{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:32:24Z","timestamp":1788273144048,"version":"build-2803163510"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/25650-8 , 2013\/06580-9, 2015\/17226-7 , 2018\/09448-8, 2018\/04709-8"],"award-info":[{"award-number":["2013\/25650-8 , 2013\/06580-9, 2015\/17226-7 , 2018\/09448-8, 2018\/04709-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Ocular toxoplasmosis (OT) is an intraocular inflammation caused by <jats:italic>Toxoplasma gondii<\/jats:italic> infection that affects the retina and choroid, giving rise to posterior uveitis. Genetic polymorphisms in cytokine genes may exert influence in the expression of these molecules and play a significant role in inflammatory responses and susceptibility to OT. The aim of this study was to evaluate the role of polymorphisms rs16944 (\u2013511 C\u00a0&amp;gt;\u00a0T) of the <jats:italic>interleukin (IL) 1\u03b2<\/jats:italic> gene and rs1800896 (\u20131082 G\u00a0&amp;gt;\u00a0A) of the <jats:italic>IL10<\/jats:italic> gene on OT in Brazilian individuals with a serologic diagnosis of <jats:italic>T. gondii<\/jats:italic> and after conducting fundoscopic exams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with a positive serology were classified into two distinct groups according to the presence (G1; <jats:italic>n<\/jats:italic>\u00a0=\u00a0110) or absence (G2; <jats:italic>n<\/jats:italic>\u00a0=\u00a0104) of OT. The control group (G3) consisted of individuals without the infection (<jats:italic>n\u00a0<\/jats:italic>=\u00a0108).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was observed that the C\/C genotype of the <jats:italic>IL1\u03b2<\/jats:italic> gene polymorphism was a protective factor for OT (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, OR\u00a0=\u00a00.28, 95% CI 0.08\u20130.78 for G1 vs. G2; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03; OR\u00a0=\u00a00.29, 95% CI 0.09\u20130.82 for G1 vs. G3), according to the recessive inheritance model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The -511C.T polymorphisms of the <jats:italic>IL1\u03b2<\/jats:italic> gene seems to play an important role in the pathogenesis of OT in Brazilian individuals.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fopht.2023.1183167","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T04:55:07Z","timestamp":1688100907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of interleukin 1\u03b2 and interleukin 10 variants on ocular toxoplasmosis in Brazilian individuals"],"prefix":"10.3389","volume":"3","author":[{"given":"Warlen Miiller Rocha","family":"Araujo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane Maria","family":"Ayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Previato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Geraldo Magela","family":"de Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Batista","family":"Frederico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens Camargo","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Gild\u00e1sio Castello","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L\u00facia","family":"Pereira-Chioccola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"de Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinara C\u00e1ssia","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.preteyeres.2013.12.005","article-title":"Ocular toxoplasmosis past, present and new aspects of an old disease","volume":"39","author":"Maenz","year":"2014","journal-title":"Prog Retin. 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