{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:58:20Z","timestamp":1790657900921,"version":"4.1.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Lipoblastoma-like tumor (LLT) is a distinctive adipocytic neoplasm most commonly arising in the vulva of women. Lingual involvement is extremely rare. Herein, we present a case of LLT occurring in the tongue and review the relevant literature. The patient was a 41-year-old female who presented with a mass on the right lateral border of the tongue for 6 months. Microscopic examination revealed the typical features of LLT. Immunohistochemically, the tumor was positive for CD34 and vimentin, with partial positivity for CDK4 and S-100, and negative for Rb, p16, and MDM2. Fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) demonstrated no DDIT3 rearrangement or MDM2 amplification. Next-generation sequencing (NGS) detected no significant genetic alterations. The tumor was completely resected, and no recurrence was observed at 19 months of follow-up. Given the rarity of lingual LLT\u2014of which only three cases, including ours, have been reported\u2014this report expands the current knowledge base and emphasizes the need for accurate diagnosis and long-term patient surveillance.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1941099","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:34:24Z","timestamp":1790656464000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: lipoblastoma-like tumor of the tongue"],"prefix":"10.3389","volume":"16","author":[{"given":"Li","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Pathology, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01392.x","article-title":"Lipoblastoma-like tumour of the vulva: report of three cases of a distinctive mesenchymal neoplasm of adipocytic differentiation","volume":"40","author":"Lae","year":"2002","journal-title":"Histopathology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000469","article-title":"Lipoblastoma-like tumor of the vulva: further characterization in 8 new cases","volume":"39","author":"Mirkovic","year":"2015","journal-title":"Am J Surg 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deletion","volume":"17","author":"Sugita","year":"2025","journal-title":"Cureus"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0923","article-title":"Lipoblastoma-like tumour of the lip in an adult woman","volume":"90","author":"Jeong","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/ors.12996","article-title":"Lipoma of the buccal fat pad: systematic review and report of a case","volume":"19","author":"D'Agostino","year":"2026","journal-title":"Oral Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0102-y","article-title":"Lipoblastoma-like tumor of the vulva: a clinicopathologic, immunohistochemical, fluorescence in situ hybridization and genomic copy number profiling study of seven cases","volume":"31","author":"Schoolmeester","year":"2018","journal-title":"Mod 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Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1941099\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:34:48Z","timestamp":1790656488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1941099\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":13,"alternative-id":["10.3389\/fonc.2026.1941099"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1941099","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"1941099"}}