{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:48Z","timestamp":1789448568529,"version":"build-2803163510"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oncoplastic breast-conserving surgery (OBCS) may permit wider excision within a breast-conserving approach, but its effects on margin control and subsequent surgery remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed\/MEDLINE, Embase, Web of Science Core Collection, Scopus, and the Cochrane Library from inception through 25 June 2026 for comparative studies of OBCS versus conventional breast-conserving surgery (BCS). Primary outcomes were initial positive margin, re-excision, completion\/conversion mastectomy, and any margin-related reoperation. Secondary outcomes were negative\/clear margin, recurrence, and complications. Risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random-effects Mantel\u2013Haenszel models. Methodological quality was assessed using the Newcastle\u2013Ottawa Scale. The protocol was registered in PROSPERO (CRD420261439265).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-eight comparative studies comprising 124,903 BCS observations were included (28,085 OBCS; 96,818 conventional BCS). Compared with conventional BCS, OBCS was associated with lower risks of initial positive margin (RR 0.57, 95% CI 0.40\u20130.80), re-excision (RR 0.59, 95% CI 0.46\u20130.77), completion\/conversion mastectomy (RR 0.62, 95% CI 0.43\u20130.90), and any margin-related reoperation (RR 0.63, 95% CI 0.51\u20130.78). OBCS was also associated with a higher likelihood of achieving negative\/clear margins (RR 1.07, 95% CI 1.04\u20131.11). No significant between-group differences were observed in local recurrence\/ipsilateral breast tumor recurrence or locoregional recurrence. Overall complication risk was higher in the primary analysis, but the association was attenuated to borderline statistical significance after exclusion of registry or administrative-database cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OBCS was associated with more favorable margin-related outcomes and fewer margin-driven reoperations, without a detectable increase in recurrence. These findings support selective use of OBCS as a margin-control and breast-preservation strategy in appropriately selected patients. However, complication estimates should be interpreted cautiously because reporting and ascertainment varied across study designs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420261439265<\/jats:ext-link>\n                      , identifier CRD420261439265.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1934279","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:26:11Z","timestamp":1789446371000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Margin status, re-excision, and completion mastectomy after oncoplastic versus conventional breast-conserving surgery for breast cancer: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Na","family":"Hou","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Jiande","place":["Jiande, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Jiande","place":["Jiande, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Jiande","place":["Jiande, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Jiande","place":["Jiande, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Jiande","place":["Jiande, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.2212","article-title":"Bilateral mastectomy and breast cancer mortality","volume":"10","author":"Giannakeas","year":"2024","journal-title":"JAMA Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials","volume":"378","author":"Darby","year":"2011","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.3935","article-title":"Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer","volume":"32","author":"Moran","year":"2014","journal-title":"J Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.3573","article-title":"Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in ductal carcinoma in situ","volume":"34","author":"Morrow","year":"2016","journal-title":"J Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.3025","article-title":"Changes in reoperation after publication of consensus guidelines on margins for breast-conserving surgery: a systematic review and meta-analysis","volume":"155","author":"Marinovich","year":"2020","journal-title":"JAMA Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-14902-z","article-title":"Contemporary analysis of reexcision and conversion to mastectomy rates and associated healthcare costs for women undergoing breast-conserving surgery","volume":"31","author":"Kim","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504473","article-title":"A randomized, controlled trial of cavity shave margins in breast cancer","volume":"373","author":"Chagpar","year":"2015","journal-title":"N Engl J Med"},{"key":"B9","article-title":"Applicability of oncoplastic breast conserving surgery in Asian breast cancer patients","volume":"17","author":"Lim","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013658.pub2","article-title":"Oncoplastic breast-conserving surgery for women with primary breast cancer","volume":"10","author":"Nanda","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"B11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.breast.2021.02.013","article-title":"Should oncoplastic breast conserving surgery be used for the treatment of early stage breast cancer? Using the GRADE approach for development of clinical recommendations","volume":"57","author":"Rocco","year":"2021","journal-title":"Breast"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae306","article-title":"Clinical and patient-reported outcomes in women offered oncoplastic breast-conserving surgery as an alternative to mastectomy: ANTHEM multicentre prospective cohort study","volume":"112","author":"Davies","year":"2024","journal-title":"Br J Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae310","article-title":"Clinical and patient-reported outcomes after oncoplastic vs conventional breast-conserving surgery-a longitudinal, multicenter cohort