{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:00:20Z","timestamp":1785308420394,"version":"3.55.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Gastric inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of intermediate biological potential, with adult cases being particularly uncommon. We report a 64-year-old man with an incidentally detected gastric mass that was preoperatively suspected to be a gastrointestinal stromal tumor (GIST). The relevant literature on adult gastric IMT was also reviewed. Complete surgical resection with negative margins (R0 resection) remains the mainstay of treatment, whereas patients with confirmed ALK rearrangements may benefit from ALK inhibitor therapy. Histopathological confirmation and long-term surveillance are essential because of the potential for recurrence and occasional aggressive behavior.<\/jats:p>","DOI":"10.3389\/fonc.2026.1865679","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:02:47Z","timestamp":1785304967000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric inflammatory myofibroblastic tumor in adults: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhenxuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Yangtze University, The First People\u2019s Hospital of Jingzhou","place":["Jingzhou, China"]},{"name":"The First School of Clinical Medicine, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Yangtze University, The First People\u2019s Hospital of Jingzhou","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gu","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Yangtze University, The First People\u2019s Hospital of Jingzhou","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","volume-title":"Digestive System Tumours","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880210","article-title":"Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT)","volume":"13","author":"Miettinen","year":"2000","journal-title":"Mod Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-021-00254-5","article-title":"Gastrointestinal stromal tumours","volume":"7","author":"Blay","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000001416","article-title":"A diagnosis of gastric inflammatory myofibroblast tumor: A challenge like no other","volume":"11","author":"Chukkalore","year":"2024","journal-title":"ACG Case Rep J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824644ac","article-title":"Malignant gastrointestinal neuroectodermal tumor: Clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of 16 cases with a reappraisal of clear cell sarcoma-like tumors of the gastrointestinal tract","volume":"36","author":"Stockman","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13061131","article-title":"The Malignant gastrointestinal neuroectodermal tumor (GNET): A distinct entity and the challenging differential diagnosis with mesenchymal, lymphoid, and melanic tumors: a case report and brief review of the literature","volume":"13","author":"Bo\u0219oteanu","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-023-14712-9","article-title":"Management of gastric neuroendocrine tumors: A review","volume":"31","author":"Sok","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-024-01204-5","article-title":"Molecular heterogeneity in leiomyosarcoma and implications for personalised medicine","volume":"25","author":"Arfan","year":"2024","journal-title":"Curr Treat Options Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-019-00269-y","article-title":"Primary gastric leiomyosarcoma: A case report and review of the literature","volume":"51","author":"Garg","year":"2020","journal-title":"J Gastrointest Cancer"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12662","article-title":"Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: A case report and review of literature","volume":"68","author":"Kitagawa","year":"2018","journal-title":"Pathol Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200109000-00002","article-title":"Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: A clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases","volume":"25","author":"Miettinen","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01144-6","article-title":"Update of diagnosis and targeted therapy for ALK+ inflammation myofibroblastic tumor","volume":"24","author":"Qa","year":"2023","journal-title":"Curr Treat Options Oncol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"899","DOI":"10.4143\/crt.2024.1184","article-title":"ALK inhibition in a patient with inflammatory myofibroblastic tumor harboring CARS1-ALK fusion","volume":"57","author":"Choi","year":"2025","journal-title":"Cancer Res Treat"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.32604\/or.2024.050350","article-title":"Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment","volume":"32","author":"Chmiel","year":"2024","journal-title":"Oncol Res"},{"key":"B15","unstructured":"Search Orphan Drug Designations and Approvals"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17081327","article-title":"Inflammatory myofibroblastic tumor: An updated review","volume":"17","author":"Choi","year":"2025","journal-title":"Cancers (Basel)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12032-018-1161-0","article-title":"Clinical and histopathologic correlates and management strategies for inflammatory myofibroblastic tumor of the lung. A case series and review of the literature","volume":"35","author":"Sagar","year":"2018","journal-title":"Med Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14914","article-title":"Surgical