{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:49Z","timestamp":1790834509228,"version":"4.1.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) is a malignant tumor characterized by high recurrence and metastasis rates, as well as a poor prognosis. Cuproptosis is a form of programmed cell death driven by abnormal copper-ion metabolism. Existing studies have shown that its occurrence is closely regulated and associated with the progression of HCC. However, it is still unclear how long non-coding RNAs (lncRNAs) control the process in HCC. The purpose of this work is to clarify how the lncRNA AP003469.2 influences cuproptosis and promotes the development of HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study utilized RNA sequencing data from the TCGA-LIHC dataset to screen for cuproptosis-related lncRNAs exhibiting significant expression differences. Following the initial screening, the expression of lncRNA AP003469.2 was validated using qRT-PCR. Subsequent\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      studies confirmed AP003469.2\u2019s biological role in HCC. To understand the fundamental mechanisms, we determined the subcellular localization of the proteins using nuclear\u2013cytoplasmic fractionation and fluorescence\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization (FISH). The regulatory relationships between miR-4732-3p and LIPT1 and between AP003469.2 and miR-4732-3p were then verified using dual-luciferase reporter assays. In addition, we utilized Western blotting, copper assays, CCK-8, and immunohistochemistry to evaluate related proteins and markers indicative of cuproptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A poor prognosis was observed to be positively correlated with elevated expression of AP003469.2 in HCC. In both\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      experimental methods, AP003469.2 stimulated important malignant characteristics in HCC cells, including invasion, migration, and proliferation. Furthermore, by controlling LIPT1 expression and modulating copper homeostasis and important proteins, including FDX1, SLC31A1, and HSP70, AP003469.2 acts as a molecular sponge for miR-4732-3p, attenuating cuproptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our research demonstrated that the AP003469.2\/miR-4732-3p\/LIPT1 axis could suppress cuproptosis to promote HCC progression. Therefore, AP003469.2 may serve as a target for HCC treatment or diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1874176","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:42:13Z","timestamp":1790833333000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["LncRNA AP003469.2 promotes hepatocellular carcinoma progression by regulating cuproptosis via the miR-4732-3p\/LIPT1 axis"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinlong","family":"Huo","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery, The Third Affiliated Hospital of Zunyi Medical University (The First People\u2019s Hospital of Zunyi)","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuman","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"Guizhou Provincial Key Laboratory of Digestive System Diseases","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"Guizhou Provincial Key Laboratory of Digestive System Diseases","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Third Affiliated Hospital of Zunyi Medical University (The First People\u2019s Hospital of Zunyi)","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41392-020-00375-5","article-title":"CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1","volume":"5","author":"Xu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00825-3","article-title":"Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy","volume":"20","author":"Singal","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.05.009","article-title":"Bruceine D inhibits HIF-1alpha-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT\/beta-catenin interaction","volume":"11","author":"Huang","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"6314","DOI":"10.1038\/s41467-021-26718-6","article-title":"N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1021\/es204027m","article-title":"Inhibition of copper uptake in yeast reveals the copper transporter Ctr1p as a potential molecular target of saxitoxin","volume":"46","author":"Cusick","year":"2012","journal-title":"Environ Sci Technol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105622","article-title":"Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index","volume":"138","author":"Cadiou","year":"2020","journal-title":"Environ Int"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39471","article-title":"Ultrasmall CuS@BSA nanoparticles with mild photothermal conversion synergistically induce MSCs-differentiated fibroblast and improve skin regeneration","volume":"10","author":"Xiao","year":"2020","journal-title":"Theranostics"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat Rev Clin Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s13046-025-03486-5","article-title":"Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer","volume":"44","author":"Suwara","year":"2025","journal-title":"J Exp Clin Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6523","DOI":"10.1038\/s41467-023-42025-8","article-title":"Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408106","article-title":"AKT1 phosphorylates FDX1 to promote cuproptosis resistance in triple-negative breast cancer","volume":"12","author":"Sun","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12967-022-03630-1","article-title":"System