{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:06:45Z","timestamp":1784696805395,"version":"3.55.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Congenital intracranial-extracranial communicating mixed germ cell tumors (MGCTs) are extremely rare in infants, with no standardized treatment protocol. We report a 2-month-old female infant with giant congenital intracranial-extracranial communicating MGCT accompanied by typical \u201ccrater-like\u201d skull defect. Preoperative serum alpha-fetoprotein (AFP) was significantly elevated, while \u03b2-human chorionic gonadotropin (\u03b2-HCG) was within normal range. Maximal safe resection was performed, and pathology confirmed mixed germ cell tumor (immature teratoma WHO grade 3 + yolk sac tumor). Next-generation sequencing identified a novel ARID1B c.1628C&amp;gt;G (p.A543G) somatic mutation, previously unreported in pediatric intracranial MGCTs. Postoperative imaging confirmed subtotal resection with continuous AFP decline. No tumor recurrence was observed during 3-month follow-up. This case expands the genomic mutation spectrum of pediatric intracranial MGCTs and supports maximal safe resection as first-line treatment for this rare infantile tumor.<\/jats:p>","DOI":"10.3389\/fonc.2026.1895357","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:39:44Z","timestamp":1784695184000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Infantile giant intracranial-extracranial communicating mixed germ cell tumor with ARID1B gene mutation: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Yifeng","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurosurgery, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital, Sichuan University, Wuhou District","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s12672-024-01673-y","article-title":"A rare case of huge intracranial yolk sac tumor 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