treatment for lung metastasis of inflammatory myofibroblastic tumor of the lung: A case report","volume":"14","author":"Iwai","year":"2023","journal-title":"Thorac Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.69","article-title":"Inflammatory myofibroblastic tumor of the uterus: A clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum","volume":"30","author":"Bennett","year":"2017","journal-title":"Mod Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/pbc.20294","article-title":"Pediatric inflammatory myofibroblastic tumor: Anaplastic lymphoma kinase (ALK) expression and prognosis","volume":"45","author":"Chun","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213393.57322.c7","article-title":"Inflammatory myofibroblastic tumor: Comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases","volume":"31","author":"Coffin","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/path.4836","article-title":"ALK oncoproteins in atypical inflammatory myofibroblastic tumours: Novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma","volume":"241","author":"Lee","year":"2017","journal-title":"J Pathol"},{"key":"B23","article-title":"ALK negative primary gastric inflammatory myofibroblastic tumor: report of a case","volume":"44","author":"Wei","year":"2015","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37167","article-title":"A giant solid-cystic gastric inflammatory myofibroblastic tumor: A case report and literature review","volume":"15","author":"Desai","year":"2023","journal-title":"Cureus"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2761","article-title":"A large inflammatory myofibroblastic tumor involving both stomach and spleen: A case report and review of the literature","volume":"9","author":"Chen","year":"2015","journal-title":"Oncol Lett"},{"key":"B26","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13000-017-0645-0","article-title":"ALK-positive gastric inflammatory myofibroblastic tumor in an adult with familial adenomatous polyposis and diffuse fundic polyposis","volume":"12","author":"Fan","year":"2017","journal-title":"Diagn Pathol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3892\/ol.2020.12312","article-title":"Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a university hospital in China","volume":"21","author":"Song","year":"2020","journal-title":"Oncol Lett"},{"key":"B28","doi-asserted-by":"publisher","first-page":"948","DOI":"10.3892\/etm.2021.10380","article-title":"Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases","volume":"22","author":"Wang","year":"2021","journal-title":"Exp Ther Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12780","article-title":"Computed tomographic features of inflammatory myofibroblastic tumour of the stomach in adult patients: An analysis of five multicentre cases with literature review","volume":"62","author":"Lee","year":"2018","journal-title":"J Med Imag Rad Onc"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2018.1480290","article-title":"Double amplifications of CDK4 and MDM2 in a gastric inflammatory myofibroblastic tumor mimicking cancer with local invasion of the spleen and diaphragm","volume":"19","author":"He","year":"2018","journal-title":"Cancer Biol Ther"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.136","article-title":"Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman: A rare cause of hemoperitoneum","volume":"14","author":"Park","year":"2008","journal-title":"WJG"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.15171\/mejdd.2016.19","article-title":"Fever, weight loss and early satiety due to gastric inflammatory myofibroblastic tumor; case report and literature review","volume":"8","author":"Mohammad Hoseini-Azar","year":"2016","journal-title":"Middle East J Dig Dis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13019-024-02481-9","article-title":"Gastric and cardiac inflammatory myofibroblastic tumor: An extremely rare case","volume":"19","author":"Huang","year":"2024","journal-title":"J Cardiothorac Surg"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.05.037","article-title":"Gastric inflammatory myofibroblastic tumor identified as ectopic pancreas and treated by endoscopic submucosal dissection","volume":"86","author":"Ning","year":"2017","journal-title":"Gastrointestinal Endoscopy"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1177\/03000605251314800","article-title":"Gastric inflammatory myofibroblastic tumor invading the esophagus and spleen: A rare case report and literature review","volume":"53","author":"Zou","year":"2025","journal-title":"J Int Med Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1244227","article-title":"Gastric inflammatory myofibroblastic tumor masquerading as a pancreatic cystic neoplasm","volume":"42","author":"Fong","year":"2010","journal-title":"Endoscopy"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40792-023-01802-9","article-title":"Gastric inflammatory myofibroblastic tumor presented with severe anemia and inflammation: A case report","volume":"10","author":"Hiramatsu","year":"2024","journal-title":"Surg Case Rep"},{"key":"B38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12957-018-1460-0","article-title":"Gastric inflammatory myofibroblastic tumor treated with combined laparoscopic and endoscopic gastric wedge resection: A case report","volume":"16","author":"Hayashi","year":"2018","journal-title":"World J Surg Onc"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v15.i11.2657","article-title":"Gastric inflammatory myofibroblastic tumor, a rare