{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:10:16Z","timestamp":1789017016193,"version":"build-2803163510"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      T-cell acute lymphoblastic leukemia (T-ALL) with\n                      <jats:italic>ABL1<\/jats:italic>\n                      rearrangement is an extremely rare disease, and its clinical significance has not been precisely defined. We report the clinical characteristics of a pediatric patient with T-cell acute lymphoblastic leukemia harboring\n                      <jats:italic>ABL1<\/jats:italic>\n                      rearrangement and the treatment response to tyrosine kinase inhibitor (TKI) therapy, providing a reference for clinical management with this subtype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case reports<\/jats:title>\n                    <jats:p>\n                      A 3-year-old boy with T-ALL and\n                      <jats:italic>ZBTB16::ABL1<\/jats:italic>\n                      fusion (RNA-seq) showed poor response to induction chemotherapy, failing remission at D33. Dasatinib (75 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/day) was added concurrently with CAM chemotherapy. At D90, morphological CR and flow-MRD negativity were achieved, though qPCR remained positive at 0.08%. Isolated CNS relapse occurred during Block III consolidation. Subsequent management included autologous CD7 CAR T-cell therapy and allogeneic HSCT; post-transplant evaluation confirmed sustained leukemia remission. However, the patient developed HHV-6 encephalitis and adenovirus hepatitis with hepatic failure; life-sustaining support was withdrawn at the family\u2019s request. The patient was discharged and lost to follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This paper presents the second reported case to date of TKI treatment for T-cell acute lymphoblastic leukemia harboring the\n                      <jats:italic>ZBTB16::ABL1<\/jats:italic>\n                      fusion. Following a review of the relevant literature on\n                      <jats:italic>ABL1<\/jats:italic>\n                      -rearranged T-ALL, we conclude that the accumulation of additional cases is essential to better characterize this rare molecular subtype and to guide evidence-based treatment decisions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1928646","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:32:41Z","timestamp":1789014761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Clinical response to TKI therapy in T-cell acute lymphoblastic leukemia with rare ABL1 rearrangement"],"prefix":"10.3389","volume":"16","author":[{"given":"Mingyan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Paediatric Hematology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Physical Examination and Health Management, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingji","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical 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