{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:45:56Z","timestamp":1782708356731,"version":"3.54.5"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Mucosa-associated lymphoid tissue (MALT) lymphoma represents an indolent form of non-Hodgkin lymphoma, predominantly arising in the gastrointestinal tract, particularly the stomach, with rare occurrences reported in the urinary tract. Its etiology is closely associated with chronic antigenic stimulation, commonly linked to persistent infections such as\n                    <jats:italic>H. pylori<\/jats:italic>\n                    , autoimmune conditions, or underlying genetic susceptibility. This report details a unique case of a married couple diagnosed with primary MALT lymphoma at separate anatomical sites\u2014ileocecal region in the husband and urethra in the wife\u2014within a span of one year. Both individuals attained complete remission following rituximab-based immunotherapy, supplemented by radiotherapy in wife case. The development of lymphoma in married couples, whether presenting with identical or distinct pathological subtypes, is exceptionally uncommon and frequently suggests potential shared environmental or infectious exposures.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1870719","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:26:05Z","timestamp":1782707165000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous mucosa-associated lymphoid tissue lymphoma in a married couple: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Mo","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Li","sequence":"additional","affiliation":[{"name":"Gastric Cancer Center, Division of Medical Oncology, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21037\/aol-20-28","article-title":"Epidemiology of marginal zone lymphoma","volume":"5","author":"Cerhan","year":"2021","journal-title":"Ann Lymphoma"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000502204","article-title":"Mucosa-associated lymphoid tissue lymphoma of the thyroid gland: a systematic review of the literature","volume":"9","author":"Karvounis","year":"2020","journal-title":"Eur Thyroid J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.4.1182","article-title":"T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear 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Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1870719\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:26:05Z","timestamp":1782707165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1870719\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":10,"alternative-id":["10.3389\/fonc.2026.1870719"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1870719","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"article-number":"1870719"}}