{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:18:41Z","timestamp":1787894321634,"version":"build-2784847793"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer continues to cause a high degree of morbidity and mortality worldwide, making it essential for new, safer, and more effective therapies to be developed. Aromatic plants provide researchers with diverse secondary metabolites that may have useful pharmacological effects. This systematic review examines several aromatic plants that were used medicinally in the past but have not been examined recently for their potential to produce new bioactive molecules with anticancer activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protocol for this systematic review followed PRISMA 2020, and it aimed to assess the anticancer potential of bioactive compounds obtained from underexplored aromatic plants. Peer-reviewed articles reporting phytochemical isolation, structural characterization, biological evaluation, and mechanistic investigations were systematically retrieved and analyzed. Data on plant species, bioactive compounds, identification methods, cancer models, molecular targets, pharmacological activities, and translational evidence were extracted and synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this review, a variety of phytochemicals that exhibit strong anticancer effects were identified, including the following: monoterpenes, sesquiterpenes, diterpenoids, triterpenoids, flavonoids, steroid compounds and phenylpropanoids. In addition to the existing identified compounds, several new phytochemicals, named epunctanone, PCPT-1, aspiletrein A, paeoniflorigenone, 7,8-epoxynagilactone, compound 5o, and new derivatives of phorbol esters, demonstrated powerful cytotoxic activities in many cancer models. The mechanism by which these phytochemicals exert their anticancer effect has been studied, and several pathways identified including: induction of apoptosis, blockage of cell-cycle progression, modulation of oxidative stress, inhibition of angiogenesis and metastasis, as well as regulation of various critical kinase signaling pathways (e.g. PI3K\/Akt\/mTOR, MAPK, STAT3, EGFR, NF-\u03baB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Underexplored aromatic plants are a promising source of structurally diverse bioactive compounds with encouraging anticancer activity in preclinical studies. However, there is no convincing evidence from high-quality human clinical trials that essential oils or their constituents can directly treat or cure cancer. Further rigorous preclinical and clinical studies are needed to establish their safety and therapeutic efficacy. Challenges including phytochemical standardization, limited pharmacokinetic and toxicological data, insufficient\n                      <jats:italic>in vitro<\/jats:italic>\n                      validation, and lack of clinical studies continue to obstruct translational progress. Future research integrating advanced phytochemical characterization, molecular oncology, AI-assisted drug discovery, and nanotechnology-based delivery systems may facilitate the development of aromatic plant-derived anticancer therapeutics.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1924878","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:32:10Z","timestamp":1787891530000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncharted phytochemical frontiers: a systematic review of novel bioactive compounds from underexplored aromatic plants for cancer therapy"],"prefix":"10.3389","volume":"16","author":[{"given":"Biswabhusan","family":"Dash","sequence":"first","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himadri Tanaya","family":"Behera","sequence":"additional","affiliation":[{"name":"Imgenex India Pvt. Ltd.","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.G.","family":"Unnoottee","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swagat","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divaker","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Phytochemistry, Pharmacy Academy, Faculty of Pharmacy, IFTM University","place":["Moradabad, Uttar Pradesh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Jena","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asit","family":"Ray","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap Chandra","family":"Panda","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Nayak","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambika","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be University)","place":["Bhubaneswar, Odisha, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: A Cancer J For Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA: A Cancer J For Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","article-title":"Tumour heterogeneity and resistance to cancer therapies","volume":"15","author":"Dagogo-Jack","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071144","article-title":"Essential oils: Chemistry and pharmacological activities","volume":"13","author":"De Sousa","year":"2023","journal-title":"Biomolecules"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2024.100549","article-title":"Terpenoids in essential oils: