{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:03:48Z","timestamp":1789707828585,"version":"4.0.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To construct a predictive model for postoperative bladder paralysis in patients with cervical cancer (CC) based on Logistic regression and nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data of 220 patients with CC admitted to our hospital from December 2019 to September 2022 were retrospectively collected as the modeling cohort. In addition, the clinical data of 130 patients with CC admitted to the same hospital during a later time period, from October 2022 to September 2025, were collected as the temporal validation cohort. According to whether the patients in the modeling and validation cohorts developed bladder paralysis after surgery, they were separated into the bladder paralysis groups and the non-bladder paralysis groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Logistic regression analysis of the variables selected by LASSO regression showed that clinical staging, number of lymph nodes removed, extent of hysterectomy, width of parametrial tissue resection, and vaginal stump length were risk factors for postoperative bladder paralysis in patients with CC (P &amp;lt; 0.05). The AUC in the modeling cohort was 0.899, and 0.899, and the H-L test yielded \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a07.405 (P\u00a0=\u00a00.734). DCA showed a favorable net clinical benefit across threshold probabilities of 0.14\u20130.82. In the temporal validation cohort,the AUC was 0.944, and the H-L test yielded \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a07.234 (P\u00a0=\u00a00.725). DCA showed a favorable net clinical benefit across threshold probabilities of 0.19\u20130.84.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical staging, number of lymph nodes removed, extent of hysterectomy, width of parametrial tissue resection, and vaginal stump length were risk factors for postoperative bladder paralysis in patients with CC. The nomogram model constructed based on Logistic regression has good consistency and discrimination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1877348","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:33:01Z","timestamp":1789705981000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The construction of a predictive model for postoperative bladder paralysis in patients with cervical cancer based on logistic regression and nomogram"],"prefix":"10.3389","volume":"16","author":[{"given":"Lishan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gynecology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Meizhou People\u2019s Hospital","place":["Meizhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_862_16","article-title":"Oxidative stress and its role in cancer","volume":"17","author":"Jelic","year":"2021","journal-title":"J Cancer Res Ther"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.10.004","article-title":"APOBEC: A molecular driver in cervical cancer pathogenesis","volume":"496","author":"Revathidevi","year":"2020","journal-title":"Cancer Lett"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000001014","article-title":"Urodynamic assessment of bladder storage function after radical hysterectomy for cervical cancer","volume":"133","author":"Cao","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2022.05.018","article-title":"Objective and subjective assessment of bladder function after robot-assisted laparoscopic radical hysterectomy for early-stage cervical cancer","volume":"29","author":"Wallin","year":"2022","journal-title":"J Minim Invasive Gynecol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2026.1853725","article-title":"Multidimensional assessment of urinary dysfunction and quality of life after cervical cancer treatment: a multicenter study integrating urodynamics and patient-reported outcomes","volume":"16","author":"Bereza","year":"2026","journal-title":"Front Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.866283","article-title":"Nomogram predicting lymph node metastasis in the early-stage cervical cancer","volume":"9","author":"Yang","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/s12885-023-10932-0","article-title":"Developing a nomogram for preoperative prediction of cervical cancer lymph node metastasis by multiplex immunofluorescence","volume":"23","author":"Wu","year":"2023","journal-title":"BMC Cancer"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.19.21819","article-title":"Cervical cancer: 2018 revised International Federation of Gynecology and Obstetrics staging system and the role of imaging","volume":"214","author":"Saleh","year":"2020","journal-title":"AJR Am J Roentgenol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.08.020","article-title":"British Gynaecological Cancer Society (BGCS) cervical cancer guidelines: Recommendations for practice","volume":"256","author":"Reed","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22570","article-title":"Bladder function after radical hysterectomy for cervical cancer","volume":"34","author":"Laterza","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/03913988241262593","article-title":"Study on the recovery of bladder function in patients with cervical cancer after operation by portable ultrasound combined","volume":"47","author":"Zhao","year":"2024","journal-title":"Int J Artif Organs"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.40.10.9271","article-title":"Application and clinical efficacy of comprehensive nursing intervention in pelvic floor and bladder function recovery post-cervical cancer surgery","volume":"40","author":"Zhao","year":"2024","journal-title":"Pak J Med Sci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02632-7","article-title":"Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical cancer","volume":"23","author":"Baessler","year":"2021","journal-title":"Clin Transl Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2025.02.023","article-title":"Evaluation of physical function and quality of life before and after nonradical surgical therapy for stage IA1 and IA2-IB1 cervical cancer (GOG-0278)","volume":"195","author":"Carter","year":"2025","journal-title":"Gynecol Oncol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.56434\/j.arch.esp.urol.20257805.78","article-title":"The impact of early postoperative pelvic floor muscle exercise on urinary retention and urodynamics after radical hysterectomy for cervical cancer","volume":"78","author":"Zhang","year":"2025","journal-title":"Arch Esp Urol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00345-025-05549-w","article-title":"Comparison of extended and standard lymph node dissection in radical cystectomy for urothelial bladder cancer: a systematic review and meta-analysis","volume":"43","author":"\u015alusarczyk","year":"2025","journal-title":"World J Urol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/11795549221127161","article-title":"Effect of number of retrieved lymph nodes on prognosis in FIGO stage IA1-IIA2 cervical cancer patients treated with primary radical surgery","volume":"16","author":"Jiang","year":"2022","journal-title":"Clin Med Insights Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15371","article-title":"Postsurgical urodynamic study of total laparoscopic nerve-sparing radical hysterectomy for uterine cervical cancer","volume":"48","author":"Terada","year":"2022","journal-title":"J Obstet Gynaecol Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.38.3.4495","article-title":"Effect of Kegel pelvic floor muscle exercise combined with clean intermittent self-catheterization on urinary retention after radical hysterectomy for cervical cancer","volume":"38","author":"Zong","year":"2022","journal-title":"Pak J Med Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2308900","article-title":"Simple versus radical hysterectomy in women with low-risk cervical cancer","volume":"390","author":"Plante","year":"2024","journal-title":"N Engl J Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.02335","article-title":"LACC trial: Final analysis on overall survival comparing open versus minimally invasive radical hysterectomy for early-stage cervical cancer","volume":"42","author":"Ramirez","year":"2024","journal-title":"J Clin Oncol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2019.1683658","article-title":"Use of vaginal reconstructive surgery in cervical cancer patients to prevent vaginal stump contracture","volume":"34","author":"Wang","year":"2019","journal-title":"J Invest Surg"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2174\/1574893617666220524123825","article-title":"The immune-based prognostic score for the immunogenomic landscape aanalysis and application of chemotherapy in breast cancer","volume":"17","author":"Lu","year":"2022","journal-title":"Curr Bioinf"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2174\/0115748936298012240322091111","article-title":"Integrated somatic mutation network diffusion model for stratification of breast cancer into different metabolic mutation subtypes","volume":"20","author":"Su","year":"2025","journal-title":"Curr Bioinf"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2174\/0115748936380191250710051557","article-title":"Integrated metabolic-related transcription factor protein activity for stratification of breast cancer with distinct clinical outcomes","volume":"21","author":"Xiong","year":"2026","journal-title":"Curr Bioinf"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2174\/0115748936288453240124082031","article-title":"Integrated machine learning algorithms for stratification of patients with bladder cancer","volume":"19","author":"He","year":"2024","journal-title":"Curr Bioinf"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1877348\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:33:04Z","timestamp":1789705984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1877348\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":26,"alternative-id":["10.3389\/fonc.2026.1877348"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1877348","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"article-number":"1877348"}}