{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:13:38Z","timestamp":1783660418550,"version":"3.55.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"\n Background<\/jats:title>\n Cervical squamous cell carcinoma (CSCC) rarely presents with urinary system symptoms as the initial manifestation. When the tumor invades the bladder trigone, it may mimic primary urologic disease. We report a case with pathologically confirmed bladder invasion.<\/jats:p>\n <\/jats:sec>\n \n Case<\/jats:title>\n A 74-year-old woman with a history of left lung adenocarcinoma resection (pT1bN0M0, stage IA2) presented with anuria, bilateral hydronephrosis, and fever. Initial workup revealed acute kidney injury (creatinine 720.5 \u03bcmol\/L) and severe urinary tract infection. Emergency bilateral ureteral stenting and transurethral bladder biopsy were performed. Transurethral biopsy showed squamous epithelial hyperplasia with focal atypia; immunohistochemistry (IHC) revealed CD34+, GATA3 focal weak+, CK7+, CK20\u2212, P63+, Ki-67 15%, insufficient for definitive malignancy. Persistent hydronephrosis prompted laparoscopic exploration in July 2023.\u00a0A biopsy taken from the vesicouterine junction (interface between bladder and uterus) showed invasive squamous cell carcinoma with diffuse p16 positivity (CK7+\/CK20\u2212\/P63+), providing pathological confirmation of bladder wall invasion by cervical cancer. Gynecologic consultation then identified a 2.5\u00a0cm cervical mass with contact bleeding, and cervical biopsy confirmed moderately differentiated CSCC with diffuse p16 block positivity. Staging imaging demonstrated a radiologically presumed isolated 4.2 \u00d7 2.5\u00a0cm right adrenal metastasis without other distant metastases. Final clinical diagnosis: HPV-associated CSCC, clinical FIGO stage IVB (pathologically confirmed bladder invasion, radiologically presumed adrenal metastasis without histologic confirmation). The patient underwent palliative ileal conduit urinary diversion, which provided short-term renal function improvement; she died 2 months after definitive diagnosis due to widespread disease progression.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n CSCC presenting with obstructive uropathy is rare and easily misdiagnosed. Gynecologic history taking and pelvic examination are imperative for female patients, and should be performed promptly, especially in the setting of adjacent organ lesions. The combination of imaging evidence of anatomical continuity and CK7+\/CK20\u2212\/P63+\/p16+ IHC profile has auxiliary value for differential diagnosis. Comprehensive staging including adrenal evaluation is essential. Early palliative urinary diversion may provide temporary relief in selected patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fonc.2026.1874217","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:24:23Z","timestamp":1783657463000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion"],"prefix":"10.3389","volume":"16","author":[{"given":"Yaxiong","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Urology, The First People\u2019s Hospital of Neijiang","place":["Neijiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Neijiang","place":["Neijiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Neijiang","place":["Neijiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First People\u2019s Hospital of Neijiang","place":["Neijiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2016.27.e43","article-title":"Advances in diagnosis and treatment of metastatic cervical 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morphological appearances encountered in human papillomavirus-associated and papillomavirus-independent tumors and precursor lesions","volume":"31","author":"Stolnicu","year":"2024","journal-title":"Adv Anat Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.09.001","article-title":"HPV-positive clinically advanced squamous cell carcinoma (aBSCC): a comprehensive genomic profiling (CGP) study","volume":"41","author":"Ghelani","year":"2023","journal-title":"Urol Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01387.x","article-title":"Keratin expression in human tissues and neoplasms","volume":"40","author":"Chu","year":"2002","journal-title":"Histopathology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32070394","article-title":"Survival outcomes in patients with squamous cell carcinoma of the urinary bladder: a propensity score-matched 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Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1874217\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:24:24Z","timestamp":1783657464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1874217\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":9,"alternative-id":["10.3389\/fonc.2026.1874217"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1874217","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"article-number":"1874217"}}