{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:47:32Z","timestamp":1785822452170,"version":"3.56.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Extramedullary involvement of the urinary bladder by plasma cell myeloma is extremely rare. This report presents a case to explore the clinical application value of contrast-enhanced ultrasound (CEUS) in the diagnosis and therapeutic monitoring of this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 54-year-old man with high-risk multiple myeloma (IgA\u03bb type, R-ISS stage II, 1q21 amplification) developed newly-onset urinary frequency during systemic therapy. Grayscale ultrasound, color Doppler ultrasound, and CEUS were performed, followed by CEUS-guided percutaneous biopsy. After pathological confirmation, salvage therapy was administered, and follow-up CEUS was performed to evaluate treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Grayscale ultrasound showed diffuse thickening of the bladder wall (maximum thickness approximately 2.5\u00a0cm) with abundant color Doppler flow signals. CEUS observed a perfusion pattern of \u201crapid arterial uptake, slow washout, and hyperenhancement\u201d: the muscular layer demonstrated early enhancement at 11 seconds with centrifugal (serosal-to-mucosal) filling, and marked contrast agent retention was observed during the venous phase. CEUS-guided biopsy and subsequent immunohistochemistry confirmed monoclonal plasma cell myeloma infiltration of the bladder (strongly positive for CD38, kappa-negative, lambda-positive). Follow-up CEUS after salvage therapy demonstrated a reduction in bladder wall thickness to 0.72\u00a0cm with delayed arterial enhancement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CEUS-guided transabdominal biopsy targeting the muscular layer may be considered in patients with suspected bladder plasmacytoma and high-risk features for transurethral resection to avoid false negatives from mucosal sampling. Furthermore, CEUS provides a nephrotoxicity-free modality for monitoring treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1892543","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:39:22Z","timestamp":1785821962000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast-enhanced ultrasound-guided biopsy and perfusion monitoring for bladder involvement in relapsed multiple myeloma: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Yanyan","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820701)50:1<146::aid-cncr2820500127>3.0.co;2-x","article-title":"Extramedullary plasmacytoma of the bladder: a case report and review of literature","volume":"50","author":"Yang","year":"1982","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s1078-1439(03)00076-0","article-title":"Extramedullary plasmacytoma invading the bladder: case report and review of the literature","volume":"21","author":"L\u00f3pez","year":"2003","journal-title":"Urol Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)35519-2","article-title":"Extramedullary plasmacytoma of the bladder: case report and review of the literature","volume":"150","author":"Ho","year":"1993","journal-title":"J Urol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2147\/OAJU.S10897","article-title":"Bladder extramedullary plasmacytoma and synchronous bladder urothelial transitional cell carcinoma: a case report and review of the literature","volume":"3","author":"Wadhwa","year":"2011","journal-title":"Open Access J Urol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2006.02.005","article-title":"Radiologic diagnosis and staging of renal and bladder cancer","volume":"41","author":"Ng","year":"2006","journal-title":"Semin Roentgenol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1047948","article-title":"Contrast-enhanced ultrasound in the bladder: critical features to differentiate occupied lesions","volume":"2021","author":"Liu","year":"2021","journal-title":"Comput Math Methods Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.232815","article-title":"Development and validation of a contrast-enhanced US VI-RADS for evaluating muscle invasion in bladder cancer","volume":"312","author":"Han","year":"2024","journal-title":"Radiology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2025.0086","article-title":"Contrast-enhanced ultrasound in the diagnosis of neoplastic lesions of the urinary bladder","volume":"78","author":"Kufel","year":"2025","journal-title":"Cent Eur J Urol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70106","article-title":"Contrast-enhanced ultrasound enables precision diagnosis of preoperative muscle invasion in bladder cancer: a prospective study","volume":"6","author":"Ou","year":"2025","journal-title":"MedComm (2020)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.02.002","article-title":"Plasma cell neoplasms of the bladder: a series of 9 cases","volume":"111","author":"Gupta","year":"2021","journal-title":"Hum Pathol"},{"key":"B11","article-title":"Solitary extramedullary plasmacytoma of the bladder: a case report and literature","volume":"24","author":"Khaliq","year":"2010","journal-title":"Oncol (Williston Park)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14291","article-title":"Progression of a solitary plasmacytoma to multiple myeloma. A population-based registry of the northern Netherlands","volume":"175","author":"de Waal","year":"2016","journal-title":"Br J Haematol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(23)00223-1","article-title":"Management of multiple myeloma-related renal impairment: recommendations from the International Myeloma Working Group","volume":"24","author":"Dimopoulos","year":"2023","journal-title":"Lancet Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i25.7453","article-title":"Successful treatment of solitary bladder plasmacytoma: a case report","volume":"9","author":"Cao","year":"2021","journal-title":"World J Clin cases"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1892543\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:39:23Z","timestamp":1785821963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1892543\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":14,"alternative-id":["10.3389\/fonc.2026.1892543"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1892543","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"article-number":"1892543"}}