{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:28Z","timestamp":1788416008584,"version":"build-2803163510"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>This article reports on the diagnosis and treatment of a patient with a renal Ewing-like undifferentiated small round cell neoplasm. The patient, a 56-year-old man, presented to our hospital on March 14, 2025, complaining of \u201cblood clots in the urine for 2 days\u201d and \u201ca mass in the right kidney detected on physical examination 2 days prior.\u201d On March 21, 2025, he underwent a \u201cright renal mass needle biopsy\u201d under local infiltration anesthesia. Postoperative pathology: (right renal mass) malignant tumor with necrosis; immunohistochemical findings consistent with renal Ewing-like undifferentiated small round cell neoplasm. Postoperative follow-up: The patient\u2019s condition progressed after six cycles of chemotherapy. Immunotherapy combined with anti-angiogenic targeted therapy was planned but proved ineffective; the patient ultimately died of multiple organ failure.<\/jats:p>","DOI":"10.3389\/fonc.2026.1902656","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:22:16Z","timestamp":1788412936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast-enhanced ultrasound features of primary renal Ewing-like undifferentiated small round cell neoplasm: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Xueling","family":"Tang","sequence":"first","affiliation":[{"name":"School of Medical Imaging, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Yuhuangding Hospital","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14265","article-title":"Updates from the 2020 World Health Organization classification of soft tissue and bone tumours","volume":"78","author":"Anderson","year":"2021","journal-title":"Histopathology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-022-04093-7","article-title":"The 2020 World Health Organization classification of bone tumors: what radiologists should know","volume":"52","author":"Hwang","year":"2023","journal-title":"Skeletal Radiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/PAP.0000000000000284","article-title":"The 2020 WHO classification of tumors of soft tissue: selected changes and new entities","volume":"28","author":"Choi","year":"2021","journal-title":"Adv Anat Pathol"},{"key":"B4","first-page":"758","article-title":"A case of extraosseous Ewing sarcoma of the thigh muscle layer diagnosed by high-frequency ultrasound","volume-title":"Chinese Journal of Clinical Medical Imaging","author":"Chen","year":"2025"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1602157","article-title":"Undifferentiated small round cell sarcomas in the retroperitoneal space in a 12-year-old female: a rare case report","volume":"13","author":"Liu","year":"2025","journal-title":"Front Pediatr"},{"key":"B6","article-title":"Imaging findings in a case of primary Ewing\u2019s renal sarcoma","volume-title":"Chinese Journal of Clinical Medical Imaging","author":"Liang","year":"2025"},{"key":"B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12894-022-01146-w","article-title":"Extraosseous Ewing's sarcoma\/peripheral primitive neuroectodermal tumour of the kidney: a case report and literature review","volume":"22","author":"Li","year":"2022","journal-title":"BMC Urol"},{"key":"B8","article-title":"The diagnostic value of multimodal blood flow imaging for benign and malignant small renal tumors","volume-title":"Zhonghua Zhong Liu Za Zhi","author":"Li","year":"2026"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1212475","article-title":"Case report: Colon Malignant tumor caused by retroperitoneal small round cell undifferentiated sarcoma","volume":"13","author":"Wei","year":"2023","journal-title":"Front Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-024-03602-5","article-title":"Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS)","volume":"27","author":"Mata Fern\u00e1ndez","year":"2025","journal-title":"Clin Transl Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1902656\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:22:19Z","timestamp":1788412939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1902656\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":10,"alternative-id":["10.3389\/fonc.2026.1902656"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1902656","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"article-number":"1902656"}}