{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:55:02Z","timestamp":1790596502779,"version":"4.1.0"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cervical cancer is one of the most common malignancies of the female reproductive system worldwide, and its development is closely associated with persistent infection with high-risk human papillomavirus (HPV). \u03b3\u03b4 T cells, as key effector cells bridging innate and adaptive immunity, exert unique and complex regulatory functions in tumor immune surveillance. However, the distribution patterns, functional polarization states, and antitumor mechanisms of distinct \u03b3\u03b4 T-cell subsets within the cervical cancer microenvironment have not yet been systematically elucidated, and the impact of HPV infection on the functional remodeling of \u03b3\u03b4 T-cell subsets remains controversial. This review summarizes the distribution characteristics and functional polarization states of the major \u03b3\u03b4 T-cell subsets, including V\u03b41, V\u03b42, and V\u03b43 T cells, in the cervical cancer microenvironment. We further discuss the molecular mechanisms through which these subsets participate in immune surveillance via T-cell receptor (TCR) signaling, NKG2D-mediated recognition, Fas\/FasL signaling, and cytokine secretion, and examine the regulatory effects of HPV infection on \u03b3\u03b4 T-cell subset remodeling. In addition, recent preclinical advances in \u03b3\u03b4 T-cell subset-based adoptive immunotherapy and combination strategies involving immune checkpoint blockade in cervical cancer are reviewed. Overall, this review aims to provide a theoretical basis and new perspectives for optimizing immunotherapeutic targets and developing individualized treatment strategies for cervical cancer.<\/jats:p>","DOI":"10.3389\/fonc.2026.1919105","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:54:50Z","timestamp":1790592890000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in \u03b3\u03b4 T cell-mediated immune surveillance in cervical cancer"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinlei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Shengli Oilfield Central Hospital","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Shengli Oilfield Central Hospital","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Shengli Oilfield Central Hospital","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2023.110724","article-title":"Function of gamma delta (\u03b3\u03b4) T cell in cancer with special emphasis on cervical cancer","volume":"84","author":"Patra","year":"2023","journal-title":"Hum Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2016.27.e59","article-title":"Carcinoma of the cervix in elderly patients treated with radiotherapy: patterns of care and treatment outcomes","volume":"27","author":"Lin","year":"2016","journal-title":"J Gynecol 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