analysis based on the cuproptosis-related genes identifies LIPT1 as a novel therapy target for liver hepatocellular carcinoma","volume":"20","author":"Yan","year":"2022","journal-title":"J Transl Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s40364-024-00677-8","article-title":"Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy","volume":"12","author":"Zhang","year":"2024","journal-title":"biomark Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","article-title":"Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research","volume":"15","author":"Tong","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13276","article-title":"Copper homeostasis and cuproptosis in cancer immunity and therapy","volume":"321","author":"Liu","year":"2024","journal-title":"Immunol Rev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.34133\/research.0698","article-title":"Unveiling the cuproptosis in colitis and colitis-related carcinogenesis: A multifaceted player and immune moderator","volume":"8","author":"Liu","year":"2025","journal-title":"Res (Wash D C)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13062-023-00358-w","article-title":"Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma","volume":"18","author":"Chen","year":"2023","journal-title":"Biol Direct"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-023-2755-0","article-title":"DLAT as a cuproptosis promoter and a molecular target of elesclomol in hepatocellular carcinoma","volume":"43","author":"Gao","year":"2023","journal-title":"Curr Med Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-23-685","article-title":"Identification of cuproptosis and ferroptosis-related subgroups and development of a signature for predicting prognosis and tumor microenvironment landscape in hepatocellular carcinoma","volume":"12","author":"Yang","year":"2023","journal-title":"Transl Cancer Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jare.2024.10.026","article-title":"Multiple roles of p53 in cancer development: Regulation of tumor microenvironment, m(6)A modification and diverse cell death mechanisms","volume":"75","author":"Wang","year":"2024","journal-title":"J Adv Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1584811","article-title":"p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation","volume":"15","author":"Liu","year":"2025","journal-title":"Front Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101766","article-title":"The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis","volume":"38","author":"Liu","year":"2021","journal-title":"Redox Biol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.908","article-title":"LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice","volume":"12","author":"Liu","year":"2022","journal-title":"Clin Transl Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab030","article-title":"PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiation","volume":"49","author":"Xu","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41419-023-05790-4","article-title":"LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1alpha\/NF-kappaB axis in psoriasis","volume":"14","author":"Hu","year":"2023","journal-title":"Cell Death Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.02.008","article-title":"Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities","volume":"31","author":"Srinivas","year":"2023","journal-title":"Mol Ther"},{"key":"B30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12943-024-01944-w","article-title":"ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK\/PI3K\/AKT activation in a ceRNA manner","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111389","article-title":"The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression","volume":"137","author":"Su","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.66917","article-title":"Ferroptosis in cancer progression: role of noncoding RNAs","volume":"18","author":"Zuo","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s11658-024-00560-2","article-title":"Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer","volume":"29","author":"Xiang","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103722","article-title":"LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer","volume":"85","author":"Ma","year":"2025","journal-title":"Redox Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118305","article-title":"LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53","volume":"260","author":"Lu","year":"2020","journal-title":"Life Sci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41368-024-00314-y","article-title":"Cuproptosis-related lncRNA JPX regulates Malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p\/PLAU axis","volume":"16","author":"Sun","year":"2024","journal-title":"Int J Oral Sci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.11.021","article-title":"lncRNA UCA1 Functions as a ceRNA to Promote Prostate Cancer Progression via Sponging miR143","volume":"19","author":"Yu","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00696-7","article-title":"m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p\u2013AQP1\/ANKH axis","volume":"53","author":"Yang","year":"2021","journal-title":"Exp Mol Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13046-023-02720-2","article-title":"Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer","volume":"42","author":"Wang","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s11658-024-00623-4","article-title":"Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer","volume":"29","author":"Xiao","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.98806","article-title":"Elucidating