{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:04:45Z","timestamp":1789362285297,"version":"build-2803163510"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oncological prehabilitation aims to strengthen cancer patients physically and mentally before treatment, yet it is not standard care. The Prehabilitation through an Integrative Medicine Day Clinic (PRIME-DC) study examined the feasibility of a multimodal program during neoadjuvant therapy prior to surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>In this single-arm, mono-center interventional feasibility trial, patients attended a closed-group program once weekly for eight weeks (6.5-hour sessions) scheduled across the neoadjuvant treatment period. The curriculum integrated physical exercise, nutritional and naturopathic counseling, and Mind-Body Medicine practices. The primary outcome was program adherence, defined by attendance rate. Secondary outcomes included patient-reported measures of quality of life, anxiety, depression, fatigue, sleep, mindfulness, and physical fitness tests assessed at baseline and post-intervention. Patient satisfaction were evaluated at program completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-three of the 41 patients who were assessed for eligibility were enrolled, with an adherence rate of 69%. An exploratory within-group improvement in the 1-minute sit-to-stand test was observed from baseline to post-intervention (V1: 26.00 (22.00\/34.00), V10a: 27.00 (24.99\/34.00), 95% CI = 1.000 \u2013 6.000, p = 0.02, r = 0.66), while other functional and patient-reported outcomes showed no statistically detectable within-group changes (p &amp;gt; 0.05). No study-related adverse events occurred. Patient satisfaction was assessed using a 17-item Likert scale (0\u20134). Overall, patients reported high levels of satisfaction (range: 0.00 - 1.88).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This pilot feasibility study provides preliminary evidence that participation in an integrative prehabilitation day-clinic program may be associated with the preservation of physical and mental health during neoadjuvant treatment. The findings indicate good feasibility and acceptability, providing a strong rationale for further investigation in larger, controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/drks.de\/search\/de\/trial\/DRKS00028126<\/jats:ext-link>\n                      , identifier DRKS00028126.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1913126","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:35:28Z","timestamp":1789360528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prehabilitation for patients undergoing neoadjuvant treatment: results of a single-center pilot study using an integrative medicine day clinic"],"prefix":"10.3389","volume":"16","author":[{"given":"Svenja","family":"Klaus-Karwisch","sequence":"first","affiliation":[{"name":"Section Integrative Medicine, Department of General and Visceral Surgery, Ulm University Medical Center, Ulm University","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Otto","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Ulm (CCCU), Ulm University Hospital","place":["Ulm, Germany"]},{"name":"Department of Gynaecology and Obstetrics, Ulm University Hospital","place":["Ulm, Germany"]},{"name":"Department of Internal Medicine I, Ulm University Hospital","place":["Ulm, Germany"]},{"name":"Department of Internal Medicine III, Ulm University Hospital","place":["Ulm, Germany"]},{"name":"Fascia Research Society (FRS)","place":["Burnsville, MN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Georg","family":"Werthmann","sequence":"additional","affiliation":[{"name":"Section Integrative Medicine, Department of General and Visceral Surgery, Ulm University Medical Center, Ulm University","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Lederer","sequence":"additional","affiliation":[{"name":"Section Integrative Medicine, Department of General and Visceral Surgery, Ulm University Medical Center, Ulm University","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Leopold","family":"Mihaljevic","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University Hospital Tuebingen","place":["T\u00fcbingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fynn","family":"Treiber","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, University 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