{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:59:48Z","timestamp":1782892788481,"version":"3.54.5"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and an increased risk of progression to acute myeloid leukemia (AML). Patients with MDS often develop progressive systemic iron overload due to ineffective erythropoiesis, dysregulated hepcidin expression, and repeated blood transfusions. Excess free iron promotes reactive oxygen species generation through the Fenton reaction, resulting in persistent oxidative stress within the bone marrow microenvironment. These abnormalities are closely associated with ineffective hematopoiesis. Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. In MDS, ferroptosis appears to play a dual role. In lower-risk disease settings characterized by ineffective erythropoiesis and anemia, ferroptosis-related injury in erythroid-lineage cells may exacerbate ineffective erythropoiesis. In contrast, in higher-risk or clonally progressive disease settings, selective induction of ferroptosis in malignant clonal cells may represent a potential therapeutic strategy. However, current ferroptosis-targeting agents still face several limitations, including poor water solubility, low stability\n                    <jats:italic>in vivo<\/jats:italic>\n                    , insufficient bone marrow targeting, and possible toxicity to normal tissues. Nanotechnology may offer a promising approach to address these challenges. Nanocarriers can improve bone marrow targeting through surface modification and optimized physicochemical properties, while also enabling controlled drug release and co-delivery of multiple therapeutic agents to enhance efficacy and reduce side effects. This review summarizes the role of ferroptosis in the pathogenesis and treatment of MDS, discusses the major challenges in current ferroptosis-based therapies, and highlights the opportunities and challenges of nanotechnology-mediated ferroptosis regulation as a potential future strategy for precision treatment of MDS.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1887533","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:07:15Z","timestamp":1782886035000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role and therapeutic potential of nanotechnology-mediated ferroptosis regulation in myelodysplastic syndromes"],"prefix":"10.3389","volume":"16","author":[{"given":"Wanhua","family":"An","sequence":"first","affiliation":[{"name":"School of Medicine, Lincoln University College","place":["Petaling Jaya, Malaysia"]},{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farra Aidah","family":"Jumuddin","sequence":"additional","affiliation":[{"name":"School of Medicine, Lincoln University College","place":["Petaling Jaya, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-518886","article-title":"Clinical and biological implications of driver mutations in myelodysplastic syndromes","volume":"122","author":"Papaemmanuil","year":"2013","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised international prognostic scoring system (IPSS-R) for myelodysplastic syndromes","volume":"54","author":"Miyazaki","year":"2013","journal-title":"Rinsho Ketsueki"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000277","article-title":"Lower risk but high risk","volume":"2021","author":"DeZern","year":"2021","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised international prognostic scoring system for myelodysplastic syndromes","volume":"120","author":"Greenberg","year":"2012","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70350","article-title":"Loss of FTH1 induces ferritinophagy-mediated ferroptosis in anaemia of myelodysplastic syndromes","volume":"29","author":"Yang","year":"2025","journal-title":"J Cell Mol Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(09)70003-8","article-title":"Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study","volume":"10","author":"Fenaux","year":"2009","journal-title":"Lancet Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.01.7038","article-title":"Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making","volume":"23","author":"Malcovati","year":"2005","journal-title":"J Clin Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v112.11.640.640","article-title":"Independent impact of iron overload and transfusion dependency on survival and leukemic evolution in patients with myelodysplastic syndrome","volume":"112","author":"Sanz","year":"2008","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563221","article-title":"Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome","volume":"124","author":"Shenoy","year":"2014","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/medicines6030085","article-title":"A short review of iron metabolism and pathophysiology of iron disorders","volume":"6","author":"Yiannikourides","year":"2019","journal-title":"Medicines"},{"key":"B11","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J Res Med Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00139","article-title":"Mechanisms of ferroptosis and relations with regulated cell death: a review","volume":"10","author":"Lei","year":"2019","journal-title":"Front Physiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"2022","journal-title":"Ann Trans Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"9156","DOI":"10.1038\/s41598-020-66162-y","article-title":"Iron overload alters the energy metabolism in patients with myelodysplastic syndromes: results from the multicenter FISM BIOFER study","volume":"10","author":"Cilloni","year":"2020","journal-title":"Sci Rep"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05946-y","article-title":"Increased ferroptosis of erythrocytes is associated with myelodysplastic syndromes","volume":"103","author":"Zhang","year":"2024","journal-title":"Ann Hematol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40164-025-00664-1","article-title":"A correlation of ineffective erythropoiesis and dysregulated signaling pathways in myelodysplastic syndromes\/neoplasms","volume":"14","author":"Wu","year":"2025","journal-title":"Exp Hematol Oncol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01656","article-title":"Abnormal ferroptosis in myelodysplastic syndrome","volume":"10","author":"Lv","year":"2020","journal-title":"Front Oncol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/10815589241246541","article-title":"A new therapeutic perspective: Erastin inhibits tumor progression by driving ferroptosis in myelodysplastic syndromes","volume":"72","author":"Li","year":"2024","journal-title":"J