{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:23Z","timestamp":1753891823802,"version":"3.41.2"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>We describe an unusual case of a rapidly progressive pilomatricoma along the left brow, which was initially misdiagnosed and treated as preseptal cellulitis. Although rare, pilomatricomas and other adnexal tumors should be considered in the differential diagnosis of a growing mass near the brow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 29-year-old male presented to the emergency department with a progressively enlarging left brow lesion, initially noted 3 weeks prior. Exam revealed an erythematous left subbrow mass that measured 2.5 x 2 cm, with resultant mechanical ptosis. The lesion was initially misdiagnosed and treated as preseptal cellulitis, with concern for abscess. The patient ultimately underwent excisional biopsy of the lesion and pathology revealed pilomatricoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pilomatricoma has similarities to more common skin lesions. Lack of pain or tenderness are important clues against an infectious or inflammatory etiology. Complete surgical excision is therapeutic and allows for diagnostic confirmation. Histopathology is required to rule out pilomatrix carcinoma, a malignant variant.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fopht.2025.1503693","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:56:34Z","timestamp":1737615394000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis"],"prefix":"10.3389","volume":"5","author":[{"given":"Rahul","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane Z.","family":"Spadaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Kahana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2020.00528","article-title":"Clinical analysis and review of literature on pilomatrixoma in pediatric patients","volume":"21","author":"Hu","year":"2020","journal-title":"Arch Craniofacial Surg"},{"key":"B2","article-title":"Clinicopathological study of pilomatricoma","volume":"22","author":"Darwish","year":"2001","journal-title":"Saudi Med J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13046","article-title":"Pilomatrix carcinoma: 12-year experience and review of the literature","volume":"45","author":"Jones","year":"2018","journal-title":"J Cutan Pathol"},{"key":"B4","first-page":"ic1","article-title":"Eyebrow lesion: an unusual suspect","volume":"15","author":"Marano","year":"2015","journal-title":"Eplasty"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.82134","article-title":"Malherbe\u2019s calcifying epithelioma (Pilomatrixoma): an uncommon periocular tumor","volume":"3","author":"Ali","year":"2011","journal-title":"Int J Trichol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.12.1481","article-title":"Head and neck pilomatrixoma in children","volume":"127","author":"Danielson-Cohen","year":"2001","journal-title":"Arch Otolaryngol Neck Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.74566","article-title":"Pilomatricoma as a diagnostic pitfall in clinical practice: report of two cases and review of literature","volume":"55","author":"Pant","year":"2010","journal-title":"Indian J Dermatol"},{"key":"B8","article-title":"Not your average skin cancer: A rare case of pilomatrix carcinoma","volume":"13","author":"White","year":"2020","journal-title":"J Clin Aesthetic Dermatol"},{"key":"B9","article-title":"Pilomatricoma: an unusual dermatologic neoplasm","volume":"71","author":"DeRosa","year":"2012","journal-title":"Hawaii J Med Public Health J Asia Pac Med Public Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4103\/0019-5154.174035","article-title":"Pilomatricoma mimicking ruptured epidermal cyst in a middle aged woman","volume":"61","author":"Sarkar","year":"2016","journal-title":"Indian J Dermatol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001118","article-title":"Pilomatrixoma: A comprehensive review of the literature","volume":"40","author":"Jones","year":"2018","journal-title":"Am J Dermatopathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/7747","article-title":"A common human skin tumour is caused by activating mutations in beta-catenin","volume":"21","author":"Chan","year":"1999","journal-title":"Nat Genet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00887.x","article-title":"Pilomatrix carcinoma arising from pilomatricoma after 10-year senescent period: Immunohistochemical analysis","volume":"37","author":"Nishioka","year":"2010","journal-title":"J Dermatol"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2025.1503693\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:56:37Z","timestamp":1737615397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2025.1503693\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":13,"alternative-id":["10.3389\/fopht.2025.1503693"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2025.1503693","relation":{},"ISSN":["2674-0826"],"issn-type":[{"type":"electronic","value":"2674-0826"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"article-number":"1503693"}}