{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:11:55Z","timestamp":1789038715384,"version":"build-2803163510"},"reference-count":191,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cervical cancer represents a global public health problem, hence the importance of optimizing therapeutic options and expanding knowledge of prognostic markers. Clinical and experimental evidence shows that hypoxia-inducible factor (HIF) is a key inducer of aggressive phenotypes in cervical cancer: promoting angiogenesis, invasion, epithelial-mesenchymal transition (EMT), modulation of the immune microenvironment, and contributing to resistance to radiotherapy\/chemotherapy in a possible synergistic effect with the human papilloma virus oncogenes. Hypoxic microenvironments that modulate the early activation of HIF pathways may be present in pre-invasive lesions and favor the acquisition of invasive phenotypes that precede invasion. This review highlights the mechanisms of HIF-1\u03b1 in the progression of cervical intraepithelial neoplasia and cervical cancer. In this regard, HIF-1\u03b1 is involved in the expression of genes related to angiogenesis, apoptosis and progression such as GLUT1, uPAR, BIRC5, EPO, EpoR, LIMD1, VHL, MET and pro-angiogenic genes (VEGF, PGF, PDGF-\u03b2, PAI-1, MMP-2, MMP-9, ANG-1, ANG-2, using pathways such as YAP\/TA2. However, the balance between antitumor factors (miR-143) and protumor factors can define the progression of this neoplasia. In the future, the characterization of hypoxia signatures and the evaluation of HIF-1\u03b1 pathway inhibitors are promising tools for optimizing outcomes in the treatment of cervical cancer, integrated with modern, high-precision radiation therapy techniques and predictive models based on imaging and artificial intelligence, which represent a key pillar of personalized oncology in cervical cancer, with the potential to improve tumor control and reduce toxicity; however, specific clinical trials are still needed to validate their impact on survival and safety.<\/jats:p>","DOI":"10.3389\/fonc.2026.1922814","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:47:57Z","timestamp":1789037277000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of hypoxia-inducible factor \u2013 1 alpha on the progression of cervical intraepithelial neoplasia and cervical cancer: a narrative review"],"prefix":"10.3389","volume":"16","author":[{"given":"Yenddy N.","family":"Carrero","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Human Development, Universidad Ecotec","place":["Samborond\u00f3n, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas A.","family":"Mosquera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Cl\u00ednicas \u201cDr. Am\u00e9rico Negrette\u201d, Facultad de Medicina, Universidad del Zulia","place":["Maracaibo, Venezuela"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.020","article-title":"Metabolic adaptation in hypoxia and cancer","volume":"502","author":"Paredes","year":"2021","journal-title":"Cancer Lett"},{"key":"B3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.trecan.2016.05.006","article-title":"Hypoxia: Signaling the metastatic cascade","volume":"2","author":"Rankin","year":"2016","journal-title":"Trends Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127229","article-title":"Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1\u03b1 expression: a meta-analysis including 6,612 subjects","volume":"10","author":"Jin","year":"2015","journal-title":"PloS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-019-1517-0","article-title":"Targeting hypoxia in tumor: a new promising therapeutic strategy","volume":"39","author":"Bosco","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13045-022-01292-6","article-title":"Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape","volume":"15","author":"Wu","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B7","unstructured":"Factor inducible por hipoxia en c\u00e1ncer\n          \n          \n            \n              Aldecoa Bedoya Franklin\n            \n          \n          Horiz. 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