphoma","volume":"38","author":"Weiner","year":"2024","journal-title":"Hematol Oncol Clin North Am"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14236","article-title":"Collision tumors: a review of their types, pathogenesis, and diagnostic challenges","volume":"33","author":"Bulte","year":"2020","journal-title":"Dermatol Ther"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11855","article-title":"Collision of lymphoepithelioma-like carcinoma with diffuse large B-cell lymphoma of the stomach: a case report","volume":"37","author":"Liu","year":"2017","journal-title":"Anticancer Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2023.1184322","article-title":"Appendiceal collision tumors: case reports, management and literature review","volume":"10","author":"Viel","year":"2023","journal-title":"Front Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0529-5807.2020.01.016","article-title":"Clinicopathological features of lymphoepithelioma-like carcinoma","volume":"49","author":"Zheng","year":"2020","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1202117","article-title":"Pathogenesis and therapeutic implications of EBV-associated epithelial cancers","volume":"13","author":"Low","year":"2023","journal-title":"Front Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-020-1344-3","article-title":"Primary pulmonary lymphoepithelioma-like carcinoma","volume":"37","author":"Fan","year":"2020","journal-title":"Med Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2024.10.002","article-title":"Lymphoepithelioma-like carcinoma presents as a bronchial nodule","volume":"61","author":"Luo","year":"2025","journal-title":"Arch Bronconeumol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v16.i5.1436","article-title":"Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: a case report","volume":"16","author":"Chen","year":"2024","journal-title":"World J Gastrointest Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1150715","article-title":"Challenges in nodal peripheral T-cell lymphomas: from biological advances to clinical applicability","volume":"13","author":"Zain","year":"2023","journal-title":"Front Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2021.100126","article-title":"Comprehensive analysis of peripheral T-cell and natural killer\/T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia","volume":"10","author":"Yoon","year":"2021","journal-title":"Lancet Reg Health West Pac"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15153","article-title":"Mixed HPV-related neuroendocrine carcinoma and HPV-related squamous cell carcinoma of the base of tongue in a patient with incidental identification of synchronous metastatic papillary thyroid carcinoma","volume":"41","author":"Cao","year":"2021","journal-title":"Anticancer Res"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i26.6289","article-title":"Collision tumor of primary Malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology: a case report and literature review","volume":"11","author":"Jiang","year":"2023","journal-title":"World J Clin cases"},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.36255\/exon-publications.lymphoma.2021.setd2-lymphoid-malignancy","article-title":"Histone methyltransferase SETD2 in lymphoid Malignancy","volume-title":"Lymphoma","author":"Li","year":"2021"},{"key":"B18","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1182\/blood.2022018200","article-title":"Hepatosplenic T-cell lymphoma with STAT5B and SETD2 mutations recurring as cells with NK-cell immunophenotype","volume":"141","author":"Khodadoust","year":"2023","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02777-2","article-title":"Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma","volume":"40","author":"Vallois","year":"2026","journal-title":"Leukemia"},{"key":"B20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.22551\/2021.33.0804.10191","article-title":"Collision tumors of the thyroid. A special clinical and pathological entity","volume":"8","author":"Bojoga","year":"2021","journal-title":"Arch Clin cases"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.21614\/chirurgia.120.eC.3082","article-title":"Collision tumor consisting of mantle cell lymphoma and mucinous adenocarcinoma in ascending colon: case report","volume":"120","author":"Perovic","year":"2025","journal-title":"Chirurgia (Bucur)"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.110808","article-title":"Collision-type adenosquamous carcinoma of the colon with signet-ring adenocarcinoma: a rare case report","volume":"127","author":"Chohan","year":"2025","journal-title":"Int J Surg Case Rep"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S241337","article-title":"Pulmonary lymphoepithelioma-like carcinoma: a mini-review","volume":"13","author":"Hu","year":"2020","journal-title":"Onco Targets Ther"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1001414","article-title":"Anti-PD-1 antibodies, a novel treatment option for advanced chemoresistant pulmonary lymphoepithelioma carcinoma","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112152-20230714-00013","article-title":"Efficacy analysis of PD-1\/PD-L1 inhibitors in the treatment of advanced primary pulmonary lymphoepithelioma-like carcinoma: 6 case reports and literature review","volume":"46","author":"Zhang","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.32471\/exp-oncology.2312-8852.vol-43-no-4.17151","article-title":"Ukrainian prospective study in patients with T-cell non-Hodgkin lymphomas","volume":"43","author":"Kriachok","year":"2021","journal-title":"Exp Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1055\/a-2427-2066","article-title":"Neoadjuvant immunotherapy and de-escalation of surgery in locally advanced breast implant-associated anaplastic large cell lymphoma","volume":"52","author":"Salgarello","year":"2024","journal-title":"Arch Plast Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1225610","article-title":"Novel anti-CD30\/CD3 bispecific antibodies activate human T cells and mediate potent anti-tumor activity","volume":"14","author":"Faber","year":"2023","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9350272","article-title":"Current clinical applications and future perspectives of immune checkpoint inhibitors in non-Hodgkin lymphoma","volume":"2020","author":"Apostolidis","year":"2020","journal-title":"J Immunol Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2024.479","article-title":"Assessing the efficacy of Bortezomib and Dexamethasone for induction and maintenance therapy in relapsed\/refractory cutaneous T-cell lymphoma: a phase II CISL1701\/BIC study","volume":"57","author":"Choi","year":"2025","journal-title":"Cancer Res Treat"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02678","article-title":"Children's Oncology Group Trial AALL1231: a phase III clinical trial testing Bortezomib in newly diagnosed T-cell acute lymphoblastic leukemia and lymphoma","volume":"40","author":"Teachey","year":"2022","journal-title":"J Clin Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1855118\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:45:44Z","timestamp":1780029944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1855118\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":31,"alternative-id":["10.3389\/fonc.2026.1855118"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1855118","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"1855118"}}