{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:03Z","timestamp":1753891863047,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>We hereby describe a case of persistent cytomegalovirus (CMV) viremia and retinitis following allogeneic hematopoietic cell transplantation (HCT) that was successfully treated with infusion of CMV-specific cytotoxic T lymphocytes (CTL) despite previous treatment with Epstein Bar Virus (EBV) -specific CTL, which occurred 5 months earlier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observations<\/jats:title><jats:p>Following several anti- viral medication treatment trials that failed to eradicate the infectious process, the patient was treated with infusions of CMV-CTL from a biobank of cryopreserved virus-specific cells. Shortly after the first infusion, a remarkable response was noted. A few days after the second infusion, the retinitis resolved completely. No recurrence was noted at the one-year follow-up, and there was no evidence of GVHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and importance<\/jats:title><jats:p>The case is unique for two reasons: use of virus-specific CTL for an indication of CMV retinitis; and successive administration, in the same patient, of third-party virus-specific CTL to treat two different infections (Epstein-Barr virus and cytomegalovirus) on two separate occasions following hematopoietic cell transplantation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fopht.2023.1131674","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:24:11Z","timestamp":1688369051000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Cytomegalovirus-specific T-lymphocyte infusion for resistant cytomegalovirus retinitis"],"prefix":"10.3389","volume":"3","author":[{"given":"Tal","family":"Saban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Shargian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Eiger-Moscovitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Prockop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekatarina","family":"Doubrovina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Yeshurun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0993","article-title":"Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity","volume":"101","author":"Boeckh","year":"2003","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700801","article-title":"Screening for CMV-specific T cell proliferation to identify patients at risk of developing late onset CMV disease","volume":"19","author":"Krause","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1086\/517301","article-title":"Late cytomegalovirus disease in marrow transplantation is predicted by virus load in plasma","volume":"176","author":"Zaia","year":"1997","journal-title":"J Infect Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2217\/imt.15.70","article-title":"Therapeutic strategies for cytomegalovirus in allogeneic hematopoietic cell transplantation","volume":"7","author":"Nishihori","year":"2015","journal-title":"Immunotherapy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-371971","article-title":"Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation","volume":"119","author":"Doubrovina","year":"2012","journal-title":"Blood"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14634-X","article-title":"Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines","volume":"362","author":"Peggs","year":"2003","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510193331603","article-title":"Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor","volume":"333","author":"Walter","year":"1995","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.232","article-title":"Viral-specific T-cell transfer from HSCT donor for the treatment of viral infections or diseases after HSCT","volume":"53","author":"Qian","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-628982","article-title":"T Cells for viral infections after allogeneic hematopoietic stem cell transplant","volume":"127","author":"Bollard","year":"2016","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26535","article-title":"Adoptive therapy with cytomegalovirus-specific T cells for cytomegalovirus infection after haploidentical stem cell transplantation and factors affecting efficacy","volume":"97","author":"Pei","year":"2022","journal-title":"Am J Hematol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121127","article-title":"Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation","volume":"130","author":"Prockop","year":"2020","journal-title":"J Clin Invest"},{"key":"B12","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1182\/bloodadvances.2020002735","article-title":"Adoptive therapy with CMV-specific cytotoxic T lymphocytes depends on baseline CD4+ immunity to mediate durable responses","volume":"5","author":"Fabrizio","year":"2021","journal-title":"Blood Adv"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.10.004","article-title":"Virus specific T cells: broadening applicability","volume":"24","author":"Barrett","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20150101-14","article-title":"Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion","volume":"46","author":"Gupta","year":"2015","journal-title":"Opht Surg Lasers Imaging Retina"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00523.x","article-title":"A case of immune recovery vitritis induced by donor leukocyte infusion for the treatment of cytomegalovirus retinitis","volume":"75","author":"Kawakami","year":"2005","journal-title":"Eur J Haematol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1182\/bloodadvances.2019000121","article-title":"Adoptive T-cell therapy for pediatric cytomegalovirus-associated retinitis","volume":"3","author":"Seo","year":"2019","journal-title":"Blood Adv"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2023.1131674\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:24:14Z","timestamp":1688369054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2023.1131674\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":16,"alternative-id":["10.3389\/fopht.2023.1131674"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2023.1131674","relation":{},"ISSN":["2674-0826"],"issn-type":[{"type":"electronic","value":"2674-0826"}],"subject":[],"published":{"date-parts":[[2023,7,3]]},"article-number":"1131674"}}