{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:55Z","timestamp":1787721715777,"version":"build-2784847793"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010590","name":"Tianjin Municipal Bureau of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Lacrimal adenoid cystic carcinoma (LACC) is the most common malignant epithelial tumor of the lacrimal gland, with particularly high recurrence and mortality in cases with high-grade transformation (HGT-LACC). This study aims to investigate the functional role of miR-150-5p in regulating the HGT of LACC. MiRNA microarray and proteomic mass spectrometry were performed on paired LACC and HGT-LACC tissues to identify differentially expressed miR-150-5p and its potential target COL1A1. The miR-150-5p\/COL1A1 interaction was validated by luciferase reporter assay, and the effects of miR-150-5p on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) were assessed\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    via colony formation, wound healing, Transwell assays, and xenograft models. MiR-150-5p was significantly downregulated in HGT-LACC and correlated with poor prognosis. Overexpression of miR-150-5p suppressed cell proliferation, migration and invasion, while its knockdown showed opposite effects. COL1A1 was confirmed as the direct target of miR-150-5p, and COL1A1 restoration counteracted the tumor-suppressive effect of miR-150-5p.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , miR-150-5p overexpression inhibited tumor growth. Overall, our findings demonstrate that miR-150-5p suppresses LACC cell proliferation, migration, invasion, and EMT by downregulating COL1A1 expression, thereby functioning as a tumor suppressor. The miR-150-5p-COL1A1 axis provides novel insights into the pathogenesis of LACC and serves as a promising therapeutic target for LACC intervention.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1915447","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:53:44Z","timestamp":1787720024000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR-150-5p suppresses high-grade transformation of lacrimal adenoid cystic carcinoma by downregulating COL1A1"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoyu","family":"Zhu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital","place":["Tianjin, 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Medical University Eye Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Early Drug Evaluation of Innovative Drugs, Tianjin International Joint Academy of Biomedicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Lin","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and 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