study","volume":"117","author":"Bargon","year":"2025","journal-title":"J Natl Cancer Inst"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11838","article-title":"Rates of re-excision and conversion to mastectomy after breast-conserving surgery with or without oncoplastic surgery: a nationwide population-based study","volume":"107","author":"Heeg","year":"2020","journal-title":"Br J Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"B16","unstructured":"Higgins\n              JPT\n            \n            \n              Thomas\n              J\n            \n            \n              Chandler\n              J\n            \n          \n          Chichester\n          Cochrane\n          Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (Updated February 2022)\n          \n          2022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4103\/ejs.ejs_182_23","article-title":"Comparison between conventional and oncoplastic breast surgeries regarding resection margins and local recurrences in breast cancer: retrospective study","volume":"42","author":"Ahmed","year":"2023","journal-title":"Egyptian J Surg"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102618","article-title":"Oncoplastic surgery: A suitable alternative to conventional breast conserving surgery in low - Middle income countries; a retrospective cohort study","volume":"68","author":"Sakina Abidi","year":"2021","journal-title":"Ann Med Surg (Lond)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpra.2021.05.010","article-title":"Comparative study of surgical and oncological outcomes in oncoplastic versus non oncoplastic breast-conserving surgery for breast cancer treatment","volume":"29","author":"Almeida","year":"2021","journal-title":"JPRAS Open"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000007638","article-title":"Oncoplastic versus standard breast-conserving surgery: predictors of re-excision, complications, and safety outcomes","volume":"14","author":"Almojel","year":"2026","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zraa013","article-title":"Recurrence and survival after standard versus oncoplastic breast-conserving surgery for breast cancer","volume":"5","author":"Andr\u00e9","year":"2021","journal-title":"BJS Open"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0280","article-title":"Oncoplastic breast-conservative surgery for breast cancers: a uni-institutional case-control study","volume":"17","author":"Atallah","year":"2021","journal-title":"Future Oncol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S560836","article-title":"Oncoplastic or conventional breast-conserving surgery? Outcomes from a West Java retrospective cohort study","volume":"17","author":"Azhar","year":"2025","journal-title":"Int J Womens Health"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2018.06.004","article-title":"Wide local excision versus oncoplastic breast surgery: differences in surgical outcome for an assumed margin (0, 1, or 2 mm) distance","volume":"18","author":"Bali","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15245","article-title":"Oncoplastic breast surgery versus conventional breast-conserving surgery: a comparative retrospective study","volume":"89","author":"Behluli","year":"2019","journal-title":"Anz J Surg"},{"key":"B26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s00238-024-02160-x","article-title":"Comparison between breast conserving therapy and oncoplastic reduction mammaplasty: a retrospective study","volume":"47","author":"Caixeiro","year":"2024","journal-title":"Eur J Plast Surg"},{"key":"B27","article-title":"Comparative study of oncoplastic versus non-oncoplastic breast conserving surgery in a group of 211 breast cancer patients","volume":"20","author":"Cal\u00ec Cassi","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B28","article-title":"Feasibility of oncoplastic surgery in breast cancer patients with associated in situ carcinoma","volume":"26","author":"Caziuc","year":"2021","journal-title":"J Buon"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-025-01786-4","article-title":"Comparative analysis of level II oncoplastic surgery and conventional breast-conserving surgery in breast cancer with a ductal carcinoma in situ component","volume":"33","author":"\u00c7elik","year":"2026","journal-title":"Breast Cancer"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.02.186","article-title":"How safe is oncoplastic breast conservation? Comparative analysis with standard breast conserving surgery","volume":"38","author":"Chakravorty","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2015.11.001","article-title":"Evaluation of surgical outcomes following oncoplastic breast surgery in early breast cancer and comparison with conventional breast conservation surgery","volume":"72","author":"Chauhan","year":"2016","journal-title":"Med J Armed Forces India"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0549-6","article-title":"Evaluation of surgical outcomes of oncoplasty breast surgery in locally advanced breast cancer and comparison with conventional breast conservation surgery","volume":"7","author":"Chauhan","year":"2016","journal-title":"Indian J Surg Oncol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4738-2","article-title":"Oncoplastic breast-conserving surgery reduces mastectomy and postoperative re-excision rates","volume":"22","author":"Crown","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"B34","article-title":"Breast parenchymal density: does it affect oncological and surgical outcomes in conventional lumpectomy and oncoplastic surgery","volume":"93","author":"Culcu","year":"2022","journal-title":"Ann Ital Chir"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.04.015","article-title":"Oncoplastic breast surgery for the management of ductal carcinoma in situ (DCIS): is it oncologically safe? A retrospective cohort analysis","volume":"44","author":"De Lorenzi","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.10.027","article-title":"Standard wide local excision or bilateral reduction mammoplasty in large-breasted women with small tumours: surgical and patient-reported