{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:10:43Z","timestamp":1788952243950,"version":"build-2803163510"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess temporal trends in incidence and mortality and project the future burden of five major digestive system cancers in Jiangsu Province, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Population-based cancer registry data from Jiangsu Province between 2010 and 2021 were used to analyze the burden of esophageal, gastric, colon, rectal, and liver cancers. Age-standardized incidence and mortality rates were calculated and compared by cancer type, sex, and urban-rural residence. Joinpoint regression was used to estimate annual percentage changes (APC) and average annual percentage changes (AAPC). The APC from the most recent Joinpoint segment was used to project incidence and mortality rates to 2030.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, gastric cancer had the highest age-standardized incidence and mortality among the five cancers. Incidence and mortality were consistently higher in males than in females and increased markedly after 50 years of age. From 2010 to 2021, age-standardized incidence and mortality declined for esophageal, gastric, and liver cancer, but increased for colon and rectal cancer. Colon cancer showed the steepest increase in both incidence and mortality. Rural areas showed faster increases in colon and rectal cancer burden than urban areas. Projections to 2030 suggest continued declines in esophageal, gastric, and liver cancer, while colon cancer incidence and mortality are expected to rise further.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Jiangsu Province is experiencing a transition in digestive system cancer burden, with continued declines in esophageal, gastric, and liver cancers but an emerging and growing burden of colorectal cancer, especially colon cancer. Prevention strategies should focus on expanding colorectal cancer screening and early diagnosis, particularly in rural areas, while sustaining control of esophageal, gastric, and liver cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1902194","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:17:10Z","timestamp":1788949030000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends and future burden of major digestive system cancers in Jiangsu Province, China, 2010\u20132030"],"prefix":"10.3389","volume":"16","author":[{"given":"Yanzheng","family":"Zou","sequence":"first","affiliation":[{"name":"National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic 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on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of VIP, The Affiliated Wuxi People\u2019s Hospital of Nanjing Medical University, Nanjing Medical University","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Pan","sequence":"additional","affiliation":[{"name":"National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases","place":["Wuxi, Jiangsu, 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