{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:13Z","timestamp":1787721673096,"version":"build-2784847793"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"\n Background<\/jats:title>\n Anthracycline-based chemotherapy improves breast cancer outcomes but may cause cancer therapy-related cardiac dysfunction (CTRCD). Biomarkers reflecting inflammatory and metabolic myocardial stress may complement imaging surveillance, but the combined value of galectin-9 (Gal-9), fatty-acid-binding protein 4 (FABP4) and pentraxin-3 (PTX-3) is unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to evaluate whether serum Gal-9, FABP4 and PTX-3 are associated with myocardial dysfunction and discriminate CTRCD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This single-centre retrospective cohort included 219 women receiving at least three anthracycline-based cycles from December 2022 to June 2025. Patients were classified as CTRCD (n = 66) or non-CTRCD (n = 153) using ASE\/EACVI and ESC criteria. Baseline and post-cycle-3 echocardiography and hs-cTnI were recorded; post-cycle-3 biomarkers were measured by ELISA. Analyses included adjusted correlations, multivariable logistic regression, ROC\/DeLong testing and bootstrap validation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Baseline characteristics were comparable. After chemotherapy, Gal-9, FABP4 and PTX-3 were higher, whereas LVEF, |GLS| and MCI were lower, in the CTRCD group (all P &lt; 0.05). Biomarkers correlated inversely with LVEF, |GLS| and MCI after adjustment (all P &lt; 0.001). The combined biomarker score was independently associated with CTRCD (adjusted OR 3.25 per SD; 95% CI 2.09\u20135.07; P &lt; 0.001). The combined model achieved an AUC of 0.880 (95% CI 0.829\u20130.920), optimism-corrected AUC of 0.854 and cross-validated AUC of 0.846, improving the clinical-model AUC from 0.642 to 0.872 (P &lt; 0.001).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Gal-9, FABP4 and PTX-3 were associated with concurrent myocardial dysfunction and improved discrimination of on-treatment CTRCD. This candidate adjunctive panel requires serial sampling and external validation before clinical use.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fonc.2026.1913970","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:53:40Z","timestamp":1787720020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Galectin-9, FABP4 and pentraxin-3 are associated with myocardial dysfunction and discriminate chemotherapy-related cardiac dysfunction in anthracycline-treated breast cancer: a single-centre retrospective study"],"prefix":"10.3389","volume":"16","author":[{"given":"Jincheng","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The 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