{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:14:55Z","timestamp":1758586495058,"version":"3.44.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Ophthalmol."],"abstract":"<jats:p>Myelin oligodendrocyte glycoprotein-associated optic neuritis (MOG-ON) is a sight-threatening demyelinating disorder that can present with various ocular manifestations. Here, we describe a unique case of bilateral MOG-ON with unilateral retinal hemorrhages and Roth spots. We present the case of a 48-year-old man with acute-onset painful, severe vision loss in both eyes. Initial fundoscopic examination revealed bilateral optic nerve edema with unilateral retinal hemorrhages and Roth spots. Imaging was notable for perineural enhancement along both optic nerves. Serological testing revealed elevated MOG antibodies. The patient was treated with high-dose intravenous steroids followed by plasmapheresis, which resulted in substantial clinical improvement. We conducted a literature review of all available studies published before March 30, 2025, using PubMed, including the keywords \u201cmyelin oligodendrocyte glycoprotein-associated optic neuritis,\u201d \u201cmyelin oligodendrocyte glycoprotein,\u201d \u201coptic neuritis,\u201d \u201cRoth spots,\u201d and \u201cretinal hemorrhage.\u201d We found that this is the first reported case in a male patient\u2014and only the third reported case overall\u2014of retinal hemorrhages and Roth spots occurring in the context of MOG-ON. While retinal hemorrhage and Roth spots have not historically been associated with MOG-ON, recognizing the spectrum of fundoscopic findings is crucial for the early diagnosis and management of this potentially sight-threatening disease.<\/jats:p>","DOI":"10.3389\/fopht.2025.1620614","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:12:28Z","timestamp":1758514348000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Fundus findings in myelin oligodendrocyte glycoprotein-associated optic neuritis"],"prefix":"10.3389","volume":"5","author":[{"given":"John R.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia W.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Elitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory P.","family":"Van Stavern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.885218","article-title":"Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of clinical and MRI features, diagnosis, and management","volume":"13","author":"Sechi","year":"2022","journal-title":"Front Neurol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000540776","article-title":"A rare presentation of myelin oligodendrocyte glycoprotein-associated optic neuritis with venous stasis retinopathy and premacular hemorrhage: A case report","volume":"15","author":"Srimanan","year":"2024","journal-title":"Case Rep 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