{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:41:17Z","timestamp":1788352877057,"version":"build-2803163510"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Advancements in anterior segment imaging have significantly improved the precision of corneal diagnostics, aiding ocular conditions management. The study evaluated the agreement between two Scheimpflug devices\u2014Pentacam and Remidio Visionix 650 (VX650)\u2014in assessing corneal and anterior chamber parameters in patients with and without corneal abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This prospective study at a tertiary eye care hospital measured pachymetry values (central corneal thickness, thinnest point), front corneal surface parameters (keratometry, curvature, astigmatism), back corneal surface parameters (elevation, curvature) and anterior chamber parameters (depth, volume, angle). Bland-Altman analysis assessed agreement between the devices, and the Intraclass Correlation Coefficient (ICC) evaluated VX650\u2019s repeatability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 202 patients (mean age was 25 \u00b1 4.33 years), 141 eyes were classified as normal and 61 as abnormal (41 keratoconus, 17 post-LASIK, 3 post-ICL). Bland-Altman analysis showed good agreement between Pentacam and VX650 for anterior segment parameters. The VX650 measured marginally thicker corneal thickness (mean difference of central corneal thickness (CCT) of -4.0 \u00b1 6.3 \u00b5m). Statistically significant differences in apical corneal thickness were noted for post-refractive surgery patients. K1 and K2 values showed significant variations in keratoconus but were not clinically significant. Anterior chamber depth was similar between devices, though volume differences were observed post-surgery. ICC indicated good to excellent repeatability (above 0.75) for most parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Remidio Visionix VX650 showed good agreement with Pentacam for key anterior segment measurements, confirming its reliability for corneal diagnostics. Additionally, its multifunctional capabilities offer potential for streamlining workflows, especially in clinics seeking efficient, comprehensive eye assessments.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fopht.2025.1516423","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:48:58Z","timestamp":1739947738000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["A prospective comparison of Scheimpflug-based anterior segment imaging systems in normal and abnormal corneas: Oculus Pentacam vs. Remidio Visionix VX650"],"prefix":"10.3389","volume":"5","author":[{"given":"Sonam","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpa","family":"Negiloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul Chawla","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjitha","family":"K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"N","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Parthasarathy Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Damani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonraj","family":"Ballae Ganesh Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Duggal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7246730","article-title":"Evaluation of intraocular lens tilt and decentration in congenital ectopia lentis by the pentacam scheimpflug system","volume":"2022","author":"Ye","year":"2022","journal-title":"J Ophthalmol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6128832","article-title":"Characteristics of anterior segment in congenital ectopia lentis: an SS-OCT study","volume":"2022","author":"Qi","year":"2022","journal-title":"J Ophthalmol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7339306","article-title":"Simultaneous corneal topography and epithelial thickness mapping from a single measurement using optical coherence tomography","volume":"2022","author":"Sikorski","year":"2022","journal-title":"J Ophthalmol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.3390\/diagnostics11081466","article-title":"Current developments in corneal topography and tomography","volume":"11","author":"Kanclerz","year":"2021","journal-title":"Diagnostics"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S392665","article-title":"Keratoconus diagnosis and treatment: recent advances and future directions","volume":"17","author":"Bui","year":"2023","journal-title":"Clin Ophthalmol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.65.e74326","article-title":"Custom anterior segment optical coherence tomography indices for detection of corneal ectasia","volume":"65","author":"Atanassov","year":"2023","journal-title":"Folia Med (Plovdiv)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.61838\/kman.najm.1.2.3","article-title":"Evolving visions: A comprehensive review of contemporary and emerging technologies in anterior segment imaging","volume":"1","author":"Bhat","year":"2023","journal-title":"N Asian J Med"},{"key":"B8","article-title":"Optical coherence tomography imaging in keratoconus","volume":"23","author":"Sun","year":"2023","journal-title":"Int Eye Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14715","article-title":"Tomographic and aberrometric assessment of first-time diagnosed paediatric keratoconus based on age ranges: a multicentre study","volume":"99","author":"Rocha-de-Lossada","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20200629-01","article-title":"Bilateral keratoconus progression: immediate versus delayed sequential bilateral corneal cross-linking","volume":"36","author":"Pagano","year":"2020","journal-title":"J Refractive Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.4103\/ijo.IJO_2111_20","article-title":"Simplifying and understanding various topographic indices for keratoconus using Scheimpflug based topographers","volume":"68","author":"Doctor","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2016.01.009","article-title":"Pentacam top indices for diagnosing subclinical and definite keratoconus","volume":"28","author":"Hashemi","year":"2016","journal-title":"J Curr Ophthalmol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_729_16","article-title":"Repeatability and agreement of five imaging systems for measuring anterior segment parameters in healthy eyes","volume":"65","author":"Kumar","year":"2017","journal-title":"Indian J Ophthalmol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"315281","DOI":"10.1155\/2015\/315281","article-title":"Comparison of two different Scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas","volume":"2015","author":"Finis","year":"2015","journal-title":"J Ophthalmol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000119","article-title":"Comparison of central corneal thickness, thinnest corneal thickness, anterior chamber depth, and simulated keratometry using Galilei, Pentacam, and Sirius devices","volume":"33","author":"Anayol","year":"2014","journal-title":"Cornea"},{"key":"B17","doi-asserted-by":"publisher","first-page":"16956","DOI":"10.1038\/s41598-023-44133-3","article-title":"Comparison of corneal measurements using two different Scheimpflug analyzers in Sirius and Pentacam devices","volume":"13","author":"Abdi","year":"2023","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4103\/jovr.jovr_104_16","article-title":"Comparison between two scheimpflug anterior segment analyzers","volume":"12","author":"Baradaran-Rafii","year":"2017","journal-title":"J Ophthalmic Vis Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2019.08.12","article-title":"Comparison of corneal curvature parameters obtained from two different instruments-Pentacam and VX120","volume":"12","author":"Zhang","year":"2019","journal-title":"Int J Ophthalmol"}],"container-title":["Frontiers in Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2025.1516423\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:49:00Z","timestamp":1739947740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fopht.2025.1516423\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":19,"alternative-id":["10.3389\/fopht.2025.1516423"],"URL":"https:\/\/doi.org\/10.3389\/fopht.2025.1516423","relation":{},"ISSN":["2674-0826"],"issn-type":[{"value":"2674-0826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"article-number":"1516423"}}