the evolving role of cuproptosis in breast cancer progression","volume":"20","author":"Zhu","year":"2024","journal-title":"Int J Biol Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf130","article-title":"SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis","volume":"46","author":"Tu","year":"2025","journal-title":"Eur Heart J"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2024","article-title":"Mammalian copper homeostasis: physiological roles and molecular mechanisms","volume":"105","author":"Lutsenko","year":"2025","journal-title":"Physiol Rev"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2025.05.019","article-title":"Integrative analysis of copper dysregulation and cuproptosis in postnatal hematopoiesis","volume":"70","author":"Chen","year":"2025","journal-title":"Sci Bull (Beijing)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2200554","article-title":"Copper metabolism in cell death and autophagy","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202417616","article-title":"A mitochondria-targeted nanozyme platform for multi-pathway tumor therapy via ferroptosis and cuproptosis regulation","volume":"12","author":"Liu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3390\/cells14070509","article-title":"Hsp70: A multifunctional chaperone in maintaining proteostasis and its implications in human disease","volume":"14","author":"Singh","year":"2025","journal-title":"Cells"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.10.042","article-title":"Functional long non-coding RNAs in hepatocellular carcinoma","volume":"500","author":"Xie","year":"2021","journal-title":"Cancer Lett"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00616-7","article-title":"Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma","volume":"4","author":"Liu","year":"2022","journal-title":"Nat Metab"},{"key":"B50","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13046-021-02197-x","article-title":"Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p\/ST6GAL1\/NF-kappaB pathway","volume":"41","author":"Mei","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B51","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41421-021-00339-1","article-title":"LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation","volume":"7","author":"Liang","year":"2021","journal-title":"Cell Discov"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.02.020","article-title":"Long noncoding RNA LINC01234 promotes hepatocellular carcinoma progression through orchestrating aspartate metabolic reprogramming","volume":"30","author":"Chen","year":"2022","journal-title":"Mol Ther"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.11.001","article-title":"Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b\/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma","volume":"469","author":"Ye","year":"2020","journal-title":"Cancer Lett"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad114","article-title":"Intrapericardial long non-coding RNA-Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair","volume":"44","author":"Zhu","year":"2023","journal-title":"Eur Heart J"},{"key":"B55","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12943-020-01174-w","article-title":"MIR22HG acts as a tumor suppressor via TGFbeta\/SMAD signaling and facilitates immunotherapy in colorectal cancer","volume":"19","author":"Xu","year":"2020","journal-title":"Mol Cancer"},{"key":"B56","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13046-023-02774-2","article-title":"LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a\/RREB1 positive feedback loop and a ceRNA network","volume":"42","author":"Dong","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"B57","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12943-022-01546-4","article-title":"Characterization of distinct circular RNA signatures in solid tumors","volume":"21","author":"Wang","year":"2022","journal-title":"Mol Cancer"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305902","article-title":"A mammalian conserved circular RNA CircLARP1B regulates hepatocellular carcinoma metastasis and lipid metabolism","volume":"11","author":"Li","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1038\/s41467-021-22337-3","article-title":"A KRAS-responsive long non-coding RNA controls microRNA processing","volume":"12","author":"Shi","year":"2021","journal-title":"Nat Commun"},{"key":"B60","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13045-021-01210-2","article-title":"Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p\/CTBP2\/E-cadherin axis in colorectal cancer","volume":"14","author":"He","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05325-6","article-title":"Aberrant expression of cuproptosis-related gene LIPT1 is associated with metabolic dysregulation of fatty acid and prognosis in hepatocellular carcinoma","volume":"149","author":"Li","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.729340","article-title":"Tumor mutation burden-associated LINC00638\/miR-4732-3p\/ULBP1 axis promotes immune escape via PD-L1 in hepatocellular carcinoma","volume":"11","author":"Qi","year":"2021","journal-title":"Front Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1874176\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:42:15Z","timestamp":1790833335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1874176\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":62,"alternative-id":["10.3389\/fonc.2026.1874176"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1874176","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"1874176"}}