Investig Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"7661","DOI":"10.3390\/ijms24087661","article-title":"Ferroptosis in haematological Malignancies and associated therapeutic nanotechnologies","volume":"24","author":"Mynott","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403036","article-title":"Engineered nanoparticles for drug delivery in cancer therapy","volume":"53","author":"Sun","year":"2014","journal-title":"Angew Chem Int Ed Engl"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging-US"},{"key":"B24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a P53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7554\/elife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41419-024-06866-5","article-title":"RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB\/Bcl-2 signaling pathway","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103367","article-title":"Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae","volume":"163","author":"Kim","year":"2021","journal-title":"Crit Rev Oncol Hematol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2025.110606","article-title":"Benzene induces myelodysplasia and hematotoxicity via ferroptosis induction and downregulation of GPX4","volume":"773","author":"Bao","year":"2025","journal-title":"Arch Biochem Biophys"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1221","article-title":"Construction and experimental validation of a novel ferroptosis-related gene signature for myelodysplastic syndromes","volume":"12","author":"Zhu","year":"2024","journal-title":"Immun Inflammation Dis"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2023.2288475","article-title":"Diagnostic and prognostic value of ferroptosis-related genes in patients with myelodysplastic neoplasms","volume":"28","author":"Chen","year":"2023","journal-title":"Hematology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2127462","article-title":"Expression and clinical significance of RAG1 in myelodysplastic syndromes","volume":"27","author":"Huang","year":"2022","journal-title":"Hematology"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm9427","article-title":"Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction","volume":"8","author":"Fujihara","year":"2022","journal-title":"Sci Adv"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.70164","article-title":"Long-term follow-up and combined phase 2 results of eprenetapopt and azacitidine in patients with TP53 mutant MDS\/AML","volume":"9","author":"Sallman","year":"2025","journal-title":"Hemasphere"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113363","article-title":"Iron chelator deferasirox inhibits NF-\u03baB activity in hepatoma cells and changes sorafenib-induced programmed cell deaths","volume":"153","author":"Jomen","year":"2022","journal-title":"BioMed Pharmacother"},{"key":"B37","article-title":"Transcriptomics and metabolomics analysis to explore the ferroptosis susceptibility of venetoclax-resistant AML cells","volume":"33","author":"Li","year":"2025","journal-title":"J Exp Hematol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-025-3237-4","article-title":"SREBP1-activated lipid metabolism drives ferroptosis and progression of clear cell renal cell carcinoma","volume":"69","author":"Wang","year":"2026","journal-title":"Sci China Life Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202016872","article-title":"NIR-actuated remote activation of ferroptosis in target tumor cells through a photothermally responsive iron-chelated biopolymer nanoplatform","volume":"60","author":"Xue","year":"2021","journal-title":"Angew Chem Int Ed Engl"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101965","article-title":"As4S4 nanoparticles promote effective terminal erythropoiesis in bone marrow mononuclear cells from patients with myelodysplastic syndromes","volume":"52","author":"Wang","year":"2023","journal-title":"Nano Today"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107331","article-title":"Ferroptosis inducers: a new frontier in cancer therapy","volume":"146","author":"Ma","year":"2024","journal-title":"Bioorg Chem"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202307273","article-title":"Co\u2010delivery of siNRF2 and sorafenib by a \u201cClick\u201d dual functioned hyperbranched nanocarrier for synergistically inducing ferroptosis in hepatocellular carcinoma","volume":"20","author":"Tong","year":"2023","journal-title":"Small"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00892","article-title":"Engineering magnetosomes for ferroptosis\/immunomodulation synergism in cancer","volume":"13","author":"Zhang","year":"2019","journal-title":"ACS Nano"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35568","article-title":"RNA nanotechnology-mediated cancer immunotherapy","volume":"10","author":"Lin","year":"2020","journal-title":"Theranostics"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202519473","article-title":"Optimized lipid nanoparticles for co-delivery of mRNA and siRNA therapeutics in refractory liver cancer","volume":"38","author":"Liao","year":"2026","journal-title":"Adv Mater"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30901","article-title":"The application of Fe3O4 nanoparticles in cancer research: a new strategy to inhibit drug resistance","volume":"80","author":"Wang","year":"2007","journal-title":"J BioMed Mater Res A"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S24078","article-title":"Effect of magnetic Fe3O4 nanoparticles with 2-methoxyestradiol on the cell-cycle progression and apoptosis of myelodysplastic syndrome cells","volume":"6","author":"Xia","year":"2011","journal-title":"Int J Nanomed"},{"key":"B48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jconrel.2017.10.012","article-title":"Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity","volume":"268","author":"Wu","year":"2017","journal-title":"J Ctrl Release"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2025.127328","article-title":"Toxic mechanisms of nanoparticle-induced ferroptosis and current research challenges: a critical review","volume":"387","author":"Yang","year":"2025","journal-title":"Environ pollut"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2396568","article-title":"Therapeutic types and advantages of functionalized nanoparticles in inducing ferroptosis in cancer therapy","volume":"56","author":"Wang","year":"2024","journal-title":"Ann Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat