{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:07:07Z","timestamp":1789103227794,"version":"build-2803163510"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Lung adenocarcinoma (LUAD) is a highly aggressive malignancy originating from the bronchial epithelium or glandular tissues and represents the most rapidly increasing subtype of lung cancer worldwide. Its high incidence and mortality rates contribute to an overall unfavorable prognosis. Therapeutic options for patients with advanced-stage LUAD remain limited, emphasizing the urgent importance of identifying reliable prognostic biomarkers and novel therapeutic targets. Silent information regulator 2 (SIRT2), a member of the mammalian sirtuin family, has been implicated in multiple cancer types; however, its functional relevance in LUAD has not yet been comprehensively defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from TCGA and GEO were employed to evaluate SIRT2 expression patterns in LUAD. Functional enrichment approaches were applied to infer the biological pathways potentially regulated by SIRT2. Molecular docking and Gene Set Cancer Analysis (GSCA) were used to examine how SIRT2 expression and drug sensitivity are related, and to identify potential small-molecule interactors. Key candidate targets and compounds were subsequently subjected to in silico docking validation. The bioinformatic predictions were further verified through in vitro functional assays and Western blotting using A549 LUAD cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SIRT2 expression was markedly downregulated in LUAD tissues, and low SIRT2 levels were closely associated with adverse clinical prognostic features, including pathological stage, gender and primary treatment response. Reduced SIRT2 expression correlated with poorer overall, progression-free, and disease-specific survival. Functional enrichment indicated that SIRT2 is involved in multiple core signaling pathways implicated in LUAD progression. Furthermore, SIRT2 expression was strongly associated with ferroptosis-related pathways and estimated immune cell infiltration. Experimental validation in A549 LUAD cells revealed that SIRT2 is linked to suppressed malignant cellular phenotypes and reduced expression of the ferroptosis suppressor GPX4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collectively, these findings support SIRT2 as a potential prognostic biomarker for LUAD. The molecular networks and pathways uncovered here advance our understanding of SIRT2 biology and lay a foundation for further research. Additional studies focusing on immune-related signatures correlated with SIRT2 may facilitate the development of novel immunotherapeutic approaches for LUAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1900448","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:32:10Z","timestamp":1789101130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT2 is associated with prognosis, ferroptosis susceptibility, and immune infiltration in lung adenocarcinoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Medical Affairs Department, The Second Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-sha","family":"Ren","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, The Second Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Bai","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, The Second Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Medical Center of PLA General Hospital, National Clinical Research Center for Geriatric Diseases","place":["Beijing, China"]},{"name":"Department of Pathology, Zunyi Hospital of Traditional Chinese Medicine","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, Guizhou Nursing Vocational College","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Medical Center of PLA General Hospital, National Clinical Research Center for Geriatric Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713302","article-title":"MiRNAs in lung adenocarcinoma: Role, diagnosis, prognosis, and therapy","volume":"24","author":"Song","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217025","article-title":"LKB1 inhibits telomerase activity resulting in cellular senescence through histone lactylation in lung adenocarcinoma","volume":"595","author":"Liu","year":"2024","journal-title":"Cancer Lett"},{"key":"B3","doi-asserted-by":"publisher","first-page":"CD11044","DOI":"10.1002\/14651858.CD011044.pub3","article-title":"Chemotherapy and radiotherapy for advanced pancreatic cancer","volume":"12","author":"Haggstrom","year":"2024","journal-title":"Cochrane Database Systematic Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5603\/rpor.103136","article-title":"Prehabilitation approaches for gastrointestinal cancer surgery: A narrative review","volume":"29","author":"Girnyi","year":"2024","journal-title":"Rep Pract Oncol Radiotherapy J GreatPoland Cancer Center Poznan Polish Soc Radiat Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120677","article-title":"Comprehensive characterization of Rubus idaeus L. polysaccharides: Extraction, purification, structural diversity, biological efficacy, and structure-activity relationships","volume":"355","author":"Gao","year":"2026","journal-title":"J Ethnopharmacol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S466396","article-title":"Synergistic potential of nanomedicine in prostate cancer immunotherapy: Breakthroughs and prospects","volume":"19","author":"Jiang","year":"2024","journal-title":"Int J Nanomedicine"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.148082","article-title":"Polysaccharides of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm: Extraction, purification, structural characteristics, pharmacological activities, and structure-activity relationships: A review","volume":"330","author":"Gao","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"8375","DOI":"10.1038\/s41467-023-43732-y","article-title":"Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma","volume":"14","author":"Haga","year":"2023","journal-title":"Nat Commun"},{"key":"B9","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13046-023-02711-3","article-title":"B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma","volume":"42","author":"Cui","year":"2023","journal-title":"J