mesenchymal neoplasm: A case report","volume":"15","author":"Fernandez Rodriguez","year":"2023","journal-title":"World J Gastrointest Surg"},{"key":"B40","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40792-024-01844-7","article-title":"Gastric inflammatory myofibroblastic tumor: A case report","volume":"10","author":"Hattori","year":"2024","journal-title":"Surg Case Rep"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.48095\/ccrvch2025409","article-title":"Gastric inflammatory myofibroblastic tumour in a young adult","volume":"104","author":"Ho\u0161ala","year":"2025","journal-title":"Rozhl Chir"},{"key":"B42","article-title":"High fever as an initial symptom of primary gastric inflammatory myofibroblastic tumor in an adult woman","volume":"7","author":"Qiu","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1177\/030089161009600320","article-title":"Inflammatory myofibroblastic tumor of the stomach in an adult woman: A rare intermittent cause of gastric outlet obstruction","volume":"96","author":"Albayrak","year":"2010","journal-title":"Tumori"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2015.15.1.64","article-title":"Inflammatory myofibroblastic tumor treated with laparoscopic proximal gastrectomy and double-tract anastomosis","volume":"15","author":"Kim","year":"2015","journal-title":"J Gastric Cancer"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/328108","article-title":"Inflammatory myofibroblastic tumor: A rarely seen submucosal lesion of the stomach","volume":"2013","author":"Arslan","year":"2013","journal-title":"Case Rep Oncological Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s13193-014-0296-5","article-title":"Primary gastric inflammatory myofibroblastic tumor in an adult\u2014case report with brief review","volume":"5","author":"Katakwar","year":"2014","journal-title":"Indian J Surg Oncol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.09.002","article-title":"Primary gastric inflammatory myofibroblastic tumor: A clinicopathologic and immunohistochemical study of 5 cases","volume":"206","author":"Shi","year":"2010","journal-title":"Pathol Res Pract"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.5867\/medwave.2022.10.2529","article-title":"Primary gastric myofibroblastic tumor in an adult at Per\u00fa: Case report and literature review","volume":"22","author":"Flores-Trujillo","year":"2022","journal-title":"Medwave"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1126_20","article-title":"Primary inflammatory myofibroblastic tumor of stomach\u2014report of a very rare case","volume":"10","author":"Hajong","year":"2021","journal-title":"J Family Med Primary Care"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/374070","article-title":"Rare gastric inflammatory myofibroblastic tumor in an adult woman: A case report with review of the literature","volume":"2012","author":"Ribeiro","year":"2012","journal-title":"Case Rep Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.110262","article-title":"Unusual gastric localization of an inflammatory myofibroblastic tumor: a case report and review of the literature","volume":"123","author":"Laamiri","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.243","article-title":"Primary gastric inflammatory myofibroblastic tumor treated with non\u2010exposed endoscopic wall\u2010inversion surgery (NEWS): a case report and literature review","volume":"4","author":"Masuda","year":"2024","journal-title":"Den Open"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013423","article-title":"Primary gastric inflammatory myofibroblastic tumor: a case report","volume":"97","author":"Cheng","year":"2018","journal-title":"Medicine"},{"key":"B54","doi-asserted-by":"publisher","first-page":"399","DOI":"10.4318\/tjg.2012.0399","article-title":"Inflammatory myofibroblastic tumor of the stomach in an adult female - report of a rare case and review of the literature","volume":"23","author":"Jain","year":"2012","journal-title":"Turk J Gastroenterol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.5146\/tjpath.2017.01388","article-title":"Inflammatory myofibroblastic tumor of the stomach presenting as an exophytic mass - a diagnostic dilemma","volume":"35","author":"Jadhav","year":"2019","journal-title":"Turk Patoloji Derg"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-003-0085-z","article-title":"Inflammatory myofibroblastic tumor of the stomach with peritoneal dissemination in a young adult: imaging findings in a case report","volume":"29","author":"Kim","year":"2004","journal-title":"Abdom Imaging"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.09.026","article-title":"Inflammatory myofibroblastic tumor of the stomach: an unusual complication after gastrectomy","volume":"63","author":"Leon","year":"2006","journal-title":"Gastrointestinal Endoscopy"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-35","article-title":"Primary inflammatory myofibroblastic tumor of the stomach in an adult woman: a case report and review of the literature","volume":"11","author":"Bjelovic","year":"2013","journal-title":"World J Surg Onc"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1865679\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:02:54Z","timestamp":1785304974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1865679\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":58,"alternative-id":["10.3389\/fonc.2026.1865679"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1865679","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"article-number":"1865679"}}