{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:00:28Z","timestamp":1785218428338,"version":"3.55.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sinonasal NUT carcinoma is a rare and highly aggressive malignancy, frequently diagnosed at advanced stages with poor prognosis. Intracranial spread is uncommon and, to our knowledge, leptomeningeal carcinomatosis has not been previously reported in sinonasal NUT carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>\n                      We describe the clinical, radiological, histopathological, and molecular features of a 32-year-old woman with sinonasal NUT carcinoma who developed leptomeningeal carcinomatosis. The patient presented with a rapidly progressive nasoethmoidal mass with intracranial (dural) invasion. Diagnosis was confirmed by nuclear NUT immunoreactivity and identification of a\n                      <jats:italic>BRD4::NUTM1<\/jats:italic>\n                      fusion. Despite partial response to induction chemotherapy, the disease evolved with neurological deterioration and radiological findings consistent with contiguous intra-axial and diffuse leptomeningeal involvement, leading to death four months after diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sinonasal NUT carcinoma with intracranial and meningeal extension may evolve to leptomeningeal carcinomatosis. Early diagnosis and multimodal treatment, including early surgery, may be crucial to improve prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1915873","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:38:02Z","timestamp":1785217082000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Leptomeningeal carcinomatosis in sinonasal NUT carcinoma: a case report and review of intracranial involvement"],"prefix":"10.3389","volume":"16","author":[{"given":"Francisco Manuel","family":"Rodr\u00edguez-Santiago","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inter-hospital Cardiology Unit, San Cecilio University Hospital","place":["Granada, Spain"]},{"name":"Cardiology Section, Department of Internal Medicine, Santa Ana Hospital","place":["Motril, Granada, Spain"]},{"name":"FLG-NUT Foundation","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sequero L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, San Cecilio University Hospital","place":["Granada, Spain"]},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (ibs.GRANADA)","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Jes\u00fas","family":"L\u00e1inez-Ramos-Bossini","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (ibs.GRANADA)","place":["Granada, Spain"]},{"name":"Department of Radiology, Virgen de las Nieves University Hospital","place":["Granada, Spain"]},{"name":"Department of Human Anatomy and Embryology, School of Medicine, University of Granada","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"B1","volume-title":"Head and Neck Tumours","year":"2022"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12727","article-title":"NUT carcinoma: Clinicopathologic features, pathogenesis, and treatment","volume":"68","author":"French","year":"2018","journal-title":"Pathol Int"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26067","article-title":"Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review","volume":"42","author":"Lee","year":"2020","journal-title":"Head Neck"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107496","article-title":"Clinical management of NUT carcinoma (NC) in Germany: Analysis of survival, therapy response, tumor markers and tumor genome sequencing in 35 adult 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