Chemistry, classification, and potential impact on human health and industry","volume":"4","author":"Siddiqui","year":"2024","journal-title":"Phytomed Plus"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010070","article-title":"Biological activities of essential oils: From plant chemoecology to traditional healing systems","volume":"22","author":"Sharifi-Rad","year":"2017","journal-title":"Molecules"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.084","article-title":"Stabilization of Zataria essential oil with pectin-based nanoemulsion for enhanced cytotoxicity in monolayer and spheroid drug-resistant breast cancer cell cultures and deciphering its binding mode with gDNA","volume":"164","author":"Salehi","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.cd-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2016.1225105","article-title":"Inhibitory kinetics and mechanism of flavonoids extracted from Cotinus coggygria Scop. against glioblastoma cancer","volume":"68","author":"Wang","year":"2016","journal-title":"Nutr Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071749","article-title":"Anticancer activities of Thymus vulgaris L. in experimental breast carcinoma in vitro and in vitro","volume":"20","author":"Kubatka","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061399","article-title":"Chemopreventive and therapeutic efficacy of Cinnamomum zeylanicum L. bark in experimental breast carcinoma: mechanistic in vitro and in vitro analyses","volume":"25","author":"Kubatka","year":"2020","journal-title":"Molecules"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c07782","article-title":"Network pharmacology combined with molecular docking, molecular dynamics, and in vitro experimental validation reveals the therapeutic potential of Thymus vulgaris L. essential oil (thyme oil) against human breast cancer","volume":"8","author":"Alotaibi","year":"2023","journal-title":"ACS Omega"},{"key":"B16","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12906-018-2274-x","article-title":"Chemical composition, antioxidant, antimicrobial and antiproliferative activities of essential oil of Mentha spicata L. (Lamiaceae) from Algerian Saharan atlas","volume":"18","author":"Bardaweel","year":"2018","journal-title":"BMC Complementary Altern Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.994025","article-title":"Ethanolic extract of Origanum Syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties","volume":"13","author":"Mesmar","year":"2022","journal-title":"Front Pharmacol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/biom10070988","article-title":"Bioactive natural compounds and antioxidant activity of essential oils from spice plants: New findings and potential applications","volume":"10","author":"Diniz do Nascimento","year":"2020","journal-title":"Biomolecules"},{"key":"B19","doi-asserted-by":"publisher","first-page":"E2212697X402539","DOI":"10.2174\/012212697x402539251001062221","article-title":"Medicinal potential of tropical rainforest plants in cancer therapy: Challenges and innovations","volume":"11","author":"Gulati","year":"2025","journal-title":"Clin Cancer Drugs"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/plants15050784","article-title":"Chrysopogon zizanioides (Vetiver) essential oil from Qatar targets AKT1 and STAT3 in colorectal and lung cancer: GC-MS profiling, In vitro antiproliferative activity, and in silico analyses","volume":"15","author":"Karousa","year":"2026","journal-title":"Plants"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13807","article-title":"Hedychium spicatum rhizome essential oil induces apoptosis in human prostate adenocarcinoma PC-3 cells via mitochondrial stress and caspase activation","volume":"9","author":"Ray","year":"2023","journal-title":"Heliyon"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0045-1815304","article-title":"Systematic fractionation using Complementary Developing Solvent technique in flash chromatography: A key step in dereplication strategies for natural products","volume":"92","author":"Fauquet","year":"2026","journal-title":"Planta Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.12.016","article-title":"Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells","volume":"48","author":"Mbaveng","year":"2018","journal-title":"Phytomedicine"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104886","article-title":"Phenylpropanoid-conjugated pentacyclic triterpenoids from the whole plants of Leptopus lolonum induced cell apoptosis via MAPK and Akt pathways in human hepatocellular carcinoma cells","volume":"111","author":"Qi","year":"2021","journal-title":"Bioorg Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12906-021-03262-w","article-title":"Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells","volume":"21","author":"Nguyen","year":"2021","journal-title":"BMC Complementary Med Ther"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115000","article-title":"Paeoniflorigenone regulates apoptosis, autophagy, and necroptosis to induce anti-cancer bioactivities in human head and neck squamous cell carcinomas","volume":"288","author":"Park","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2018.01.007","article-title":"7\u03b1, 