{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:14:51Z","timestamp":1783401291042,"version":"3.54.6"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Extramedullary plasmacytoma (EMP) is a rare plasma cell malignancy, accounting for approximately 3% of all plasma cell neoplasms. Gastric plasmacytoma, a distinct subtype of EMP arising from B lymphocytes, is extremely uncommon, representing roughly 2% of EMP cases, and lacks specific clinical manifestations. Herein, we report a 53-year-old male presenting with persistent acid reflux and heartburn. Gastroscopy identified a flat, elevated lesion in the gastric body. Endoscopic mucosal resection (EMR) was performed to obtain the lesion specimen. The diagnosis of primary solitary gastric plasmacytoma was confirmed via histopathology, immunohistochemistry, bone marrow aspiration, serum and urine free light chain assays, and positron emission tomography\u2013computed tomography (PET-CT). We further review the clinical features, diagnostic approaches, therapeutic strategies, and prognosis of this disease, aiming to provide a reference for the diagnosis and management of rare gastric plasma cell tumors in clinical practice.<\/jats:p>","DOI":"10.3389\/fonc.2026.1899646","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:23:31Z","timestamp":1783398211000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case of incidentally discovered isolated gastric plasmacytoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Ya-nan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of High Altitude Medicine, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"Department of Thoracic Surgery, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"First Clinical College, Gansu University of Traditional Chinese Medicine","place":["Lanzhou, Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"Department of Thoracic Surgery, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-chong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"Department of Thoracic Surgery, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-tai","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"Department of Thoracic Surgery, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"First Clinical College, Gansu University of Traditional Chinese Medicine","place":["Lanzhou, Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"Department of Thoracic Surgery, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"First Clinical College, Gansu University of Traditional Chinese Medicine","place":["Lanzhou, Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-chen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]},{"name":"Department of Thoracic Surgery, 940th Hospital of Joint Logistics Support Force, Chinese People\u2019s Liberation Army","place":["Lanzhou, Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0004","article-title":"Multiple myeloma, version 1.2013","volume":"11","author":"Anderson","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03431-3","article-title":"Plasma cell neoplasms and related entities-evolution in diagnosis and classification","volume":"482","author":"Fend","year":"2023","journal-title":"Virchows Arch"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.162","article-title":"Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases","volume":"75","author":"Susnerwala","year":"1997","journal-title":"Br J Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320950587","article-title":"Extramedullary plasmacytoma: long-term clinical outcomes in a single-center in China and literature review","volume":"100","author":"Zhu","year":"2021","journal-title":"Ear Nose Throat J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4816","article-title":"Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts","volume":"85","author":"Alexiou","year":"1999","journal-title":"Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1157\/13117905","article-title":"Gastric plasmacytoma as an uncommon cause of upper gastrointestinal bleeding","volume":"31","author":"Vicu\u00f1a Arregui","year":"2008","journal-title":"Gastroenterol Hepatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1018190","article-title":"Gastric involvement with excavated plasmacytoma: case report and review of endoscopic criteria","volume":"20","author":"Sloyer","year":"1988","journal-title":"Endoscopy"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12005","article-title":"Gastric solitary plasmacytoma associated with +Helicobacter pylori infection","volume":"29","author":"Gonzalez Cueto","year":"1999","journal-title":"Acta Gastroenterol Latinoam"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0549-1","article-title":"Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel","volume":"11","author":"Caers","year":"2018","journal-title":"J Hematol Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12005","article-title":"Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics","volume":"93","author":"Bink","year":"2008","journal-title":"Haematologica"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-566521","article-title":"Outcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light-chain analysis","volume":"124","author":"Hill","year":"2014","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00259-017-3810-5","article-title":"18F-FDG PET\/CT in solitary plasmacytoma: metabolic behavior and progression to multiple myeloma","volume":"45","author":"Albano","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"B13","doi-asserted-by":"publisher","first-page":"S1063","DOI":"10.14309\/01.ajg.0000783600.83340.92","article-title":"S2517\u2003Primary gastric plasmacytoma cured with endoscopic full-thickness resection","volume":"116","author":"St. Laurent","year":"2021","journal-title":"Off J Am Coll Gastroenterol | ACG"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.21873\/cdp.10350","article-title":"Radiotherapy for solitary bony or extramedullary plasmacytoma","volume":"4","author":"Katano","year":"2024","journal-title":"Cancer Diagn Progn"},{"key":"B15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13014-019-1265-5","article-title":"Impact of radiation dose on local control and survival in extramedullary head and neck plasmacytoma","volume":"14","author":"Oertel","year":"2019","journal-title":"Radiat Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26031","article-title":"Solitary plasmacytomas: outcome and prognostic factors after definitive radiation therapy","volume":"117","author":"Reed","year":"2011","journal-title":"Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.08.041","article-title":"Successful treatment of primary advanced gastric plasmacytoma using a combination of surgical resection and chemotherapy with bortezomib: a case report","volume":"27","author":"Fukuhara","year":"2016","journal-title":"Int J Surg Case Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-30","article-title":"Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma","volume":"8","author":"Kanzawa","year":"2013","journal-title":"Diagn Pathol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.19.8341","article-title":"Primary gastric plasmacytoma and Helicobacter pylori infection","volume":"27","author":"Stasi","year":"2009","journal-title":"J Clin Oncol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/s0194-5998(98)70021-x","article-title":"Plasmacytomas of the head and neck","volume":"119","author":"Miller","year":"1998","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1899646\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:23:32Z","timestamp":1783398212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1899646\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":20,"alternative-id":["10.3389\/fonc.2026.1899646"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1899646","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"article-number":"1899646"}}