Exp Clin Cancer Res Cr"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1727","article-title":"Genomic rearrangements define lineage relationships between adjacent lepidic and invasive components in lung adenocarcinoma","volume":"74","author":"Murphy","year":"2014","journal-title":"Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rxeng.2024.11.003","article-title":"Lung adenocarcinoma: Characteristic radiological presentations","volume":"66","author":"Robles G\u00f3mez","year":"2024","journal-title":"Radiologia"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1323344","article-title":"Progress in the treatment of lung adenocarcinoma by integrated traditional Chinese and Western medicine","volume":"10","author":"Jiang","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2018.11.009","article-title":"Spectrum of lung adenocarcinoma","volume":"40","author":"Hutchinson","year":"2019","journal-title":"Semin Ultrasound Ct Mr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1186\/s12967-025-06860-1","article-title":"Spatial features of tumor-infiltrating lymphocytes in primary lesions of lung adenocarcinoma predict lymph node metastasis","volume":"23","author":"Zhang","year":"2025","journal-title":"J Transl Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.120400","article-title":"Highly accurate diagnosis of lung adenocarcinoma and squamous cell carcinoma tissues by deep learning","volume":"265","author":"Qi","year":"2022","journal-title":"Spectrochimica Acta Part A Mol Biomolecular Spectrosc"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2024.10.005","article-title":"BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer","author":"Pun","year":"2024","journal-title":"Semin Cancer Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.107038","article-title":"Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy","volume":"143","author":"Kaya","year":"2024","journal-title":"Bioorg Chem"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/cells13232023","article-title":"SIRT2 inhibition by AGK2 promotes perinuclear cytoskeletal organisation and reduces invasiveness of MDA-MB-231 triple-negative breast cancer cells in confined in vitro models","volume":"13","author":"Jessop","year":"2024","journal-title":"Cells"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948183","article-title":"SIRT2-dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases","volume":"21","author":"Wang","year":"2020","journal-title":"EMBO Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202501552","article-title":"Fn14 controls the SIRT2-mediated deacetylation of Slug to inhibit the metastasis of epithelial ovarian cancer","volume":"12","author":"Wu","year":"2025","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2986444","article-title":"The oncogenic role and immune infiltration for CARM1 identified by pancancer analysis","volume":"2021","author":"Liu","year":"2021","journal-title":"J Oncol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2024.04.03","article-title":"SOX11 as a potential prognostic biomarker in hepatocellular carcinoma linked to immune infiltration and ferroptosis","volume":"36","author":"Chen","year":"2024","journal-title":"Chin J Cancer Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210068","article-title":"Construction of long noncoding RNA-associated ceRNA networks reveals potential biomarkers in Alzheimer's disease","volume":"82","author":"Ou","year":"2021","journal-title":"J Alzheimer's Dis Jad"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.682415","article-title":"Integrative analysis of neuregulin family members-related tumor microenvironment for predicting the prognosis in gliomas","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1478395","article-title":"SOX13 as a potential prognostic biomarker linked to immune infiltration and ferroptosis inhibits the proliferation, migration, and metastasis of thyroid cancer cells","volume":"15","author":"Ma","year":"2024","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.914060","article-title":"Comprehensive pan-cancer analysis of TRPM8 in tumor metabolism and immune escape","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty411","article-title":"GSCALite: A web server for gene set cancer analysis","volume":"34","author":"Liu","year":"2018","journal-title":"Bioinformatics"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133659","article-title":"Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs","volume":"275","author":"Zhang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2017.07.006","article-title":"Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease","volume":"8","author":"Vijayakumar","year":"2018","journal-title":"J Pharm Anal"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.601953","article-title":"Down regulation of SIRT2 reduced ASS induced NSCLC apoptosis through the release of autophagy components via exosomes","volume":"8","author":"Wang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S499771","article-title":"Prognostic role of SETDB2 in clear cell renal cell carcinoma: Linking immune infiltration, cuproptosis, and tumor suppression","volume":"17","author":"Lu","year":"2025","journal-title":"Cancer Manag Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41698-025-01097-z","article-title":"Pan cancer research reveals the role of PTGDS in tumor suppression and immune regulation","volume":"9","author":"Li","year":"2025","journal-title":"NPJ Precis Oncol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13027","article-title":"Clinicopathological significance of intelectin-1 in colorectal cancer: Intelectin-1 participates in tumor suppression and favorable progress","volume":"70","author":"Katsuya","year":"2020","journal-title":"Pathol Int"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102035","article-title":"Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases","volume":"91","author":"Wang","year":"2023","journal-title":"Ageing Res Rev"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914614","article-title":"Regulation of ferroptosis in lung