{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:05:52Z","timestamp":1780549552367,"version":"3.54.1"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Splenic tumors are infrequently encountered in clinical practice, with a metastatic tumor incidence estimated to be approximately 2%-4% of all splenic tumors. Metastatic tumors originating from the liver are even more uncommon. Given the scarcity of reported cases and limited literature on splenic tumors, particularly in recent years, clinicians face significant challenges in effectively managing this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>In this report, we present a case of a malignant splenic tumor originating from the liver. The patient, a 58-year-old male, was admitted to our hospital over a week after the identification of a splenic mass. Notably, the patient had previously undergone liver cancer surgery at our institution two years prior. The current diagnosis is recurrent liver cancer, secondary malignant tumor of the spleen, and gallbladder stones. Based on the patient\u2019s clinical presentation, physical examination findings, and additional diagnostic tests, we performed a surgical procedure known as \u201c left hepatic lateral lobectomy, splenectomy and cholecystectomy\u201d. The postoperative pathological analysis confirmed the presence of recurrent hepatocellular carcinoma with splenic metastasis. Up to the last follow-up, the patient was in stable general condition without obvious discomfort and remained alive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining domestic and international literature, we now report a case of splenic malignancy of hepatic origin. In this case report, we aim to present its differential diagnosis and treatment options for clinicians\u2019 reference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1863458","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:31:00Z","timestamp":1780547460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of splenic malignancy originating from the liver"],"prefix":"10.3389","volume":"16","author":[{"given":"Lei","family":"Shen","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20160054","article-title":"The value of contrast-enhanced dynamic and diffusion-weighted MR imaging for distinguishing benign and Malignant splenic masses","volume":"89","author":"Choi","year":"2016","journal-title":"Br J Radiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/219297","article-title":"The spleen revisited: an overview on magnetic resonance imaging","volume":"2013","author":"Palas","year":"2013","journal-title":"Radiol Res Pract"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2010.0026","article-title":"Primary and secondary neoplasms of the spleen","volume":"10","author":"Kaza","year":"2010","journal-title":"Cancer Imaging"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0526-MTTTS","article-title":"Metastatic tumors to the spleen: a 25-year clinicopathologic study","volume":"124","author":"Lam","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199210000-00017","article-title":"Isolated splenic metastasis from rectal carcinoma","volume":"85","author":"Capizzi","year":"1992","journal-title":"South Med J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.clinimag.2017.10.020","article-title":"Contrast-enhanced imaging features and differentiation of benign and Malignant focal splenic lesions","volume":"49","author":"Cao","year":"2018","journal-title":"Clin Imaging"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.5.930","article-title":"Role of CT in differentiating Malignant focal splenic lesions","volume":"19","author":"Jang","year":"2018","journal-title":"Korean J Radiol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1863458\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:31:04Z","timestamp":1780547464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1863458\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":8,"alternative-id":["10.3389\/fonc.2026.1863458"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1863458","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"article-number":"1863458"}}