{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:09:36Z","timestamp":1793426976913,"version":"4.5.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The C-reactive protein-to-lymphocyte ratio (CLR), a novel inflammation-based biomarker, has been reported to be associated with prognosis in various cancers. However, the prognostic significance of CLR remains controversial. Therefore, we performed a meta-analysis to comprehensively evaluate the prognostic value of CLR in patients with cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant studies were systematically searched in PubMed, Embase, and Web of Science up to March 21, 2026. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to assess the association between CLR and survival outcomes, including overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 22 studies from 18 articles involving 7220 patients were included. The pooled analysis demonstrated that elevated CLR was significantly associated with poorer OS (HR:1.65, 95% CI: 1.43-1.91), PFS (HR:1.53, 95% CI: 1.15-2.05), and DFS (HR:1.67, 95% CI: 1.41-1.97). Subgroup analysis further confirmed the prognostic value of CLR across country, treatment method, sample size, cancer type and analysis type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated CLR was significantly associated with unfavorable survival outcomes in cancers and may serve as a promising prognostic biomarker in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1932997","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:22:54Z","timestamp":1787286174000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of the C-reactive protein-to-lymphocyte ratio in patients with 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