{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:10:50Z","timestamp":1792649450285,"version":"4.5.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ophthalmic outcomes following venous sinus stenting (VSS) in patients with idiopathic intracranial hypertension (IIH) are not well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted on 86 consecutive patients with IIH who underwent venous sinus stenting at Mayo Clinic, Rochester, Minnesota and Stanford Medical Center, Palo Alto, California between May 2015 and October 2021. Patients with raised intracranial pressure from a non-IIH etiology were excluded. Clinical symptoms and neuro-ophthalmological data, including best corrected visual acuity (BCVA), visual field mean deviation, papilledema, and optical coherence tomography (OCT) peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell inner plexiform layer (GC-IPL), were analyzed. Baseline measurements before VSS and 3 months or more postoperatively were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-six subjects (82 female) were included in this study, with a median age of 33 (16\u201368) years and a median body mass index of 36.69 (22.30\u201362.00) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . 85\/86 (98.8%) had attempted prior management with medication, and 12\/86 (14%) had prior surgical management with optic nerve sheath fenestration, ventriculoperitoneal shunt, or bariatric surgery. Prior to VSS, 67\/86 (77.9%) had papilledema, 85\/86 (98.8%) had headaches, and 68\/86 (79.1%) had pulsatile tinnitus. For patients with both pre- and post-VSS data available, the average papilledema grade was 1.76 (0\u20135) (n = 74) and the average OCT pRNFL was 186.34 (52.00\u2013588.00) \u00b5m (n = 70), prior to VSS. A median of 4.0 (interquartile range 3.3\u20135.4) months after VSS, the average papilledema grade improved to 0.39 (0\u20132),\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;0.001, and OCT pRNFL improved to 96.86 (47.00\u2013168.00) \u00b5m,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;0.001. 28\/86 (32.6%) patients no longer required medication for high intracranial pressure. 14\/85 (16.5%) patients reported complete resolution of their headache and 55\/71 (77.5%) reported improvement in headache quality. 40\/68 (66.7%) reported complete resolution of pulsatile tinnitus. OCT GC-IPL, BCVA, and visual field mean deviation did not significantly change pre- vs post-VSS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our large consecutive case series corroborates smaller prior studies in demonstrating the overall efficacy of VSS for patients with IIH. We found both ophthalmic improvements, as demonstrated by the significantly reduced papilledema and pRNFL, and overall clinical symptom improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fopht.2022.910524","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T03:59:09Z","timestamp":1656561549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Improved Ophthalmic Outcomes Following Venous Sinus Stenting in Idiopathic Intracranial Hypertension"],"prefix":"10.3389","volume":"2","author":[{"given":"Kafayat A.","family":"Oyemade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy T.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Brinjikji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy K.","family":"Cutsforth-Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Kallmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u00a0Tariq","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1001\/archneur.1993.00540010072020","article-title":"Idiopathic Intracranial Hypertension (Pseudotumor Cerebri): Descriptive Epidemiology in Rochester, Minn, 1976 to 1990","volume":"50","author":"Radhakrishnan","year":"1993","journal-title":"Arch Neurol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320065016","article-title":"The Incidence of Pseudotumor Cerebri: Population Studies in Iowa and Louisiana","volume":"45","author":"Durcan","year":"1988","journal-title":"Arch Neurol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.6625","article-title":"Etiology of Papilledema in Patients in the Eye Clinic Setting","volume":"3","author":"Crum","year":"2020","journal-title":"JAMA Netw Open"},{"key":"B4","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.ophtha.2017.01.006","article-title":"Re-Evaluating the Incidence of Idiopathic Intracranial Hypertension in an Era of Increasing Obesity","volume":"124","author":"Kilgore","year":"2017","journal-title":"Ophthalmology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16450","article-title":"Causes and Prognosis of Visual Acuity Loss at the Time of Initial Presentation in Idiopathic Intracranial Hypertension","volume":"56","author":"Chen","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510200003001","article-title":"Visual Loss in Pseudotumor Cerebri. Follow-Up of 57 Patients From Five to 41 Years and a Profile of 14 Patients With Permanent Severe Visual Loss","volume":"39","author":"Corbett","year":"1982","journal-title":"Arch Neurol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/jamaneurol.2014.133","article-title":"The Idiopathic Intracranial Hypertension Treatment Trial: Clinical Profile at Baseline","volume":"71","author":"Wall","year":"2014","journal-title":"JAMA Neurol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1136\/jnnp-2017-317440","article-title":"Idiopathic Intracranial Hypertension: Consensus Guidelines on Management","volume":"89","author":"Mollan","year":"2018","journal-title":"J Neurol Neurosurg  Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-020-01288-1","article-title":"A Systematic Review of Surgical Treatments of Idiopathic Intracranial