{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:39Z","timestamp":1782103779285,"version":"3.54.5"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Myeloid\/lymphoid neoplasms with\n                    <jats:italic>PDGFRB<\/jats:italic>\n                    rearrangements are rare hematologic malignancies usually associated with eosinophilia and sensitivity to tyrosine kinase inhibitors, whereas atypical presentations remain poorly defined. We report a 60-year-old man with persistent leukocytosis and thrombocytopenia detected during a routine health examination. Bone marrow examination revealed marked granulocytic proliferation without increased blasts, and peripheral blood showed predominant neutrophilia with only mild eosinophilia. Cytogenetic analysis identified a t(5;14) translocation. RNA sequencing detected an in-frame\n                    <jats:italic>CCDC88C exon 12::PDGFRB<\/jats:italic>\n                    exon 11 fusion, and targeted sequencing additionally identified an\n                    <jats:italic>ATM<\/jats:italic>\n                    frameshift mutation. Treatment with low-dose imatinib (200 mg daily) led to rapid normalization of leukocyte counts within one week and sustained hematologic remission during follow-up. This case broadens the clinicopathologic spectrum of\n                    <jats:italic>CCDC88C::PDGFRB<\/jats:italic>\n                    -rearranged neoplasms and highlights the value of RNA sequencing in identifying actionable kinase fusions in atypical myeloproliferative presentations.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1855322","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:32:03Z","timestamp":1782102723000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["CCDC88C::PDGFRB-rearranged myeloid neoplasm with predominant neutrophilia and rapid response to imatinib: a molecularly defined case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Yafei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Hematology, the Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genwang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, the Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhe","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology, the Second Affiliated Hospital of Fujian Medical University","place":["Quanzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022417","article-title":"How I diagnose and treat myeloid\/lymphoid neoplasms with tyrosine kinase gene fusions","volume":"145","author":"Reiter","year":"2025","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa056","article-title":"Contemporary classification and diagnostic evaluation of hypereosinophilia","volume":"154","author":"Mattis","year":"2020","journal-title":"Am J Clin 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analysis of 7 cases of childhood acute lymphoblastic leukemia with PDGFRB rearrangement","volume":"28","author":"Tao","year":"2026","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27020656","article-title":"Targeted therapy for a rare PDGFRB-rearranged myeloproliferative neoplasm: A case report","volume":"27","author":"Barbato","year":"2026","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22153","article-title":"Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid\/lymphoid neoplasms","volume":"53","author":"Gosenca","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3067-x","article-title":"Imatinib in myeloid\/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast 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fusion","volume":"113","author":"Oya","year":"2021","journal-title":"Int J Hematol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1855322\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:32:13Z","timestamp":1782102733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1855322\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":12,"alternative-id":["10.3389\/fonc.2026.1855322"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1855322","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"article-number":"1855322"}}