{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:44:14Z","timestamp":1785908654783,"version":"3.56.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy and safety of\n                      <jats:sup>192<\/jats:sup>\n                      Ir brachytherapy combined with external beam radiotherapy (EBRT) and biliary stenting in patients with unresectable hilar cholangiocarcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Clinical data of 62 patients with unresectable hilar cholangiocarcinoma were retrospectively analyzed. All patients received concurrent chemoradiotherapy plus percutaneous biliary stenting. Among them, 32 patients (\n                      <jats:sup>192<\/jats:sup>\n                      Ir group) additionally received\n                      <jats:sup>192<\/jats:sup>\n                      Ir brachytherapy, and 30 patients (EBRT group) received EBRT alone. Survival outcomes were analyzed using the Kaplan\u2013Meier method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3 months after treatment, the objective response rate was 93.8% in the\n                      <jats:sup>192<\/jats:sup>\n                      Ir group and 70.0% in the EBRT group. Median progression-free survival was 11.2 months vs 8.6 months (P\u00a0=\u00a00.032), and median overall survival was 14.5 months vs 12.2 months (P\u00a0=\u00a00.361). Liver function parameters and CA19\u20139 levels decreased in both groups, with significantly lower levels in the\n                      <jats:sup>192<\/jats:sup>\n                      Ir group at 3 months. Adverse events were tolerable in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:sup>192<\/jats:sup>\n                      Ir brachytherapy plus EBRT and biliary stenting may improve short-term tumor response and progression-free survival in unresectable hilar cholangiocarcinoma, with tolerable toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1909866","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:47:44Z","timestamp":1785905264000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["192Ir brachytherapy combined with external beam radiotherapy and biliary stenting for unresectable hilar cholangiocarcinoma"],"prefix":"10.3389","volume":"16","author":[{"given":"Wenbo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Head, Neck and Thoracic Medical Oncology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine-Hebei","place":["Cangzhou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Second General Surgery, Hengshui Fifth People\u2019s Hospital","place":["Hengshui, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Thoracic Medical Oncology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine-Hebei","place":["Cangzhou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Thoracic Medical Oncology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine-Hebei","place":["Cangzhou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Thoracic Medical Oncology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine-Hebei","place":["Cangzhou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Head, Neck and Thoracic Medical Oncology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine-Hebei","place":["Cangzhou, Hebei, 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