outcomes","volume":"43","author":"Di Micco","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/tbj.12047","article-title":"Oncological advantages of oncoplastic breast-conserving surgery in treatment of early breast cancer","volume":"19","author":"Down","year":"2013","journal-title":"Breast J"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-15326-5","article-title":"Oncologic safety of immediate oncoplastic surgery compared with standard breast-conserving surgery for patients with invasive lobular carcinoma","volume":"31","author":"Falade","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16222","article-title":"Achieving margin clearance following oncoplastic breast surgery in comparison with simple wide local excision: a three-dimensional specimen assessment","volume":"90","author":"Garreffa","year":"2020","journal-title":"Anz J Surg"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9098-5","article-title":"Comparative study of the accuracy of breast resection in oncoplastic surgery and quadrantectomy in breast cancer","volume":"14","author":"Giacalone","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2013.16.2.193","article-title":"Comparison of outcomes of standard and oncoplastic breast-conserving surgery","volume":"16","author":"Gulcelik","year":"2013","journal-title":"J Breast Cancer"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.12.046","article-title":"Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer","volume":"12","author":"Kaur","year":"2005","journal-title":"Ann Surg Oncol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.09.006","article-title":"Comparison of clinicopathologic, cosmetic and quality of life outcomes in 700 oncoplastic and conventional breast-conserving surgery cases: a single-centre retrospective study","volume":"45","author":"Kelemen","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2023.10.134","article-title":"Oncoplastic breast reduction surgery decreases rates of reoperation with no increased medical risk","volume":"88","author":"Kilmer","year":"2024","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.soi.2026.100239","article-title":"Survival outcomes after standard breast conserving surgery versus oncoplastic breast conserving surgery in breast cancer patients: a multicenter real-world evidence cohort study","volume":"3","author":"Lima","year":"2026","journal-title":"Surg Oncol Insight"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.03.06","article-title":"Oncoplastic round block technique has comparable operative parameters as standard wide local excision: a matched case-control study","volume":"6","author":"Lim","year":"2017","journal-title":"Gland Surg"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol33030163","article-title":"Oncoplastic surgery versus lumpectomy: analysis of oncological outcomes and surgical complications in 1290 breast cancer patients","volume":"33","author":"Lopez Rios","year":"2026","journal-title":"Curr Oncol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6682-4","article-title":"Breast conservation and negative margins in invasive lobular carcinoma: the impact of oncoplastic surgery and shave margins in 358 patients","volume":"25","author":"Mukhtar","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.21037\/gs-24-385","article-title":"Cohort study comparing volume replacement oncoplastic breast surgery with standard wide local excision for breast cancer","volume":"14","author":"Nanda","year":"2025","journal-title":"Gland Surg"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.02.010","article-title":"Resection margins and local recurrences in breast cancer: comparison between conventional and oncoplastic breast conserving surgery","volume":"45","author":"Niinikoski","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.5812\/ijcm.9696","article-title":"Comparison of surgical margin after breast cancer surgery between oncoplastic technique and conventional breast-conserving surgery","volume":"11","author":"Nisiri","year":"2018","journal-title":"Int J Cancer Manag"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2021.24.e52","article-title":"Comparison of long-term oncological outcomes in oncoplastic breast surgery and conventional breast-conserving surgery for breast cancer: A propensity score-matched analysis","volume":"24","author":"Oh","year":"2021","journal-title":"J Breast Cancer"},{"key":"B53","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.clbc.2019.05.016","article-title":"Oncoplastic breast surgery compared to conventional breast-conserving surgery with regard to oncologic outcome","volume":"19","author":"Rose","year":"2019","journal-title":"Clin Breast Cancer"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2021.56","article-title":"Comparison of oncoplastic breast surgery, non-oncoplastic breast conserving surgery and mastectomy in early breast cancer: A single center retrospective study","volume":"24","author":"Sagiroglu","year":"2021","journal-title":"Arch Iran Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-024-04043-8","article-title":"A randomised controlled trial evaluating the aesthetic outcomes of oncoplasty vs. simple closure and 1- vs. 2-cm excision margin for early breast cancer","volume":"86","author":"Saha","year":"2024","journal-title":"Indian J Surg"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003313","article-title":"The impact of oncoplastic reduction on initiation of adjuvant radiation and need for reexcision: A database evaluation","volume":"89","author":"Shah","year":"2022","journal-title":"Ann Plast Surg"},{"key":"B57","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.amjsurg.2013.09.017","article-title":"Surgical, oncologic, and cosmetic differences between oncoplastic and nononcoplastic breast conserving surgery in breast cancer patients","volume":"207","author":"Tenofsky","year":"2014","journal-title":"Am J Surg"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2021.06.005","article-title":"A comparison of the oncological outcomes after breast-conserving surgery with or without latissimus dorsi myocutaneous flap reconstruction for