Nanotec"},{"key":"B52","doi-asserted-by":"publisher","first-page":"399","DOI":"10.22541\/au.175424414.42580900\/v1","article-title":"A degradable multi-metal-chelating stealth nanoplatform for dual ferroptosis\/cuproptosis-enhanced metalloimmunotherapy in leukemia","volume":"24","author":"Wang","year":"2026","journal-title":"J Nanobiotech"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwac167","article-title":"Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer","volume":"10","author":"Liu","year":"2023","journal-title":"Natl Sci Rev"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704007","article-title":"Emerging strategies of cancer therapy based on ferroptosis","volume":"30","author":"Shen","year":"2018","journal-title":"Adv Mater"},{"key":"B55","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s40001-024-01822-7","article-title":"Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology","volume":"29","author":"Ashoub","year":"2024","journal-title":"Eur J Med Res"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J Exp Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s12672-025-01911-x","article-title":"Advances in understanding ferroptosis mechanisms and their impact on immune cell regulation and tumour immunotherapy","volume":"16","author":"Zhu","year":"2025","journal-title":"Discov Oncol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41419-025-08204-9","article-title":"Immune cells dying from ferroptosis: mechanisms and therapeutic opportunities","volume":"16","author":"Liu","year":"2025","journal-title":"Cell Death Dis"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.cd-19-0338","article-title":"Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11","volume":"9","author":"Lang","year":"2019","journal-title":"Cancer Discov"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1016\/j.celrep.2019.10.070","article-title":"B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis","volume":"29","author":"Muri","year":"2019","journal-title":"Cell Rep"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03723-1","article-title":"Inhalable targeted CD8\u2009+\u2009T cell nanoparticles loaded ferroptosis inhibitor ferrostatin-1 alleviate acute lung injury","volume":"23","author":"Ma","year":"2025","journal-title":"J Nanobiotech"},{"key":"B62","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10495-025-02247-1","article-title":"Macrophage ferroptosis in hematologic Malignancies: emerging mechanisms and therapeutic implications","volume":"31","author":"Zhou","year":"2026","journal-title":"Apoptosis"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-822619","article-title":"Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion","volume":"131","author":"Youssef","year":"2018","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.nantod.2015.06.006","article-title":"Nanoparticle uptake: the phagocyte problem","volume":"10","author":"Gustafson","year":"2015","journal-title":"Nano Today"},{"key":"B65","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12951-025-03271-8","article-title":"Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque","volume":"23","author":"Chen","year":"2025","journal-title":"J Nanobiotech"},{"key":"B66","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12951-022-01360-6","article-title":"Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM","volume":"20","author":"Liu","year":"2022","journal-title":"J Nanobiotech"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.025","article-title":"ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis","volume":"161","author":"Cubillos-Ruiz","year":"2015","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307870","article-title":"Enhanced photodynamic therapy synergizing with inhibition of tumor neutrophil ferroptosis boosts anti-PD-1 therapy of gastric cancer","volume":"11","author":"Zhu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.cmet.2023.09.004","article-title":"Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1","volume":"35","author":"Zhao","year":"2023","journal-title":"Cell Metab"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c07973","article-title":"Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery","volume":"15","author":"Feng","year":"2021","journal-title":"ACS Nano"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1049\/nbt2.12137","article-title":"Neutrophil membrane biomimetic delivery system (Ptdser-NM-Lipo\/Fer-1) designed for targeting atherosclerosis therapy","volume":"17","author":"Li","year":"2023","journal-title":"IET Nanobiotech"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-134625","article-title":"A phase 1 study of NKX101, an allogeneic CAR natural killer (NK) cell therapy, in subjects with relapsed\/refractory (R\/R) acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (MDS)","volume":"136","author":"Bachier","year":"2020","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-026-02697-3","article-title":"Interplay between natural killer cells and ferroptosis: novel insights in tumor immunity and therapeutic potential","volume":"24","author":"Sun","year":"2026","journal-title":"Cell Commun Signal"},{"key":"B74","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13046-023-02629-w","article-title":"L-kynurenine induces NK cell loss in gastric cancer microenvironment via promoting ferroptosis","volume":"42","author":"Cui","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.cmet.2021.03.023","article-title":"Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment","volume":"33","author":"Poznanski","year":"2021","journal-title":"Cell Metab"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-026-04550-8","article-title":"NK cell vesicles-based nanoplatform loaded with sorafenib synergizing ferroptosis and antitumor immunity against hepatocellular carcinoma","author":"Gong","year":"2026","journal-title":"J Nanobiotech"},{"key":"B77","doi-asserted-by":"publisher","first-page":"5656","DOI":"10.3390\/cancers14225656","article-title":"Bone marrow immune microenvironment in myelodysplastic syndromes","volume":"14","author":"Kouroukli","year":"2022","journal-title":"Cancers (Basel)"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1887533\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:07:17Z","timestamp":1782886037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1887533\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":77,"alternative-id":["10.3389\/fonc.2026.1887533"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1887533","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"1887533"}}