{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:12:31Z","timestamp":1788527551803,"version":"build-2803163510"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021267","name":"Breast Cancer Trials","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021267","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer. It accounts for up to 15% of all breast cancer diagnoses, and there is an increasing population of people living with a diagnosis of \u2018lobular\u2019. ILC has historically been understudied and is underrepresented in clinical trials. Presenting with pathology features typical of a good prognosis (oestrogen receptor-positive, HER2-negative, grade 2), a diagnosis of ILC can be framed as one with a \u2018good outcome\u2019. But whether the data support this over time remains to be seen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present a comprehensive narrative review to ascertain whether ILC has a better outcome than invasive carcinoma of no special type (IC-NST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A number of the research studies analysed showed that ILC can have a better outcome at 5 years and still have a poorer outcome over time, whilst others showed that IC-NST has a poor outcome early, which is maintained over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We discuss limitations and confounders and, critically, give voice to the people living with a lobular breast cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1877790","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:14:46Z","timestamp":1788524086000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lobular breast cancer and prognosis: what should we tell patients?"],"prefix":"10.3389","volume":"16","author":[{"given":"Tivya","family":"Kulasegaran","sequence":"first","affiliation":[{"name":"Fraser Institute, Faculty of Health, Medicine and Behavioural Science, The University of Queensland","place":["Brisbane, QLD, Australia"]},{"name":"Cancer Care Services, Metro North Hospital and Health Service","place":["Brisbane, QLD, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Beecher","sequence":"additional","affiliation":[{"name":"Fraser Institute, Faculty of Health, Medicine and Behavioural 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