{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:00:37Z","timestamp":1785128437887,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Extragonadal non-gestational choriocarcinama, especially in the gastrointestinal tract, is exceptionally rare. It often presents with metastatic disease and nonspecific symptoms, leading to diagnostic delays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>Herein, we reported a 61-year-old male patient diagnosed with small intestine choriocarcinoma with metastases of brain, lung, liver and lymph nodes. This patient presented initially with black stools, heart palpitations and chest tightness. After diagnosis, the patient received chemotherapy with etoposide and cisplatin. The patient demonstrated a robust clinical and biochemical response to chemotherapy, with a significant reduction in \u03b2-HCG levels and increase of hemoglobin. Follow\u2010up imaging demonstrated a decreased size of pulmonary and liver metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Because of the complex nature of extragonadal non-gestational choriocarcinama, diagnosis is often delayed. The present case highlight the necessity for high clinical suspicion, and early initiation of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1874971","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:26:08Z","timestamp":1785126368000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Small intestine choriocarcinoma with brain, lung and liver metastases in a male patient: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Huamei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayou","family":"Shi","sequence":"additional","affiliation":[{"name":"Oncology Department, Jiujiang City Key Laboratory of Cell Therapy, JiuJiang NO.1 People's 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