adenocarcinoma","volume":"24","author":"Wei","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40170-022-00290-z","article-title":"ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma","volume":"10","author":"Klasson","year":"2022","journal-title":"Cancer Metab"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103035","article-title":"DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT","volume":"70","author":"Shen","year":"2024","journal-title":"Redox Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/pcmr.13009","article-title":"The role of ferroptosis in melanoma","volume":"35","author":"Talty","year":"2022","journal-title":"Pigment Cell Melanoma Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1049\/syb2.12081","article-title":"Prediction and analysis of genetic effect in idiopathic pulmonary fibrosis and gastroesophageal reflux disease","volume":"17","author":"Chen","year":"2023","journal-title":"IET Syst Biol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134629","article-title":"Structure of POU2AF1 recombinant protein and it affects the progression and treatment of liver cancer based on WGCNA and molecular docking analysis","volume":"278","author":"Li","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.013","article-title":"Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma","volume":"182","author":"Gillette","year":"2020","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.01.220","article-title":"Solid predominant subtype in lung adenocarcinoma is related to poor prognosis after surgical resection: A systematic review and meta-analysis","volume":"45","author":"Miyahara","year":"2019","journal-title":"Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00486-y","article-title":"SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B","volume":"3","author":"Ye","year":"2023","journal-title":"Nat Aging"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102929","article-title":"The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention","volume":"50","author":"Alhasaniah","year":"2025","journal-title":"Curr Probl Cardiol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100490R","article-title":"Emerging roles of Sirtuin 2 in cardiovascular diseases","volume":"35","author":"Taneja","year":"2021","journal-title":"FASEB J Off Publ Fed Am Societies For Exp Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1173869","article-title":"The LINC00152\/miR-138 axis facilitates gastric cancer progression by mediating SIRT2","volume":"2021","author":"Wang","year":"2021","journal-title":"J Oncol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1818835","article-title":"Immuno-inflammatory-metabolic interactions in cardiovascular diseases: A review from basic mechanisms to clinical translation","volume":"17","author":"Zhu","year":"2026","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/imr.12858","article-title":"Immunometabolism: From basic mechanisms to translation","volume":"295","author":"Makowski","year":"2020","journal-title":"Immunol Rev"},{"key":"B51","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/pros.24437","article-title":"SIRT2 promotes cell proliferation and migration through mediating ERK1\/2 activation and lactosylceramide accumulation in prostate cancer","volume":"83","author":"Lin","year":"2023","journal-title":"Prostate"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023155","article-title":"PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation","volume":"55","author":"Fu","year":"2023","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(95)00032-n","article-title":"Phosphatidylinositol 3-kinase: inhibition of intrinsic protein-serine kinase activity by phosphoinositides, and of lipid kinase activity by Mn2+","volume":"1267","author":"Chauhan","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901621RRR","article-title":"Expression and function of chondroitin 4-sulfate and chondroitin 6-sulfate in human glioma","volume":"34","author":"Pan","year":"2020","journal-title":"FASEB J Off Publ Fed Am Societies For Exp Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.588","article-title":"A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity","volume":"34","author":"Bajpe","year":"2015","journal-title":"Oncogene"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-008811","article-title":"Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma","volume":"12","author":"Chen","year":"2024","journal-title":"J Immunother Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12967-025-06243-6","article-title":"Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in LUAD","volume":"23","author":"Zhao","year":"2025","journal-title":"J Transl Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cac2.12250","article-title":"Ferroptosis in cancer and cancer immunotherapy","volume":"42","author":"Zhao","year":"2022","journal-title":"Cancer Commun (London England)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2174\/1566524022666220509124608","article-title":"Ferroptosis and cancer immunotherapy","volume":"23","author":"Yin","year":"2023","journal-title":"Curr Mol Med"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2236-y","article-title":"Epothilone B induces apoptosis and enhances apoptotic effects of ABT-737 on human cancer cells via PI3K\/AKT\/mTOR pathway","volume":"142","author":"Li","year":"2016","journal-title":"J Cancer Res Clin Oncol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.08.055","article-title":"Synthesis and antitumor activity of epothilone B","volume":"157","author":"Cheng","year":"2018","journal-title":"Eur J Med Chem"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2174\/1389557033405269","article-title":"Epothilone B and its analogs - a new family of anticancer agents","volume":"3","author":"Altmann","year":"2003","journal-title":"Mini-Rev Med Chem"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1900448\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:32:14Z","timestamp":1789101134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1900448\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":63,"alternative-id":["10.3389\/fonc.2026.1900448"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1900448","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"article-number":"1900448"}}