breast cancer","volume":"22","author":"Tokui","year":"2022","journal-title":"Clin Breast Cancer"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2016.08.001","article-title":"The role of oncoplastic breast conserving treatment for locally advanced breast tumors. A matching case-control study","volume":"10","author":"Vieira","year":"2016","journal-title":"Ann Med Surg (Lond)"},{"key":"B60","doi-asserted-by":"publisher","first-page":"8","DOI":"10.12669\/pjms.40.1.7360","article-title":"Outcomes of oncoplastic breast surgery compared to breast-conserving surgery in breast cancer patients in a developing country: A retrospective cohort study","volume":"40","author":"Vohra","year":"2024","journal-title":"Pak J Med Sci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12893-023-02182-5","article-title":"Oncoplastic breast conserving surgery versus standard breast conserving surgery for early and locally advanced breast cancer: A retrospective analysis from Sri Lanka","volume":"23","author":"Wijesinghe","year":"2023","journal-title":"BMC Surg"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.21037\/gs-23-371","article-title":"Expanded indications for breast-conserving surgery with oncoplastic approaches compared to conventional approaches: A single-center retrospective comparative cohort study","volume":"12","author":"Zhou","year":"2023","journal-title":"Gland Surg"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07345-4","article-title":"A consensus definition and classification system of oncoplastic surgery developed by the American Society of Breast Surgeons","volume":"26","author":"Chatterjee","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002439","article-title":"Ductal carcinoma in situ and margins <2\u200amm: Contemporary outcomes with breast conservation","volume":"269","author":"Tadros","year":"2019","journal-title":"Ann Surg"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070346","article-title":"Margin status and survival outcomes after breast cancer conservation surgery: Prospectively registered systematic review and meta-analysis","volume":"378","author":"Bundred","year":"2022","journal-title":"BMJ"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.2661","article-title":"Beyond the margins-economic costs and complications associated with repeated breast-conserving surgeries","volume":"152","author":"Metcalfe","year":"2017","journal-title":"JAMA Surg"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3920","article-title":"Definition, reporting, and interpretation of composite outcomes in clinical trials: Systematic review","volume":"341","author":"Cordoba","year":"2010","journal-title":"BMJ"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2024.103784","article-title":"Efficacy and safety of oncoplastic breast-conserving surgery versus conventional breast-conserving surgery: An updated meta-analysis","volume":"77","author":"Tian","year":"2024","journal-title":"Breast"},{"key":"B69","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S1470-2045(14)71156-8","article-title":"Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial","volume":"16","author":"Bartelink","year":"2015","journal-title":"Lancet Oncol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2023.103584","article-title":"The King is in the altogether: Radiation therapy after oncoplastic breast surgery","volume":"72","author":"Kaidar-Person","year":"2023","journal-title":"Breast"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07592-5","article-title":"An oncoplastic surgery primer: Common indications, techniques, and complications in level 1 and 2 volume displacement oncoplastic surgery","volume":"26","author":"Patel","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005355","article-title":"Oncoplastic breast reduction: A systematic review of postoperative complications","volume":"11","author":"Benedict","year":"2023","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PloS Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.04.005","article-title":"Delay of adjuvant radiotherapy due to postoperative complications after oncoplastic breast conserving surgery","volume":"39","author":"Hillberg","year":"2018","journal-title":"Breast"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006010","article-title":"Complications after oncoplastic breast reduction and impact on time to adjuvant therapy","volume":"12","author":"Moen","year":"2024","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.05.006","article-title":"Oncoplastic breast surgery: A guide to good practice","volume":"47","author":"Gilmour","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3747\/co.27.5977","article-title":"Consensus statement on tumour bed localization for radiation after oncoplastic breast surgery","volume":"27","author":"Tse","year":"2020","journal-title":"Curr Oncol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5313-1","article-title":"Outcomes after oncoplastic breast-conserving surgery in breast cancer patients: A systematic literature review","volume":"23","author":"De La Cruz","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2022.101779","article-title":"Comparison of surgical and oncological outcomes between oncoplastic breast-conserving surgery versus conventional breast-conserving surgery for treatment of breast cancer: A systematic review and meta-analysis of 31 studies","volume":"42","author":"Mohamedahmed","year":"2022","journal-title":"Surg Oncol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-08195-w","article-title":"Development and validation of the BREAST-Q breast-conserving therapy module","volume":"27","author":"Klassen","year":"2020","journal-title":"Ann Surg Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1934279\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:26:15Z","timestamp":1789446375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1934279\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":80,"alternative-id":["10.3389\/fonc.2026.1934279"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1934279","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"article-number":"1934279"}}