{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:25:32Z","timestamp":1787030732394,"version":"build-2736575974"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Castleman disease (CD) comprises a heterogeneous group of lymphoproliferative disorders. Unicentric CD (UCD) involving the adrenal region is uncommon and poses diagnostic challenges because it can resemble adrenal neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 37-year-old female presented with a 10-year history of intermittent hyperhidrosis and facial flushing, and a one-month history of right chest and abdominal pain. Imaging revealed a 53\u00a0mm \u00d7 42\u00a0mm heterogeneous mass in the left adrenal region with calcification and marked enhancement. Endocrine evaluation showed no hormonal hypersecretion. The patient underwent laparoscopic tumor resection. Histopathology and immunohistochemistry confirmed plasma cell type UCD, with HHV-8 negative on both serology and immunohistochemistry. Postoperative recovery was uneventful. Postoperative PET\/CT and PET\/MRI showed no evidence of residual or recurrent disease. At the two-year follow-up, the patient remained asymptomatic with no evidence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adrenal-region UCD is an uncommon entity that can mimic nonfunctional adrenal tumors. Complete surgical excision is curative. This case highlights the importance of including UCD in the differential diagnosis of well-defined adrenal masses without endocrine abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1893723","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:59Z","timestamp":1787027279000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unicentric Castleman disease of plasma cell type in the adrenal region: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Wei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Urology, Liwan Central Hospital of Guangzhou","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology, Liwan Central Hospital of Guangzhou","place":["Guangzhou, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jin","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Urology, Liwan Central Hospital of Guangzhou","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003334","article-title":"International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease","volume":"4","author":"van Rhee","year":"2020","journal-title":"Blood Adv"},{"key":"B2","unstructured":"Characterizing the heterogeneity of Castleman disease and oligocentric subtype: findings from the 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