{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:04:29Z","timestamp":1789362269864,"version":"build-2803163510"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the pathogenic characteristics of colorectal polyps and the influence of metabolic factors among individuals aged 18 to 39 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on the clinical and pathological data of 2,149 young adults who underwent colonoscopy, and a comparative analysis was conducted by age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The adenoma detection rate increased significantly with age (4.58% \u2192 13.23%,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u00a00.01), while the detection rate of serrated polyps remained stable between 7.44% and 12.89%. The detection rate of advanced neoplasia also showed an upward trend (1.26% \u2192 3.26%). The detection rate of advanced neoplasia in men aged 35 to 39 years reached 4.89%, which was 3.4 times that of women in the same age group. No statistically significant difference was observed in the clinical characteristics between adenomas and serrated polyps. However, for serrated polyps, each 1 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      increase in BMI was associated with a 13% increase in the risk of left colon lesions (OR\u00a0=\u00a01.13,\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.036), and this association was not observed in adenomas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Men aged 35 to 39 years constitute a high-risk subgroup for advanced colorectal neoplasia. The effect of metabolic factors on the location of colorectal polyps exhibits pathological type heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1897209","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:32:57Z","timestamp":1789360377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-stratified prevalence of colorectal adenoma and advanced neoplasia in adults aged 18\u201339 years: a single-center cross-sectional study of 2, 149 colonoscopies"],"prefix":"10.3389","volume":"16","author":[{"given":"Yiming","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Peking University International Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking 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