{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:43:32Z","timestamp":1785908612793,"version":"3.56.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>The extent of resection required for duodenal malignancy has long been debatable. Compared with pancreaticoduodenectomy (PD), pancreas-preserving segmental duodenectomy (PPSD) is a less demolitive procedure that provides definitive treatment for a range of duodenal pathologies, including adenocarcinoma. However, the rarity of these malignancies limits large-scale clinical studies on the feasibility and safety of PPSD. Thus, case reports and small case series may provide some clinical guidance for this rare situation. We herein report two cases of patients with duodenal malignancy who were treated with PPSD. Case 1 was a 36-year-old female patient, who was diagnosed with adenocarcinoma of the hepatic flexure with synchronous invasion of the descending portion of the duodenum. After 4 cycles of neoadjuvant chemotherapy, she received radical right colectomy and PPSD. Case 2 was a 45-year-old male patient, who was found to have a metachronous metastasis in the horizontal portion of the duodenum 14 months after laparoscopic extended right colectomy with complete mesocolic excision for transverse colon adenocarcinoma. The duodenal lesion was confirmed by imaging, endoscopic, and pathological examinations. He received PPSD combined with a partial resection of the uncinate process of the pancreas. Postoperative pathology confirmed R0 resection in both cases, and both patients had an uneventful recovery. These cases provide further evidence supporting the feasibility and safety of PPSD for non-ampullary duodenal tumors. However, the long-term oncological outcomes are still unclear; therefore, further studies with longer follow-up and larger sample sizes are warranted.<\/jats:p>","DOI":"10.3389\/fonc.2026.1872839","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:43:23Z","timestamp":1785905003000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreas-preserving segmental duodenectomy for duodenal malignancy: two case reports"],"prefix":"10.3389","volume":"16","author":[{"given":"Junpeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longchang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuxin","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanda","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v14.i11.1219","article-title":"Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum","volume":"14","author":"Nishio","year":"2022","journal-title":"World J Gastrointest Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106599","article-title":"Long-term results after resection of primary duodenal adenocarcinoma: a retrospective cohort study","volume":"100","author":"Jensen","year":"2022","journal-title":"Int J Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-016-1537-6","article-title":"Surgical treatment of neuroendocrine tumors in the second portion of the duodenum: a single center experience and systematic review of the literature","volume":"402","author":"Iwasaki","year":"2017","journal-title":"Langenbecks Arch Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01840-5","article-title":"Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis","volume":"26","author":"Burasakarn","year":"2021","journal-title":"Int J Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0043","article-title":"Small bowel adenocarcinoma, version 1.2020, NCCN clinical practice guidelines in oncology","volume":"17","author":"Benson","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6567-6","article-title":"Outcomes and treatment options for duodenal adenocarcinoma: a systematic review and meta-analysis","volume":"25","author":"Meijer","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4020-z","article-title":"Does the extent of resection impact survival for duodenal adenocarcinoma? 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