8\u03b1-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities","volume":"125","author":"Zheng","year":"2018","journal-title":"Fitoterapia"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1159\/000479900","article-title":"Comprehensive analysis of the chemical composition and in vitro cytotoxic mechanisms of Pallines spinosa flower and leaf essential oils against breast cancer cells","volume":"42","author":"Saleh","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B29","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12906-024-04390-9","article-title":"Chemical composition, anticancer, antimicrobial activity of Aloysia citriodora Palau essential oils from four different locations in Palestine","volume":"24","author":"Al-Maharik","year":"2024","journal-title":"BMC Complementary Med Ther"},{"key":"B30","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s12032-024-02523-1","article-title":"Comparative evaluation of anticancer potential of Spilanthes paniculata leaf and flower essential oil using annexin V and orosphere formation in oral cancer cell line","volume":"41","author":"Satapathy","year":"2024","journal-title":"Med Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s13205-026-04759-2","article-title":"Tumor-suppressing efficacy of essential oil of Boswellia serrata gum resin and its synergistic effect on doxorubicin-induced growth inhibition of breast cancer cells","volume":"16","author":"Zhang","year":"2026","journal-title":"3 Biotech"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.12659\/msm.934475","article-title":"Review articles, systematic reviews, meta-analysis, and the updated preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 guidelines","volume":"27","author":"Parums","year":"2021","journal-title":"Med Sci Monitor: Int Med J Exp Clin Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"32463","DOI":"10.1038\/s41598-025-18314-1","article-title":"Broad-spectrum bioactivities and therapeutic potential of essential oils of certain aromatic and medicinal plants and their combination","volume":"15","author":"Abdalla","year":"2025","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26104737","article-title":"Evaluating the chemical composition and antitumor activity of Origanum vulgare ssp. hirtum essential oil in a preclinical colon cancer model","volume":"26","author":"Aindelis","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1862256","article-title":"PLGA-based nano-encapsulation of Trachyspermum ammi seed essential oil (TSEO-PNP) as a safe, natural, efficient, anticancer compound in human HT-29 colon cancer cell line","volume":"73","author":"Almnhawy","year":"2021","journal-title":"Nutr Cancer"},{"key":"B36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s12032-026-03245-2","article-title":"Phytochemical and pharmacological elucidation of Jasonia glutinosa (L.) fourr. essential oil: a promising therapeutic source against inflammation and cancer","volume":"43","author":"Baraich","year":"2026","journal-title":"Med Oncol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24122344","article-title":"Essential oil of Mentha aquatica var. Kenting water mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib","volume":"24","author":"Chang","year":"2019","journal-title":"Molecules"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020351","article-title":"Cytotoxicity and apoptosis induction of 6, 7-dehydroroyleanone from Taiwania cryptomerioides bark essential oil in hepatocellular carcinoma cells","volume":"14","author":"Chen","year":"2022","journal-title":"Pharmaceutics"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23112974","article-title":"Antitumor effect of the essential oil from the leaves of Croton matourensis Aubl.(Euphorbiaceae)","volume":"23","author":"Lima","year":"2018","journal-title":"Molecules"},{"key":"B40","doi-asserted-by":"publisher","first-page":"153153","DOI":"10.1016\/j.bbrc.2025.153153","article-title":"Revealing the antitumor mechanisms of aromatic oil from Amomum villosum through integrated network pharmacology, bioinformatics, machine learning, single-cell sequencing, and cell experiments","volume":"796","author":"Deng","year":"2026","journal-title":"Biochem Biophys Res Commun"},{"key":"B41","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3390\/molecules31030470","article-title":"Chemical profiling, molecular docking, and mechanistic anticancer activity of Pinus sylvestris essential oil in SH-SY5Y and U-87MG cells","volume":"31","author":"Dervi\u015fo\u011flu","year":"2026","journal-title":"Molecules"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27186106","article-title":"Chemical and antimicrobial characterization of Mentha piperita L. and Rosmarinus officinalis L. essential oils and in vitro potential cytotoxic effect in human colorectal carcinoma cells","volume":"27","author":"Dolghi","year":"2022","journal-title":"Molecules"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0323804","article-title":"Anticancer potential of Thymoquinone from Nigella sativa L.: an in-silico and cytotoxicity study","volume":"20","author":"Ravi","year":"2025","journal-title":"PloS One"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04617-7","article-title":"Antitumor