{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:46:32Z","timestamp":1785818792210,"version":"3.56.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Epstein\u2013Barr virus-associated gastric carcinoma (EBVaGC) typically presents as a solitary lesion in older men. We describe a 24-year-old woman with chronic diarrhea and immunosuppression who was found to have multiple gastric lesions. Laboratory evaluation revealed active EBV replication (2.55 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    copies\/mL) and severe CD4 lymphopenia (180\/\u03bcL). Esophagogastroduodenoscopy showed extensive gastric squamous metaplasia and multiple elevated lesions. The large antral mass was clinically suspected to represent advanced malignancy, and therefore, prompted distal gastrectomy, whereas the smaller fundic lesion was treated with endoscopic submucosal dissection. Histopathology unexpectedly revealed moderately-to-poorly differentiated adenocarcinomas with prominent lymphoid stroma at both sites.\n                    <jats:italic>In situ<\/jats:italic>\n                    hybridization confirmed EBV-encoded RNA positivity. Notably, both tumors were confined to the mucosa (pT1a), consistent with early gastric cancer. This case illustrates that EBVaGC may present as massive polypoid lesions mimicking advanced neoplasia in young, immunocompromised hosts. Careful integration of endoscopic and histopathological findings is essential for appropriate management.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1902713","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:27:54Z","timestamp":1785817674000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Massive polypoid early Epstein-Barr virus-associated gastric carcinoma in a young immunocompromised host"],"prefix":"10.3389","volume":"16","author":[{"given":"Ke","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College","place":["Nanchong, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chengdu Third People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biguang","family":"Tuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Qianxi People\u2019s Hospital","place":["Qianxi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, 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