{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:19:00Z","timestamp":1787548740230,"version":"build-2736575974"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Familial adenomatous polyposis is known to progress into colorectal cancer, and extra-intestinal malignancies have also been reported. However, testicular sex cord stromal tumors are very rarely noted in association. In this study, we report the case of a 50-year-old man with genetically confirmed FAP and adenocarcinoma of the colon who was incidentally found to have a testicular lesion. Radial orchiectomy was performed, and histopathologic examination confirmed a Sertoli cell tumor without high-risk features. This tumor was found to have diffuse expression of nuclear beta-catenin, a marker for Wnt pathway activation, suggesting an abnormal CTNNB1 or APC variant. 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