effects of diosmetin in Ehrlich ascites carcinoma mouse model: insights into ROS-mediated mechanisms","volume":"399","author":"Raza","year":"2025","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117894","article-title":"Synthesis and evaluation of lactam and maleimide derivatives of 16-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide from Polyalthia longifolia as potential anticancer agents","volume":"297","author":"Kumar","year":"2025","journal-title":"Eur J Med Chem"},{"key":"B46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12906-018-2302-x","article-title":"Phytochemical analysis and evaluation of the cytotoxic, antimicrobial and antioxidant activities of essential oils from three Plectranthus species grown in Saudi Arabia","volume":"18","author":"Mothana","year":"2018","journal-title":"BMC Complementary Altern Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142647","article-title":"Analysis of chemical composition and assessment of cytotoxic, antimicrobial, and antioxidant activities of the essential oil of Meriandra dianthera growing in Saudi Arabia","volume":"24","author":"Mothana","year":"2019","journal-title":"Molecules"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010158","article-title":"Anti-migratory and pro-apoptotic properties of parvifloron D on triple-negative breast cancer cells","volume":"10","author":"Saraiva","year":"2020","journal-title":"Biomolecules"},{"key":"B49","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s12032-024-02339-z","article-title":"Evaluation of the cytotoxic activities of the essential oil from Pistacia atlantica Desf. oleoresin on human gastric cancer cell lines","volume":"41","author":"Saeedi","year":"2024","journal-title":"Med Oncol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-024-02065-x","article-title":"Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: In vitro insights and in silico modelling of proapoptotic gene product-compound interactions","volume":"30","author":"Saini","year":"2025","journal-title":"Apoptosis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jep.2014.04.002","article-title":"Chemical composition, antimicrobial activity against Staphylococcus aureus and a pro-apoptotic effect in SGC-7901 of the essential oil from Toona sinensis (A. Juss.) Roem. leaves","volume":"154","author":"Wu","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1955881","article-title":"Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy","volume":"36","author":"Yang","year":"2022","journal-title":"Nat Prod Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"6482","DOI":"10.3390\/ijms26136482","article-title":"Comprehensive phytochemical analysis and evaluation of antioxidant, antimicrobial, cytotoxic, and immunomodulatory activities of commercial cinnamon bark essential oil (Cinnamomum zeylanicum L.)","volume":"26","author":"\u017divkovi\u0107","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2023.100664","article-title":"The anticancer effect of Salvia pisidica essential oil through promotion intrinsic and extrinsic apoptosis pathways in human cancer cell lines","volume":"39","author":"Semiz","year":"2023","journal-title":"J Herb Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.31557\/APJCP.2024.25.4.1457","article-title":"In vitro antiviral and anticancer effects of Tanacetum sinaicum essential oil on human cervical and breast cancer","volume":"25","author":"Sheashea","year":"2024","journal-title":"Asian Pacific J Cancer Prevention: APJCP"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.2174\/1573409920666230831144716","article-title":"Chemical composition, In vitro and in silico evaluation of essential oil from Ocimum tenuiflorum and Coriandrum sativum Linn for lung cancer","volume":"20","author":"Singh","year":"2024","journal-title":"Curr Comput-Aided Drug Des"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142612","article-title":"Extraction, chemical composition, and anticancer potential of Origanum onites L. essential oil","volume":"24","author":"Spyridopoulou","year":"2019","journal-title":"Molecules"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4103\/jrptps.jrptps_37_18","article-title":"In vitro cytobiological effects of phytochemicals from Artemisia turanica","volume":"8","author":"Taherkhani","year":"2019","journal-title":"J Rep Pharm Sci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"107090","DOI":"10.1016\/j.fitote.2026.107090","article-title":"Bioassay-guided isolation and identification of antiproliferative compounds from Acokanthera schimperi (A. DC.) Schweinf and Gnidia involucrata Steudel ex A. rich","volume":"189","author":"Tesfaye","year":"2026","journal-title":"Fitoterapia"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105672","article-title":"Seseli bocconei Guss. and S. tortuosum subsp. maritimum Guss. essential oils inhibit colon cancer cell viability","volume":"170","author":"Vaglica","year":"2023","journal-title":"Fitoterapia"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.3390\/cancers17172839","article-title":"In silico and In vitro evaluation of \u03b4-cadinene from Decatropis bicolor as a selective inhibitor of human cell adhesion and invasion