{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:15:06Z","timestamp":1783574106678,"version":"3.55.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Colonic schwannoma is a rare gastrointestinal mesenchymal tumor that is usually benign but may be difficult to distinguish from malignancy before surgery. This case is notable because a benign colonic schwannoma showed both pronounced restricted diffusion on MRI and prominent mesocolic lymphadenopathy, creating a strong radiologic impression of malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 43-year-old woman presented with a 2-day history of abdominal pain accompanied by altered bowel habits. Colonoscopy revealed a large spherical submucosal mass in the transverse colon. Biopsy suggested a neurogenic tumor favoring schwannoma, but malignancy could not be excluded because of limited sampling. Contrast-enhanced CT showed a large colonic mass with heterogeneous internal density, focal cystic change, irregular serosal appearance, and multiple enlarged mesocolic lymph nodes. MRI demonstrated marked restricted diffusion, with hyperintensity on diffusion-weighted imaging and hypointensity on ADC maps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis, interventions, and outcomes<\/jats:title>\n                    <jats:p>The lesion was clinically suspected to be a malignant colonic tumor. The patient underwent laparoscopic adhesiolysis and left hemicolectomy. Postoperative histopathology unexpectedly confirmed a benign gastrointestinal schwannoma. All 34 harvested mesocolic lymph nodes showed reactive hyperplasia without metastasis. The patient recovered after surgery and was discharged following supportive treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Benign colonic schwannoma can closely mimic malignancy when restricted diffusion and prominent regional lymphadenopathy are present. This single case underscores that such features are not specific for malignancy; because imaging and biopsy could not exclude a malignant tumor, oncologic resection remained appropriate, and the definitive diagnosis still depended on histopathology and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1895724","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:21:15Z","timestamp":1783570875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Benign colonic schwannoma with restricted diffusion mimicking malignancy"],"prefix":"10.3389","volume":"16","author":[{"given":"Hao","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiology, The Third Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, 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