{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:24:43Z","timestamp":1786944283832,"version":"build-2736575974"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary breast lymphoma (PBL) is an exceedingly rare extranodal malignancy that frequently mimics breast carcinoma on clinical and radiological examination, posing a significant diagnostic challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a case of a 39-year-old Chinese woman who presented with two palpable right breast masses. Imaging revealed suspicious lesions classified as Breast Imaging-Reporting and Data System 4A, prompting surgical excision and biopsy. Histopathological examination and immunohistochemical (IHC) analysis confirmed a diagnosis of diffuse large B-cell lymphoma, germinal center B-cell subtype. Staging by 18F-fluorodeoxyglucose positron emission tomography\/computed tomography established disease as Ann Arbor stage IE, asymptomatic (stage IEA) with an International Prognostic Index score of 0. The patient was initiated on R-CHOP chemoimmunotherapy and demonstrated a favorable response after three cycles, with no evidence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of histopathological and IHC evaluation in differentiating PBL from breast carcinoma. Early and accurate diagnosis is essential to guide appropriate treatment and optimize patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1911895","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:36:24Z","timestamp":1786941384000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary breast diffuse large B-cell lymphoma mimicking breast carcinoma: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Renda","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Dongyang Hospital Affiliated to Wenzhou Medical University","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Dongyang Hospital Affiliated to Wenzhou Medical University","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luning","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Dongyang Hospital Affiliated to Wenzhou Medical University","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Dongyang Hospital Affiliated to Wenzhou Medical University","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guinv","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Dongyang Hospital Affiliated to Wenzhou Medical University","place":["Dongyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1653826","article-title":"Primary breast diffuse large B-cell lymphoma (germinal center B-cell-like subtype): a case report and literature review","volume":"15","author":"Xing","year":"2025","journal-title":"Front Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-321","article-title":"Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma; 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