{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:00Z","timestamp":1784869320628,"version":"3.55.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"\n Purpose<\/jats:title>\n Tumour hypoxia causes resistance against radiotherapy and chemotherapy in locally advanced cervical cancer (LACC). Non-invasive magnetic resonance imaging (MRI) biomarkers have the potential to guide hypoxia-targeted therapy but require technical development and validation. This study evaluated the feasibility and early treatment response monitoring capabilities of oxygen-enhanced MRI (OE-MRI) in healthy female volunteers and patients with LACC.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Healthy volunteers underwent OE-MRI to demonstrate the feasibility of the technique and to compare the onset, magnitude, and duration of change in longitudinal relaxation rate (\u0394\n R<\/jats:italic>\n 1<\/jats:sub>\n ) for breathing either 100% oxygen or carbogen. Uterine cervix and body tissues were examined. Next, patients with biopsy-proven LACC underwent OE-MRI pre-treatment, and then, at 3 and 5 weeks into chemotherapy, it was combined with external beam radiotherapy.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Feasibility was demonstrated in 97% (31\/32) of uterine tissue regions of interest, measured in 18 volunteers. \u0394\n R<\/jats:italic>\n 1<\/jats:sub>\n values in the uterine cervix and body were similar across gas types with a cohort \u0394\n R<\/jats:italic>\n 1<\/jats:sub>\n of between 0.026 and 0.033 s\n \u22121<\/jats:sup>\n . In patients with LACC, significant increases in tumour \u0394\n R<\/jats:italic>\n 1<\/jats:sub>\n were observed during treatment by week 3 (mean increase, 0.0143 s\n \u22121<\/jats:sup>\n ; 95% CI 0.0014 to 0.0273;\n p<\/jats:italic>\n \u00a0=\u00a00.035). At week 5, six of eight evaluable patients showed a &gt;50% treatment-associated increase in tumour \u0394\n R<\/jats:italic>\n 1<\/jats:sub>\n . Changes persisted in most patients to the end of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This first dedicated OE-MRI study in cervical cancer shows technique feasibility in healthy volunteers and patients with LACC. Treatment-associated increases in tumour \u0394\n R<\/jats:italic>\n 1<\/jats:sub>\n were demonstrated during chemoradiotherapy and likely reflect hypoxia modification. These findings support further evaluation of OE-MRI alongside independent hypoxia biomarkers in larger cervical cancer cohorts.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fonc.2026.1859532","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:23:15Z","timestamp":1784866995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxygen-enhanced MRI in patients with uterine cervical carcinoma: feasibility and treatment-associated changes in tumour oxygen-enhanced response"],"prefix":"10.3389","volume":"16","author":[{"given":"Anubhav","family":"Datta","sequence":"first","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]},{"name":"Clinical Radiology, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Dubec","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]},{"name":"Christie Medical Physics and Engineering, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berks","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A.","family":"Little","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Barraclough","sequence":"additional","affiliation":[{"name":"Clinical Oncology, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Haslett","sequence":"additional","affiliation":[{"name":"Clinical Oncology, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Porta","sequence":"additional","affiliation":[{"name":"Clinical Trials and Statistics Unit, The Institute of Cancer Research","place":["London, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Clinical Radiology, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Christie Medical Physics and Engineering, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]},{"name":"Biomedical Imaging, University of Leeds","place":["Leeds, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine","family":"West","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]},{"name":"Clinical Oncology, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hoskin","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, University of Manchester","place":["Manchester, United Kingdom"]},{"name":"Clinical Oncology, The Christie NHS Foundation Trust","place":["Manchester, United Kingdom"]},{"name":"Clinical Oncology, Mount Vernon Cancer Centre","place":["Northwood, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P. 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