{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:46:01Z","timestamp":1782708361714,"version":"3.54.5"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Non-gestational choriocarcinoma (NGCC) is a rare and highly aggressive malignancy in male patients and is frequently diagnosed at an advanced stage because of its atypical clinical manifestations. We report the case of a 38-year-old male patient who presented a unilateral cervical tumor without associated genitourinary symptoms. Histopathological examination combined with immunohistochemical analysis subsequently confirmed the diagnosis of NGCC. Radiologic assessment demonstrated extensive lymph node involvement without identification of a definite primary lesion. The patient initially showed a transient response following platinum-based chemotherapy, followed by disease progression during follow-up. This case highlights the importance of including NGCC in the differential diagnosis when male patients present with unexplained cervical lymphadenopathy, hemorrhagic and necrotic poorly differentiated tumors, and elevated \u03b2-human chorionic gonadotropin (\u03b2-hCG) levels. Early recognition together with comprehensive immunohistochemical evaluation and systemic imaging assessment is essential to reduce diagnostic delay.<\/jats:p>","DOI":"10.3389\/fonc.2026.1874261","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:26:28Z","timestamp":1782707188000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-gestational choriocarcinoma presenting as cervical lymphadenopathy in a male patient: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoming","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, Anhui, China"]},{"name":"Department of Oncology, Anhui Public Health Clinical Center","place":["Hefei, Anhui, 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