Hypertension (IIH)","volume":"44","author":"Kalyvas","year":"2021","journal-title":"Neurosurg Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","article-title":"Revised Diagnostic Criteria for the Pseudotumor Cerebri Syndrome in Adults and Children","volume":"81","author":"Friedman","year":"2013","journal-title":"Neurology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000357503","article-title":"Idiopathic Intracranial Hypertension. A Systematic Analysis of Transverse Sinus Stenting","volume":"2","author":"Teleb","year":"2013","journal-title":"Interv Neurol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2575","article-title":"Transverse Sinus Stenting for Idiopathic Intracranial Hypertension: A Review of 52 Patients and of Model Predictions","volume":"32","author":"Ahmed","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1890","article-title":"Unilateral Transverse Sinus Stenting of Patients With Idiopathic Intracranial Hypertension","volume":"31","author":"Bussi\u00e8re","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002774","article-title":"The APOSTEL Recommendations for Reporting Quantitative Optical Coherence Tomography Studies","volume":"86","author":"Cruz-Herranz","year":"2016","journal-title":"Neurology"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034823","article-title":"The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment","volume":"7","author":"Tewarie","year":"2012","journal-title":"PLos One"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-020-00908-z","article-title":"Long-Term Kinetic Papilledema Improvement After Venous Sinus Stenting in Idiopathic Intracranial Hypertension","volume":"31","author":"Touz\u00e9","year":"2021","journal-title":"Clin Neuroradiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1007\/s10143-022-01742-2","article-title":"Neuro-Ophthalmological Evaluation Including Optical Coherence Tomography Surrounding Venous Sinus Stenting in Idiopathic Intracranial Hypertension With Papilledema: A Case Series","volume":"45","author":"Hendrix","year":"2022","journal-title":"Neurosurg Rev"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000426","article-title":"Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Results of a Prospective Trial","volume":"37","author":"Dinkin","year":"2017","journal-title":"J Neuro-Ophthalmol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e318238b9cb","article-title":"Role of the Macular Optical Coherence Tomography Scan in Neuro-Ophthalmology","volume":"31","author":"Kardon","year":"2011","journal-title":"J Neuro-Ophthalmol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1279","article-title":"Endovascular Stenting for Idiopathic Intracranial Hypertension With Venous Sinus Stenosis","volume":"9","author":"Liu","year":"2019","journal-title":"Brain Behav"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1159\/000146661","article-title":"Cerebral Venous Sinuses: Anatomical Variants or Thrombosis","volume":"133","author":"Zouaoui","year":"1988","journal-title":"Cells Tissues Organs"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.25.873","article-title":"Anatomical Study of the Torcular Herophili","volume":"25","author":"Ishizaka","year":"1985","journal-title":"Neurol Med Chirur"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000930302","article-title":"The Confluence of Dural Venous Sinuses","volume":"93","author":"Browning","year":"1953","journal-title":"Am J Anat"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014172","article-title":"Venous Sinus Stenting for Idiopathic Intracranial Hypertension: A Systematic Review and Meta-Analysis","volume":"11","author":"Nicholson","year":"2019","journal-title":"J neurointerv Surg"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3171\/2015.12.JNS152033","article-title":"Incidence and Predictors of Dural Venous Sinus Pressure Gradient in Idiopathic Intracranial Hypertension and non-Idiopathic Intracranial Hypertension Headache Patients: Results From 164 Cerebral Venograms","volume":"126","author":"Levitt","year":"2017","journal-title":"J Neurosurg"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-017-1783-5","article-title":"Endovascular Treatment of Idiopathic Intracranial Hypertension: Retrospective Analysis of Immediate and Long-Term Results in 51 Patients","volume":"59","author":"Aguilar-P\u00e9rez","year":"2017","journal-title":"Neuroradiology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/19714009211026923","article-title":"Efficacy of Dural Venous Sinus Stenting in Treating Idiopathic Intracranial Hypertension With Acute Vision Loss","volume":"35","author":"Zehri","year":"2022","journal-title":"Neuroradiol J"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016550","article-title":"Predicting the Need for Retreatment in Venous Sinus Stenting for Idiopathic Intracranial Hypertension","volume":"13","author":"Kahan","year":"2021","journal-title":"J neurointerv Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/neurintsurg-2020-016124","article-title":"Quality of Life, Need for Retreatment, and the Re-Equilibration Phenomenon After Venous Sinus Stenting for Idiopathic Intracranial Hypertension","volume":"13","author":"Garner","year":"2021","journal-title":"J neurointerv Surg"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2022.910524\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T03:59:12Z","timestamp":1656561552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2022.910524\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":29,"alternative-id":["10.3389\/fopht.2022.910524"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2022.910524","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]},"article-number":"910524"}}