{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:16:15Z","timestamp":1788498975695,"version":"build-2803163510"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paraneoplastic syndromes (PNS) are frequently associated with thymoma. The unusual clustering of myasthenia gravis, dysgeusia, and AIPO during thymoma recurrence has been sparsely reported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a man who developed pleural metastasis three years after thymoma resection and shortly thereafter experienced dysgeusia, ocular MG (diplopia and ophthalmoplegia), and AIPO. This triad has received limited documentation. Serum testing was positive for acetylcholine receptor antibody (AChR-Ab), anti-MURC antibody, and anti-recoverin antibody. After combined CAP chemotherapy and symptomatic pyridostigmine therapy, the pleural lesions regressed, and the ocular, taste, and gastrointestinal symptoms also resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates that multisystem PNS can arise years after thymectomy and may cluster, emphasizing the need for early recognition and multidisciplinary, comprehensive management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1937358","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:26:51Z","timestamp":1788496011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Recurrent metastatic thymoma-associated multiple paraneoplastic syndromes: myasthenia gravis, dysgeusia, and acute intestinal pseudo-obstruction"],"prefix":"10.3389","volume":"16","author":[{"given":"Yunlong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jtcvs.2019.11.052","article-title":"A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases","volume":"160","author":"Zhao","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2019-thym-10","article-title":"Autoimmune disorders and paraneoplastic syndromes in thymoma","volume":"12","author":"Blum","year":"2020","journal-title":"J Thorac Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.21037\/med-25-28","article-title":"Pathogenesis of thymoma-associated myasthenia gravis: a narrative review","volume":"9","author":"Okuno","year":"2025","journal-title":"Mediastinum"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0429-z","article-title":"Paraneoplastic diseases associated with thymoma","volume":"254","author":"Evoli","year":"2007","journal-title":"J Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/s12883-025-04407-x","article-title":"Myasthenia gravis complicated by intestinal pseudo-obstruction: a case report and literature review","volume":"25","author":"Lin","year":"2025","journal-title":"BMC Neurol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00214","article-title":"Myasthenia gravis with thymoma, manifesting as AChR-Ab-positive, distinct bulbar palsy accompanied by dysgeusia: a case series and review of literature","volume":"9","author":"Zhu","year":"2018","journal-title":"Front Neurol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.21037\/med-23-8","article-title":"Immunosuppressive treatment for myasthenia gravis crises improve the taste disorder in patients with thymoma: Two case reports","volume":"7","author":"Fukumoto","year":"2023","journal-title":"Mediastinum"},{"key":"B8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12883-024-03644-w","article-title":"Taste disorders and alopecia in myasthenia gravis","volume":"24","author":"Uzawa","year":"2024","journal-title":"BMC Neurol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.47.4.985","article-title":"Intestinal pseudo-obstruction, myasthenia gravis, and thymoma","volume":"47","author":"Anderson","year":"1996","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00262-026-04311-4","article-title":"Thymic epithelial tumors at the crossroads of immunity, autoimmunity, and immunotherapy","volume":"75","author":"Canaslan","year":"2026","journal-title":"Cancer Immunol Immunother"},{"key":"B11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41572-019-0079-y","article-title":"Myasthenia gravis","volume":"5","author":"Gilhus","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2022.63","article-title":"Gastrointestinal dysmotility as the first manifestation of myasthenia gravis","volume":"50","author":"Alnajjar","year":"2023","journal-title":"Can J Neurol Sci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-023-00881-w","article-title":"Update on the diagnosis and management of acute colonic pseudo-obstruction (ACPO)","volume":"25","author":"Sen","year":"2023","journal-title":"Curr Gastroenterol Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.729075","article-title":"CRMP5 antibodies\u2014Diagnostic challenges","volume":"12","author":"Totland","year":"2021","journal-title":"Front Neurol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10577-8","article-title":"Paraneoplastic vs. non-paraneoplastic anti-Hu associated dysmotility: a case series and literature review","volume":"269","author":"Rossi","year":"2022","journal-title":"J Neurol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70309","article-title":"Beyond the surface: Investigating the potential mechanisms of non-motor symptoms in myasthenia gravis","volume":"32","author":"Wang","year":"2025","journal-title":"Eur J Neurol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2026.101204","article-title":"Correlation between antiretinal antibodies and OCT manifestations in nonparaneoplastic autoimmune retinopathy","volume":"6","author":"Xu","year":"2026","journal-title":"Ophthalmol Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.21037\/med-21-28","article-title":"Taste disorder in a patient with invasive thymoma without myasthenia gravis: A rare case report","volume":"6","author":"Kosaka","year":"2022","journal-title":"Mediastinum"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/jci143771","article-title":"Gastrointestinal motility disorders in neurologic disease","volume":"131","author":"Camilleri","year":"2021","journal-title":"J Clin Invest"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1937358\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:26:53Z","timestamp":1788496013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1937358\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":19,"alternative-id":["10.3389\/fonc.2026.1937358"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1937358","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"article-number":"1937358"}}