{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:06:56Z","timestamp":1784696816343,"version":"3.55.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The preoperative application of computed tomography (CT), particularly suture hook anchor (SHA) and indocyanine green (IG) injection, for guiding the localization of pulmonary nodules (PNs) is increasingly used. Nevertheless, these two approaches have not been compared in terms of safety and performance. Here, the effectiveness and safety of CT-guided SHA and IG localization for multiple PNs during video-assisted thoracoscopic surgery (VATS) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive cases with multiple PNs that received SHA or IG under CT guidance before VATS between January 2022 and December 2024 were retrospectively analyzed. Localization success, procedure duration, complication rates, and VATS-related outcomes analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-four cases were enrolled, of which 36 (79 nodules) underwent SHA localization, and 38 (92 nodules) underwent IG localization. All patients successfully underwent one-stage localization and subsequent VATS resection. The technical success rates for both procedures were 100%. The IG-mediated procedure was markedly shorter than SHA (10.6 \u00b1 4.4\u00a0min vs. 23.4 \u00b1 11.9\u00a0min, P\u00a0=\u00a00.001). The incidence of pneumothorax (27.8% vs. 36.8%, P\u00a0=\u00a00.405) and pulmonary hemorrhage (38.9% vs. 21.1%, P\u00a0=\u00a00.093) was comparable between the two procedures. VATS limited resections were technically successful in all patients (100% in both groups), with all nodules resected in a single operative session. The median operative duration was comparable between the SHA and IG groups (85 minutes vs. 80 minutes, P\u00a0=\u00a00.269).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both SHA and IG-mediated localization under CT guidance safe and effective for the preoperative evaluation of multiple PNs. While outcomes were similar across both methods, IG localization demonstrated the advantage of significantly reduced localization time, suggesting it may be a more time-efficient option in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1905816","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:50:14Z","timestamp":1784695814000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of CT-guided suture hook anchor and indocyanine green localization for multiple pulmonary nodules"],"prefix":"10.3389","volume":"16","author":[{"given":"Yu-Tao","family":"Xian","sequence":"first","affiliation":[{"name":"Department of Radiology, Ningbo Medical Center Lihuili Hospital","place":["Ningbo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xuzhou Central Hospital","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Tian","family":"An","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xuzhou Central Hospital","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bo","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ningbo Medical Center Lihuili Hospital","place":["Ningbo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2019-0069","article-title":"Pulmonary nodules precision localization techniques","volume":"16","author":"Nardini","year":"2020","journal-title":"Future Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.10.60","article-title":"Preoperative computed tomography-guided pulmonary nodule localization augmented by laser angle guide assembly","volume":"11","author":"Tsai","year":"2019","journal-title":"J Thorac Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13726","article-title":"Preoperative pulmonary nodule localization: A comparison of hook wire and Lung-pro-guided surgical markers","volume":"18","author":"He","year":"2024","journal-title":"Clin Respir J"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2017.0484","article-title":"Coil localization-guided video-assisted thoracoscopic surgery for lung nodules","volume":"28","author":"Fu","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2022.2133965","article-title":"Preoperative computed tomography-guided localization for multiple lung nodules: a meta-analysis","volume":"31","author":"Wang","year":"2022","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2023.134158","article-title":"Preoperative computed tomography-guided localization for pulmonary nodules: Comparison between hook-wire and anchored needle localization","volume":"19","author":"Zhou","year":"2024","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-1272","article-title":"Factors influencing the accuracy and safety of preoperative computed tomography (CT)-guided soft hook-wire localization for pulmonary nodules: a comprehensive analysis","volume":"14","author":"Feng","year":"2024","journal-title":"Quant Imaging Med Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.20452\/wiitm.2024.17910","article-title":"Preoperative computed tomography-guided localization of pulmonary ground-glass nodules: a comparison of conventional and soft hook-wires","volume":"19","author":"Fan","year":"2024","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2022.119767","article-title":"Preoperative lung nodule localization: Comparison of hook-wire and indocyanine green","volume":"18","author":"Lin","year":"2023","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.21203\/rs.3.rs-1840601\/v1","article-title":"Comparison of the effectiveness of anchoring needles and coils in localizing multiple nodules in the lung","volume":"22","author":"Huang","year":"2022","journal-title":"BMC Pulm Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1501165","article-title":"Preoperative computed tomography-guided soft hook-wire localization for multiple pulmonary nodules","volume":"15","author":"Li","year":"2025","journal-title":"Front Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2023.124272","article-title":"Computed tomography-guided indocyanine green localization of multiple ipsilateral lung nodules","volume":"18","author":"Lin","year":"2023","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08101-7","article-title":"Computed tomography-guided cyanoacrylate injection for localization of multiple ipsilateral lung nodules","volume":"32","author":"Xu","year":"2022","journal-title":"Eur Radiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2016.02.27","article-title":"Hybrid theatre and alternative localization techniques in conventional and single-port video-assisted thoracoscopic surgery","volume":"8","author":"Zhao","year":"2016","journal-title":"J Thorac Dis"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1905816\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:50:22Z","timestamp":1784695822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1905816\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":14,"alternative-id":["10.3389\/fonc.2026.1905816"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1905816","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1905816"}}