proteins","volume":"17","author":"Reyes-Vidal","year":"2025","journal-title":"Cancers"},{"key":"B62","doi-asserted-by":"publisher","first-page":"20180100","DOI":"10.1515\/jcim-2018-0100","article-title":"Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco","volume":"16","author":"Harassi","year":"2019","journal-title":"J Complementary Integr Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s12032-025-02777-3","article-title":"Developing a formulation of Tinospora cordifolia, identifying its active components, and assessing its anticancer effects on breast cancer cell lines","volume":"42","author":"Muhasina","year":"2025","journal-title":"Med Oncol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30142956","article-title":"Essential oil from the aerial parts of Artemisia serotina Bunge (Winter Wormwood) growing in Kazakhstan-phytochemical profile and bioactivity","volume":"30","author":"Kadyrbay","year":"2025","journal-title":"Molecules"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2848736","DOI":"10.1155\/2024\/2848736","article-title":"Chemical composition and in vitro and in silico biological activities of Myrciaria tenella (DC.) O. Berg (Myrtaceae) essential oil from Brazil","volume":"2024","author":"Ferreira","year":"2024","journal-title":"J Food Biochem"},{"key":"B66","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12906-023-03892-2","article-title":"Heracleum persicum Desf. ex Fisch. CA Mey. & Av\u00e9-Lall. fruit essential oil: content, antimicrobial activity and cytotoxicity against ovarian cancer cell line","volume":"23","author":"Ghavam","year":"2023","journal-title":"BMC Complementary Med Ther"},{"key":"B67","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12906-016-1136-7","article-title":"Decatropis bicolor (Zucc.) Radlk essential oil induces apoptosis of the MDA-MB-231 breast cancer cell line","volume":"16","author":"Estanislao G\u00f3mez","year":"2016","journal-title":"BMC Complementary Altern Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/molecules31010046","article-title":"Evaluation of Cedrus atlantica essential oil: chemical composition, anticancer activity and molecular docking studies","volume":"31","author":"Gruin","year":"2025","journal-title":"Molecules"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112405","article-title":"Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL\/Apo2L-induced HCT-116 cell death","volume":"136","author":"Guesmi","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29225431","article-title":"Evaluation of antiproliferative potentials associated with the volatile compounds of Lantana camara flowers: selective in vitro activity","volume":"29","author":"El Hajj","year":"2024","journal-title":"Molecules"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104266","article-title":"Sesquiterpene rich essential oil from Nepalese Bael tree (Aegle marmelos (L.) Correa) as potential antiproliferative agent","volume":"138","author":"Pant","year":"2019","journal-title":"Fitoterapia"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2024.2320350","article-title":"Impact of hydrodistillation and steam distillation on the yield and chemical composition of essential oils and their comparison with modern isolation techniques","volume":"36","author":"Pheko-Ofitlhile","year":"2024","journal-title":"J Essent Oil Res"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-025-10123-8","article-title":"Essential oils and plant-derived bioactive compounds: a comprehensive review of their therapeutic potential, mechanisms of action, and advances in extraction technologies","volume":"25","author":"Ali","year":"2026","journal-title":"Phytochem Rev"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/molecules31071202","article-title":"Solvent-based extraction recovers phytochemicals from medicinal plants demonstrating anticancer and chemopreventive potential: a review","volume":"31","author":"Ojong","year":"2026","journal-title":"Molecules"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/plants11212886","article-title":"Bioassay guided fractionation protocol for determining novel active compounds in selected Australian flora","volume":"11","author":"Mani","year":"2022","journal-title":"Plants"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2024.100676","article-title":"Bioassay-guided isolation and identification of antimutagenic compounds from Morina coulteriana and evaluation of its therapeutic potential","volume":"5","author":"Kour","year":"2025","journal-title":"Phytomed Plus"},{"key":"B77","doi-asserted-by":"publisher","first-page":"10528","DOI":"10.3390\/ijms231810528","article-title":"\u03b1-Bisabolol attenuates doxorubicin induced renal toxicity by modulating NF-\u03baB\/MAPK signaling and caspase-dependent apoptosis in rats","volume":"23","author":"Arunachalam","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1924878\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:32:20Z","timestamp":1787891540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1924878\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":77,"alternative-id":["10.3389\/fonc.2026.1924878"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1924878","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"article-number":"1924878"}}