{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:04:25Z","timestamp":1790597065858,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Prion proteins (PrP) are primarily known for their role in neurodegenerative conditions like Creutzfeldt-Jakob Disease, where the misfolded, pathogenic isoform PrPSc propagates by using the normal cellular prion protein, PrP\n                    <jats:sup>c<\/jats:sup>\n                    , as a template, leading to aggregation and neuronal death. PrP\n                    <jats:sup>c<\/jats:sup>\n                    is a widely expressed glycoprotein that, beyond its role in prion disease, has emerged in specific contexts as a modulator of several hallmark cancer processes, including proliferation, apoptosis resistance, cellular signaling, adhesion, survival, and motility. This paper explores current evidence on how PrP\n                    <jats:sup>c<\/jats:sup>\n                    , and its misprocessed isoform pro-PrP, contribute to tumor progression across multiple cancer types, using colorectal cancer (CRC) as a unifying disease model to integrate mechanisms that are otherwise dispersed across the literature. This review will examine PrP\n                    <jats:sup>c<\/jats:sup>\n                    \u2019s role in sustaining proliferative signaling, resisting apoptosis, promoting migration and metastasis through its interaction with filamin A (FLNa), and contributing to therapy resistance. The goal is to consider the extent to which these mechanisms converge specifically in CRC, and what this means for PrP\n                    <jats:sup>c<\/jats:sup>\n                    \u2019s potential as a diagnostic and therapeutic target.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1906977","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:44:35Z","timestamp":1790595875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Implications of cellular prion protein in tumor biology"],"prefix":"10.3389","volume":"16","author":[{"given":"Ahmed","family":"Damra","sequence":"first","affiliation":[{"name":"Department of Pathology, Case Western Reserve University","place":["Cleveland, OH, United 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