{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:01:09Z","timestamp":1790744469554,"version":"4.1.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary adrenal malignant rhabdoid tumor (MRT) is a rare, highly aggressive neoplasm lacking specific clinical manifestations and imaging characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case report delineates the clinical course of a patient with primary adrenal MRT managed at our institution. We provide a comprehensive characterization of the patient\u2019s clinical presentation, histopathological and molecular genetic profiles, and the therapeutic strategy employed. Furthermore, we critically examine contemporary evidence regarding its pathogenesis, diagnostic challenges, and therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 42-year-old man was initially admitted to the Department of Endocrinology presenting with pyrexia and an adrenal mass. The patient underwent surgical resection of an adrenal mass; definitive histopathological examination and molecular genetic profiling confirmed a diagnosis of primary adrenal MRT. Despite undergoing surgical resection and adjuvant chemotherapy, the patient ultimately succumbed to sudden cardiac death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Primary adrenal MRT represent an exceptionally rare clinical entity. Consequently, clinicians must maintain high suspicion for this diagnosis when evaluating non-functioning adrenal masses, especially those with atypical radiological features or aggressive behavior.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1971354","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:46:27Z","timestamp":1790743587000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report: A rare primary adrenal malignant rhabdoid tumor in a 42-year-old man"],"prefix":"10.3389","volume":"16","author":[{"given":"Jiali","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengya","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.240015","article-title":"Malignant rhabdoid tumor and related pediatric tumors: multimodality imaging review with pathologic correlation","volume":"44","author":"Lorca","year":"2024","journal-title":"RadioGraphics"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969211024331","article-title":"Primary adrenal malignant rhabdoid tumor in a 14-year-old female: a case report and literature review","volume":"30","author":"Alturkustani","year":"2022","journal-title":"Int J Surg Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.31487\/j.ACO.2019.02.02","article-title":"Malignant rhabdoid tumor of the adrenal gland: case report and review of the literature","volume":"2","author":"Al-Daghmin","year":"2019","journal-title":"Ann Clin Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3348\/jksr.2014.71.1.20","article-title":"Malignant extrarenal rhabdoid tumor in adults: three case reports originating from the ileum, adrenal gland and uterus","volume":"71","author":"Shim","year":"2014","journal-title":"J Korean Soc Radiol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10059","article-title":"Malignant rhabdoid tumor of adrenal gland","volume":"39","author":"Yaris","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000141390.14548.34","article-title":"Immunohistochemical analysis of hSNF5\/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors","volume":"28","author":"Hoot","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0357-3","article-title":"The SWI\/SNF complex in cancer - 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