{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:20Z","timestamp":1753891880505,"version":"3.41.2"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe a unique presentation of optic neuritis associated with positive HLA-B35.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observations<\/jats:title><jats:p>A woman presented with unilateral retro-orbital pain, mildly decreased vision, and optic disc edema with new-onset aphthous ulcers. Color vision was preserved, and no visual field deficits were noted. Diagnostic imaging demonstrated retrobulbar optic nerve enhancement, with genetic testing revealing HLA-B35 positivity. Treatment with high-dose oral steroids for 3 days resolved all symptoms, and the patient remained stable for at least 2 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and importance<\/jats:title><jats:p>In addition to rheumatic conditions and oral lesions, HLA-B35 can be linked to optic neuritis. This relationship highlights the need to further explore genetic risk factors associated with optic neuritis and the potential need for human leukocyte antigen (HLA) testing in unusual cases of optic neuritis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fopht.2024.1483937","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:24:07Z","timestamp":1732170247000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: HLA-B35-associated optic neuritis"],"prefix":"10.3389","volume":"4","author":[{"given":"Florian H.","family":"Guillot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/sji.2015.82.issue-4","article-title":"Clinical role of human leukocyte antigen in health and disease","volume":"82","author":"Mosaad","year":"2015","journal-title":"Scandinavian J Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2005.00548.x","article-title":"HLA and eye disease: a synopsis","volume":"32","author":"Goverdhan","year":"2005","journal-title":"Int J Immunogenetics"},{"key":"B3","article-title":"Chromosome 19 single-locus and multilocus haplotype associations with multiple sclerosis. 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Association with HLA-B35 and Cw4 antigens","volume":"13","author":"Ferraccioli","year":"1986","journal-title":"J Rheumatol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-04999-4","article-title":"The occurrence of sacroiliitis in HLA-B*35-positive patients with undifferentiated spondyloarthritis. A cross sectional MRI study","volume":"39","author":"\u0160o\u0161o","year":"2020","journal-title":"Clin Rheumatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64574-9","article-title":"Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis","volume":"157","author":"Butterfield","year":"2000","journal-title":"Am J Pathol"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2024.1483937\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:24:09Z","timestamp":1732170249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2024.1483937\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":13,"alternative-id":["10.3389\/fopht.2024.1483937"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2024.1483937","relation":{},"ISSN":["2674-0826"],"issn-type":[{"type":"electronic","value":"2674-0826"}],"subject":[],"published":{"date-parts":[[2024,11,21]]},"article-number":"1483937"}}